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ProhibitedBinding ruleINOriginal is EnglishOfficial-source import checked

4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as a

4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

All India recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Conditions and restrictions
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Substance identity

Official source name
4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as a
CAS
4372-02-5; 15086-94-9; 17372-87-1; 15876-39-8
EC
240-005-7
Identity mapping
cas_number
Linked ingredient
PIGMENT RED 90:1 ALUMINUM LAKE
Search this identity across the siteCAS 4372-02-5CAS 15086-94-9CAS 17372-87-1CAS 15876-39-8EC 240-005-7

Linked CosIng identity data

Names and aliases

PIGMENT RED 90:1 ALUMINUM LAKE

CosIng description: Dialuminium tris[2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] (CI 45380)

EU inventory restriction note: II/1334

Recorded cosmetic function: COLORANT, HAIR DYEING

Function pages:COLORANT, HAIR DYEING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets

New Zealand

Permitted list with conditionsProhibited

5 linked records · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 15086-94-9
CAS 15086-94-9PubChem CID 27020

Verified chemistry for CAS 15086-94-9

2',4',5',7'-Tetrabromofluorescein

IUPAC name
2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H8Br4O5
Molecular weight
647.9 g/mol
Exact mass
647.70642 Da
Monoisotopic mass
643.71052 Da
XLogP3
6.2
Topological polar surface area
76.0 Ų
Molecular complexity
645.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Rotatable bonds
0
Heavy atoms
29
Covalent units
1

Names and synonyms reported to PubChem

C.I. Solvent Red 43C.I. 45380:23,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide)CI 45380:2NSC-244436Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-oneSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-
16 more reported names
2',4',5',7'-TETRABROMO-3',6'-DIHYDROXY-3H-SPIRO(2-BENZOFURAN-1,9'-XANTHEN)-3-ONE2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(2-benzofuran-3,9'-xanthene)-1-oneRefChem:1058590CHEBI:86277Solvent Red 43BromoeosinBromeosinEosine acidEosin acidJapan Red 223Japan Red No. 223Eosin Y free acidD and C Red No. 21D & C Red no. 21Acid eosinD&C Red No. 21
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
5
3D hydrophobes
4
3D acceptor features
2
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.4
Machine-readable structure identifiers
SMILES
C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C(=C4OC5=C(C(=C(C=C35)Br)O)Br)Br)O)Br
InChI
InChI=1S/C20H8Br4O5/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20/h1-6,25-26H
InChIKey
DBZJJPROPLPMSN-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 17372-87-1
CAS 17372-87-1PubChem CID 11048

Verified chemistry for CAS 17372-87-1

Eosin

IUPAC name
disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate
Molecular formula
C20H6Br4Na2O5
Molecular weight
691.9 g/mol
Exact mass
691.67031 Da
Monoisotopic mass
687.67441 Da
Topological polar surface area
89.5 Ų
Molecular complexity
796.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Rotatable bonds
1
Heavy atoms
31
Covalent units
3

Names and synonyms reported to PubChem

Acid red 87Eosin yellowishEosine YellowishEosineEosine GEosin YSSodium eosineBromo acid
16 more reported names
Eosine YBromofluoresceinSodium eosinateBronze BromoCertiqual EosineBromo FluoresceinEosine AEosine JEosine BSEosine DAEosine FAEosine GFEosine OJEosine w/sEosine YBEosine YS
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChIKey
SEACYXSIPDVVMV-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 4372-02-5
CAS 4372-02-5PubChem CID 20388

Verified chemistry for CAS 4372-02-5

Solvent Red 72

IUPAC name
disodium;4',5'-dibromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
Molecular formula
C20H8Br2Na2O5
Molecular weight
534.1 g/mol
Exact mass
533.85134 Da
Monoisotopic mass
531.85339 Da
Topological polar surface area
81.7 Ų
Molecular complexity
585.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Rotatable bonds
0
Heavy atoms
29
Covalent units
3

Names and synonyms reported to PubChem

DibromofluoresceinC.I. Acid Orange 11Eosine 2JBromo Acid YellowishEosine S 104',5'-DibromfluoresceinD and C Orange No. 6C.I. 45370
16 more reported names
EINECS 224-468-27MF02AWG95Fluorescein, 4',5'-dibromo-, disodium saltFluorescein, 4',5'-dibromo-, sodium deriv., sodium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltRefChem:888153SOLVENT RED 72 [INCI]CI 45370 [INCI]BENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, DISODIUM SALTBENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, SODIUM SALT (1:2)CI 45370ORANGE NO. 201SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-, SODIUM SALT (1:2)Acid orange 11UNII-7MF02AWG95
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC=C2C(=C1)C(=O)OC23C4=C(C(=C(C=C4)[O-])Br)OC5=C3C=CC(=C5Br)[O-].[Na+].[Na+]
InChI
InChI=1S/C20H10Br2O5.2Na/c21-15-13(23)7-5-11-17(15)26-18-12(6-8-14(24)16(18)22)20(11)10-4-2-1-3-9(10)19(25)27-20;;/h1-8,23-24H;;/q;2*+1/p-2
InChIKey
REXANTGEEZXBSJ-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex A, entry 1307
Source record ID
annex-a:1307
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
1614
records marked Prohibited
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as a” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex A, entry 1307, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as a. IS 4707 (Part 2):2025 Annex A, entry 1307. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/15901/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source