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Annex II Entry 1310 21/10/2010

4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products

4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1310

Chemical identity and properties

PubChem 2D chemical structure for CAS 148-71-0
CAS 148-71-0PubChem CID 67364

2-Amino-5-(diethylamino)toluene

IUPAC name
4-N,4-N-diethyl-2-methylbenzene-1,4-diamine
Molecular formula
C11H18N2
Molecular weight
178.27 g/mol
Exact mass
178.146998583 Da
XLogP3
2.1
Topological polar surface area
29.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

A640ZQ81DV3-Methyl-N,N-diethyl-p-phenylenediamineCD-2 color developerRefChem:515781N(4),N(4)-diethyl-2-methyl-1,4-benzenediamine1,4-Benzenediamine, N4,N4-diethyl-2-methyl-N1,N1-Diethyl-3-methylbenzene-1,4-diamine4-Diethylamino-o-toluidine
16 more reported names
4-(Diethylamino)-2-methylanilineN-4,N-4-Diethyl-2-methyl-1,4-benzenediamineN4,N4-diethyl-2-methyl-1,4-Benzenediamine3-methyl-4-amino-n,n-diethylaniline4-Amino-3-methyl-N,N-diethylanilineToluene-2,5-diamine, N5,N5-diethyl-N4,N4-Diethyl-2-methyl-p-phenylenediamineN~4~,N~4~-diethyl-2-methylbenzene-1,4-diamine(4-amino-3-methylphenyl)diethylamineUNII-A640ZQ81DVCD-2EINECS 205-722-1N4,N4-diethyl-2-methyl-benzene-1,4-diamineCBDivE_0029482-Amino-5-diethylaminotoluene2-methyl-4-diethylaminoaniline
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 2051-79-8
CAS 2051-79-8CAS 24828-38-4PubChem CID 108623

N,N-Diethyltoluene-2,5-diamine hydrochloride

IUPAC name
4-N,4-N-diethyl-2-methylbenzene-1,4-diamine;hydrochloride
Molecular formula
C11H19ClN2
Molecular weight
214.73 g/mol
Exact mass
214.1236763 Da
Topological polar surface area
29.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
2
Defined stereocentres
0

Also known as

2-Amino-5-(diethylamino)toluene Monohydrochloride4-Diethylamino-o-toluidine HCl1,4-Benzenediamine, N4,N4-diethyl-2-methyl-, monohydrochloride1,4-Benzenediamine, N4,N4-diethyl-2-methyl-, hydrochloride (1:1)PPD 239MIH70E0IEINECS 246-484-94-Diethylamino-o-toluidine hydrochloride
16 more reported names
N,N-DIETHYLTOLUENE-2,5-DIAMINE HCL4-AMINO-N,N-DIETHYL-M-TOLUIDINE HYDROCHLORIDE3-METHYL-4-AMINO-N,N-DIETHYLANILINE HYDROCHLORIDE3-METHYL-4-AMINO-N,N-DIETHYLANILINE MONOHYDROCHLORIDEN5, N5-DIETHYLTOLUENE-2,5-DIAMINE MONOHYDROCHLORIDEN',N'-DIETHYL-2-METHYL-1,4-PHENYLENEDIAMINE MONOHYDROCHLORIDERefChem:822343N,N-DIETHYLTOLUENE-2,5-DIAMINE HCL [INCI]1,4-Benzenediamine, N4,N4-diethyl-2-methyl-, hydrochloride246-484-9N5,N5-Diethyltoluene-2,5-diamine monohydrochloride4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride2-amino-5-(diethylamino)toluene hydrochloride4-N,N-Diethyl-2-methyl-p-phenylenediamine monohydrochlorideN4,N4-diethyl-2-methyl-1,4-Benzenediamine hydrochlorideN1,N1-Diethyl-3-methylbenzene-1,4-diamine xhydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
148-71-0 / 24828-38-4 / 2051-79-8
EC
205-722-1 / 246-484-9 / 218-130-3
Annex
II
Entry number
1310

Inventory links for 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products

4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 148-71-0 / 24828-38-4 / 2051-79-8 is the unique numerical identifier assigned to 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Diethylamino-o-toluidine and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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