Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex III Entry 313 24/11/2020

HEMA

2-Hydroxyethyl Methacrylate

HEMA is listed in Annex III and may only be used under the conditions shown in this record.

Search similar Back to annex Compare
Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 313

Chemical identity and properties

PubChem 2D chemical structure for CAS 868-77-9
CAS 868-77-9PubChem CID 13360

2-Hydroxyethyl Methacrylate

2-hydroxyethyl methacrylate is an enoate ester that is the monomethacryloyl derivative of ethylene glycol. It has a role as an allergen and a polymerisation monomer. It is functionally related to a methacrylic acid and an ethylene glycol. — ChEBI

IUPAC name
2-hydroxyethyl 2-methylprop-2-enoate
Molecular formula
C6H10O3
Molecular weight
130.14 g/mol
Exact mass
130.062994177 Da
XLogP3
0.5
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Glycol methacrylateHydroxyethyl methacrylateEthylene glycol methacrylateGlycol monomethacrylate2-(Methacryloyloxy)ethanol2-HydroxyethylmethacrylateMhoromerMonomer MG-1
16 more reported names
Ethylene glycol monomethacrylate2-Propenoic acid, 2-methyl-, 2-hydroxyethyl esterbeta-Hydroxyethyl methacrylateEthylene glycol, monomethacrylateMonomethacrylic ether of ethylene glycol6E1I4IV47VCHEBI:34288NSC-241802-HEMARefChem:6745212-782-2927-388-2HEMAMethacrylic acid, 2-hydroxyethyl esterNSC 24180(hydroxyethyl)methacrylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Product type

Nail products

Other restrictions

Professional use only

Warnings

For professional use only.

Can cause an allergic reaction.

INCI glossary name

HEMA

Chemical name

2-Hydroxyethyl Methacrylate

Chemical / IUPAC name

2-Hydroxyethyl Methacrylate* *From 3 June 2021 products containing that substance and not complying with those conditions shall not be placed on the Union market. From 3 September 2021 products containing that substance and not complying with those conditions shall not be made available on the Union market

Regulatory information

Regulation

(EU) 2020/1682

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
868-77-9
EC
212-782-2
Annex
III
Entry number
313

Inventory links for HEMA

Inventory Identified ingredient
Ref 56349

HEMA

CAS: 868-77-9
EC: 212-782-2

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 185
Shared product type

TOLUENE

CAS: 108-88-3
EC: 203-625-9
Annex III 312
Nearby record in the same annex

FURFURAL

CAS: 98-01-1
EC: 202-627-7
Annex III 310
Nearby record in the same annex

CLIMBAZOLE

CAS: 38083-17-9;
EC: 253-775-4;
Annex III 307
Nearby record in the same annex

HYDROLYZED WHEAT PROTEIN

CAS: 94350-06-8 / 222400-28-4 / 70084-87-6 / 100209- 50-5
EC: 305-225-0/ -/ 309-358-5

What Annex III means for HEMA

HEMA is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 11 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: Nail products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HEMA is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 868-77-9 is the unique numerical identifier assigned to HEMA by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex III record HEMA

This page summarizes one Annex III record for HEMA from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HEMA, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect HEMA and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare HEMA side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex III and compare regulatory conditions across substances in this annex.

Open Annex III