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Annex II Entry 1319 08/12/2010

2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products

2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1319

Chemical identity and properties

PubChem 2D chemical structure for CAS 18266-52-9
CAS 18266-52-9PubChem CID 5360562

1,4-Benzenediamine, 2-nitro-, hydrochloride (1:2)

IUPAC name
2-nitrobenzene-1,4-diamine;dihydrochloride
Molecular formula
C6H9Cl2N3O2
Molecular weight
226.06 g/mol
Exact mass
225.0071819 Da
Topological polar surface area
97.9 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Covalent units
3
Defined stereocentres
0

Also known as

HSDB 6254UNII-FS1IP6390X2-nitro-p-phenylenediamine dihydrochlorideEINECS 242-144-92-NITRO-1,4-BENZENEDIAMINE DIHYDROCHLORIDE2-NITRO-1,4-BENZENEDIAMINE DIHYDROCHLORIDE [HSDB]RefChem:730482Nitrobenzene1,4diamine dihydrochloride
10 more reported names
pPhenylenediamine, 2nitro, dihydrochloride1,4Benzenediamine, 2nitro, dihydrochloride2-NITRO-P-PHENYLENEDIAMINE DIHYDROCHLORIDE [INCI]242-144-9FS1IP6390Xp-Phenylenediamine, 2-nitro-, dihydrochloride1,4-Benzenediamine, 2-nitro-, dihydrochloride2-Nitrobenzene-1,4-diamine dihydrochlorideVTJQZXFQQIDLRW-UHFFFAOYSA-N2-Nitrobenzene-1,4-diamine--hydrogen chloride (1/2)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 5307-14-2
CAS 5307-14-2PubChem CID 4338370

2-Nitro-4-phenylenediamine

2-nitro-p-phenylenediamine is a primary amino compound that is p-phenylenediamine in which one of the hydrogens attached to the benzene ring is replaced by a nitro group. It is a cosmetic hair dye intermediate that is used in permanent hair colouring products (diluted 1:1 with an oxidising agent prior to application). It is a C-nitro compound and a primary amino compound. It is functionally related to a 1,4-phenylenediamine. — ChEBI

IUPAC name
2-nitrobenzene-1,4-diamine
Molecular formula
C6H7N3O2
Molecular weight
153.14 g/mol
Exact mass
153.053826475 Da
XLogP3
0.5
Topological polar surface area
97.9 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:887002-Nitro-1,4-phenylenediamine2-NITRO-P-PHENYLENEDIAMINE1,4-Diamino-2-nitrobenzene1,4-Benzenediamine, 2-nitro-2,5-Diaminonitrobenzene2-Nitro-1,4-benzenediamineo-Nitro-p-phenylenediamine
16 more reported names
Durafur BrownFouramine 2RUrsol Brown RRZoba Brown RR2-NPPDDurafur Brown 2R4-Amino-2-nitroanilineFourrine 36Nitro-p-phenylenediamine2-Nitro-1,4-diaminobenzeneFourrine Brown 2ROxidation base 22Dye GS2-N-p-PDA2-Nitro-4-aminoanilinep-Phenylenediamine, 2-nitro-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 68239-83-8
CAS 68239-83-8PubChem CID 5361845

1,4-Benzenediamine, 2-nitro-, sulfate (1:1)

IUPAC name
2-nitrobenzene-1,4-diamine;sulfuric acid
Molecular formula
C6H9N3O6S
Molecular weight
251.22 g/mol
Exact mass
251.02120619 Da
Topological polar surface area
181.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
8
Covalent units
2
Defined stereocentres
0

Also known as

2-NITRO-1,4-BENZENEDIAMINE SULFATEHSDB 62552-nitro-p-phenylenediamine sulfateUNII-OE78404L3DRODOL BROWN 2RS2-Nitro-p-phenylenediamine, sulfateEINECS 269-477-2P-PHENYLENEDIAMINE, NITRO-, SULFATE
13 more reported names
NITRO-1,4-BENZENEDIAMINE SULFATE (1:1)2-NITRO-1,4-BENZENEDIAMINE SULFATE [HSDB]RefChem:730492Nitropphenylenediamine, sulfate2Nitrobenzene1,4diammonium sulphate1,4Benzenediamine, 2nitro, sulfate (1:1)2-NITRO-P-PHENYLENEDIAMINE SULFATE [INCI]269-477-22-Nitrobenzene-1,4-diamine sulfate2-Nitrobenzene-1,4-diammonium sulphateXRALJHVEDJNLBL-UHFFFAOYSA-N2-Nitrobenzene-1,4-diaminesulfateSulfuric acid--2-nitrobenzene-1,4-diamine (1/1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Identified ingredients

Key data

CAS
5307-14-2 / 18266-52-9 / 68239-83-8
EC
226-164-5 / 242-144-9 / 269-477-2
Annex
II
Entry number
1319

Inventory links for 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products

2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 5307-14-2 / 18266-52-9 / 68239-83-8 is the unique numerical identifier assigned to 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2-Nitro-p-phenylenediamine and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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