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Dihydrocoumarin

Canada Hotlist: Dihydrocoumarin

Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Conditions and restrictions
a) Leave-on products | b) Rinse-off products · Maximum concentration: 0.035% | 3.5%

Substance identity

Official source name
Dihydrocoumarin
CAS
119-84-6
EC
204-354-9
Identity mapping
cas_number
Linked ingredient
DIHYDROCOUMARIN
Search this identity across the siteCAS 119-84-6EC 204-354-9

Linked CosIng identity data

Names and aliases

DIHYDROCOUMARIN

EU inventory restriction note: II/427

Recorded cosmetic function: FRAGRANCE, PERFUMING

Function pages:FRAGRANCE, PERFUMING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 119-84-6
CAS 119-84-6PubChem CID 660

Verified chemistry for CAS 119-84-6

Dihydrocoumarin

3,4-dihydrocoumarin is a chromanone that is the 3,4-dihydro derivative of coumarin. It has a role as a plant metabolite. It is functionally related to a coumarin. — ChEBI

IUPAC name
3,4-dihydrochromen-2-one
Molecular formula
C9H8O2
Molecular weight
148.16 g/mol
Exact mass
148.052429494 Da
Monoisotopic mass
148.052429494 Da
XLogP3
1.6
Topological polar surface area
26.3 Ų
Molecular complexity
165.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
0
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

3,4-dihydrocoumarinhydrocoumarinBenzodihydropyronemelilotin2-chromanone1,2-benzodihydropyronemelilotic lactoneMelilotine
16 more reported names
Oxochroman2H-1-Benzopyran-2-one, 3,4-dihydro-Chroman, 2-oxo-DihydrobenzopyroneUsaf do-12Coumarin, 3,4-dihydro-Meliotine2-Hydroxydihydrocinnamic acid lactoneNCI-C55890o-hydroxydihydrocinnamic acid lactoneFEMA No. 2381Hydrocinnamic acid, o-hydroxy-, delta-lactoneNM5K1Y1BT2CHEBI:16151NSC-10121RefChem:91117
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.6
Machine-readable structure identifiers
SMILES
C1CC(=O)OC2=CC=CC=C21
InChI
InChI=1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2
InChIKey
VMUXSMXIQBNMGZ-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match660

Attributed physical-property, hazard, environmental and use annotations.

  • Substance: 3,4-Dihydrocoumarin Source: NTP Technical Reports
  • NTP Technical Report: TR-423: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1993 ) Source: NTP Technical Reports
  • Peer Review Date: 06/23/92 Source: NTP Technical Reports
  • Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: Some Evidence Source: NTP Technical Reports
  • Summary: Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of 3,4-dihydrocoumarin in male F344/N rats based on increased incidences of renal tubule adenomas and focal hyperplasia. The transitional cell carcinomas in two 600 mg/kg males may also have been chemical related. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in female F344/N rats receiving 150, 300, or 600 mg/kg. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in male B6C3F1 mice receiving 200, 400, or 800 mg/kg. There was some evidence of carcinogenic activity in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined).; 3,4-Dihydrocoumarin caused ulcers, hyperplasia, and inflammation of the forestomach, parathyroid gland hyperplasia, and increased severity of nephropathy in male rats. Source: NTP Technical Reports
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (97.4%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1702 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist restricted entry 34
Source record ID
restricted:34
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Dihydrocoumarin” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist restricted entry 34, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Dihydrocoumarin. Hotlist restricted entry 34. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/524/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source