2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
2,4-Diamino-5-methylphenoxyethanol hydrochloride
- IUPAC name
- 2-(2,4-diamino-5-methylphenoxy)ethanol;dihydrochloride
- Molecular formula
- C9H16Cl2N2O2
- Molecular weight
- 255.14 g/mol
- Exact mass
- 254.0588831 Da
- Topological polar surface area
- 81.5 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
3 more reported names
External database identifiers
- EPA DTXSID:DTXSID90150543
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
1-(2,4-Diamino-5-methylphenoxy)ethan-1-ol
- IUPAC name
- 1-(2,4-diamino-5-methylphenoxy)ethanol
- Molecular formula
- C9H14N2O2
- Molecular weight
- 182.22 g/mol
- Exact mass
- 182.105527694 Da
- XLogP3
- 0.7
- Topological polar surface area
- 81.5 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID30621727
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
Regulatory information
SCCS opinions
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
- Opinion concerning Hair Dyes without File submitted
- Opinion on Personal Use of Hair Dyes and Cancer Risk
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
- Assessment Strategies for Hair Dyes
- Opinion on 2,4-Diamino-5-methylphenoxyethanol HCl
Identified ingredients
Key data
Inventory links for 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
Related records for 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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What Annex II means for 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products
This page summarizes one Annex II record for 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 2,4-Diamino-5-methylphenoxyethanol and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.
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