5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
5-Amino-2,6-dimethoxy-3-hydroxypyridine
- IUPAC name
- 5-amino-2,6-dimethoxypyridin-3-ol
- Molecular formula
- C7H10N2O3
- Molecular weight
- 170.17 g/mol
- Exact mass
- 170.06914219 Da
- XLogP3
- 0.4
- Topological polar surface area
- 77.6 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID00146396
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
Regulatory information
SCCS opinions
Identified ingredients
Key data
Inventory links for 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
Related records for 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products
N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow …
N,N-Dimethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products
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1,4-Dihydroxy-5,8-bis[(2-hydroxyethyl)amino]anthraquinone (Disperse Blue 7) and its salts, when use…
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What Annex II means for 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products
This page summarizes one Annex II record for 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.
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