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Annex II Entry 1311 21/10/2010

N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products

N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1311

Chemical identity and properties

PubChem 2D chemical structure for CAS 6065-27-6
CAS 6065-27-6CAS 6283-63-2PubChem CID 80166

N,N-Diethyl-p-phenylenediamine sulfate

IUPAC name
4-N,4-N-diethylbenzene-1,4-diamine;sulfuric acid
Molecular formula
C10H18N2O4S
Molecular weight
262.33 g/mol
Exact mass
262.09872823 Da
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

6283-63-2Diethyl-p-phenylenediamine sulfateN,N-Diethyl-1,4-phenylenediamine sulfateN,N-Diethyl-p-phenylenediamine sulfate salt1,4-Benzenediamine, N,N-diethyl-, sulfate (1:1)NSC 7653p-Amino-N,N-diethylaniline sulfateEINECS 228-500-6
16 more reported names
p-Phenylenediamine, N,N-diethyl-, sulfate (1:1)N,N-Diethyl-1,4-benzenediamine sulfateUSP19T3GDASiran N,N-diethyl-p-fenylendiaminuN,N-Diethylbenzene-1,4-diammonium sulphateSiran N,N-diethyl-p-fenylendiaminu [Czech]1,4-Benzenediamine, N,N-diethyl-, sulfate4-Amino-N,N-diethylaniline sulphateN,N-Diethyl-p-phenylenediamine sulfate (VAN)NSC-7653EINECS 227-995-6p-Phenylenediamine, N,N-diethyl-, sulfate1,4-Benzenediamine, N1,N1-diethyl-, sulfate (1:?)N,N-DIETHYLBENZENE-1,4-DIAMINE SULFATEColour developer 1RefChem:822321
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Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 93-05-0
CAS 93-05-0PubChem CID 7120

N,N-Diethyl-p-phenylenediamine

Reddish brown or black liquid. (NTP, 1992) — CAMEO Chemicals

IUPAC name
4-N,4-N-diethylbenzene-1,4-diamine
Molecular formula
C10H16N2
Molecular weight
164.25 g/mol
Exact mass
164.131348519 Da
XLogP3
2.2
Topological polar surface area
29.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

N,N-Diethyl-1,4-phenylenediamine4-Amino-N,N-diethylaniline4-(Diethylamino)anilinep-(Diethylamino)anilinep-Amino-N,N-diethylanilineN,N-Diethyl-4-aminoanilineDiethylaminoanilineN,N-Diethyl-1,4-benzenediamine
16 more reported names
1,4-Benzenediamine, N1,N1-diethyl-p-Phenylenediamine, N,N-diethyl-Diethyl-para-phenylenediaminepara-AminodiethylanilineN,N-Diethyl 4-phenylenediamine0QQA4DFV2JN,N-Diethyl-para-phenylenediamineNSC-147488N,N-diethyl p-phenylenediamineRefChem:822317202-214-14-amino-N,N-diethylaniline sulfateN1,N1-Diethylbenzene-1,4-diaminep-AminodiethylanilineDiethyl-p-phenylenediamine1,4-Benzenediamine, N,N-diethyl-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Identified ingredients

Key data

CAS
93-05-0 / 6065-27-6 / 6283-63-2
EC
202-214-1 / 227-995-6 / 228-500-6
Annex
II
Entry number
1311

Inventory links for N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products

N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 93-05-0 / 6065-27-6 / 6283-63-2 is the unique numerical identifier assigned to N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N,N-Diethyl-p-phenylenediamine and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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