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Annex II Entry 1313 21/10/2010

Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

Toluene-3,4-diamine and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1313

Chemical identity and properties

PubChem 2D chemical structure for CAS 496-72-0
CAS 496-72-0PubChem CID 10332

3,4-Diaminotoluene

3,4-diaminotoluene appears as a colorless to brownish purple crystalline solid. Toxic by ingestion and inhalation and an irritant to skin and eyes. Soluble in water, alcohol and ether. Decomposes to emit toxic oxides of nitrogen when heated to high temperature. Used in making dyes. — CAMEO Chemicals

IUPAC name
4-methylbenzene-1,2-diamine
Molecular formula
C7H10N2
Molecular weight
122.17 g/mol
Exact mass
122.084398327 Da
XLogP3
0.6
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

4-Methyl-o-phenylenediamine1,2-Benzenediamine, 4-methyl-Toluene-3,4-diamine4-Methyl-1,2-benzenediamine4-Methyl-1,2-phenylenediamine3,4-Tolylenediamine1,2-Diamino-4-methylbenzene4-Methyl-1,2-diaminobenzene
16 more reported names
3,4-Toluylenediamine3,4-Diamino-1-methylbenzeneNSC 1495CCRIS 4611HSDB 6070EINECS 207-826-2OE7HJ54P5CBRN 05079653,4-DIAMINOTOLUENE [HSDB]NSC-1495DIAMINOTOLUENE, 3,4-4-13-00-00260 (Beilstein Handbook Reference)3,4ToluenediamineToluene3,4diamine3,4Tolylenediamine3,4Toluylenediamine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Identified ingredients

Key data

CAS
496-72-0
EC
207-826-2
Annex
II
Entry number
1313

Inventory links for Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

Toluene-3,4-diamine and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Toluene-3,4-diamine and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 496-72-0 is the unique numerical identifier assigned to Toluene-3,4-diamine and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for Toluene-3,4-diamine and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Toluene-3,4-diamine and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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