What does the restriction note for TOLUENE-3,4-DIAMINE mean?

The restriction field for TOLUENE-3,4-DIAMINE reads: II/1313. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 496-72-0?

CAS 496-72-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TOLUENE-3,4-DIAMINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3863715/10/2010

TOLUENE-3,4-DIAMINE

4-methyl-o-phenylenediamine (CI 76042)

TOLUENE-3,4-DIAMINE is linked to 1 EU annex record on this page. Inventory note: II/1313.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 496-72-0

CAS 496-72-0PubChem CID 10332

3,4-Diaminotoluene

3,4-diaminotoluene appears as a colorless to brownish purple crystalline solid. Toxic by ingestion and inhalation and an irritant to skin and eyes. Soluble in water, alcohol and ether. Decomposes to emit toxic oxides of nitrogen when heated to high temperature. Used in making dyes. — CAMEO Chemicals

IUPAC name: 4-methylbenzene-1,2-diamine

Molecular formula: C7H10N2
Molecular weight: 122.17 g/mol
Exact mass: 122.084398327 Da
XLogP3: 0.6
Topological polar surface area: 52.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

4-Methyl-o-phenylenediamine1,2-Benzenediamine, 4-methyl-Toluene-3,4-diamine4-Methyl-1,2-benzenediamine4-Methyl-1,2-phenylenediamine3,4-Tolylenediamine1,2-Diamino-4-methylbenzene4-Methyl-1,2-diaminobenzene

16 more reported names

3,4-Toluylenediamine3,4-Diamino-1-methylbenzeneNSC 1495CCRIS 4611HSDB 6070EINECS 207-826-2OE7HJ54P5CBRN 05079653,4-DIAMINOTOLUENE [HSDB]NSC-1495DIAMINOTOLUENE, 3,4-4-13-00-00260 (Beilstein Handbook Reference)3,4ToluenediamineToluene3,4diamine3,4Tolylenediamine3,4Toluylenediamine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1319452
EPA DTXSID:DTXSID9024930
PubMed:22299643
PubMed:21781634
PubMed:21747866
PubMed:21583121
PubMed:21582885
PubMed:21578934
PubMed:21577489
PubMed:21522430
PubMed:21252056
PubMed:21202650
PubMed:20448268
PubMed:20032816

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TOLUENE-3,4-DIAMINE

INCI name

TOLUENE-3,4-DIAMINE

Description

4-methyl-o-phenylenediamine (CI 76042)

Record provenance

Inventory reference: 38637
Imported identity: TOLUENE-3,4-DIAMINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TOLUENE-3,4-DIAMINE

Annex II Restriction reference

Entry 1313

Toluene-3,4-diamine and its salts, when used as a substance in hair dye products

CAS: 496-72-0

EC: 207-826-2

Key data

CAS

496-72-0

207-826-2

Restriction

II/1313

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28960 · TOLUENE-3,4-DIAMINE

Ingredients with overlapping formulation functions

THYMOLDENATURANT, FRAGRANCE, HAIR DYEING

TOLUENE-2,5-DIAMINEHAIR DYEING

TOLUENE-2,5-DIAMINE SULFATEHAIR DYEING

TOLUENE-2,6-DIAMINEHAIR DYEING

ULTRAMARINESHAIR DYEING

VITEX NEGUNDO FLOWER/LEAF/SEED OILANTI-SEBUM, ANTIOXIDANT, HAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TOLUENE-3,4-DIAMINE appears in the CosIng inventory

The CosIng inventory lists TOLUENE-3,4-DIAMINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TOLUENE-3,4-DIAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TOLUENE-3,4-DIAMINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for TOLUENE-3,4-DIAMINE reads: "II/1313". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, TOLUENE-3,4-DIAMINE carries the following function designation(s):

HAIR DYEING

CAS 496-72-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TOLUENE-3,4-DIAMINE

This page combines the CosIng inventory entry for TOLUENE-3,4-DIAMINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research TOLUENE-3,4-DIAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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