3,4-Dihydrocoumarin, when used as a fragrance ingredient
3,4-Dihydrocoumarin, when used as a fragrance ingredient is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Dihydrocoumarin
3,4-dihydrocoumarin is a chromanone that is the 3,4-dihydro derivative of coumarin. It has a role as a plant metabolite. It is functionally related to a coumarin. — ChEBI
- IUPAC name
- 3,4-dihydrochromen-2-one
- Molecular formula
- C9H8O2
- Molecular weight
- 148.16 g/mol
- Exact mass
- 148.052429494 Da
- XLogP3
- 1.6
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:16151
- ChEMBL:CHEMBL89306
- EPA DTXSID:DTXSID2020474
- PubMed:40784488
- PubMed:29968805
- PubMed:26795242
- PubMed:25027835
- PubMed:22978790
- PubMed:22789709
- PubMed:22719717
- PubMed:22679830
- PubMed:22654578
- PubMed:22590613
- PubMed:22589881
- PubMed:22577559
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 522 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 272 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 271.00 to 272.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 272 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Leaflets Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: White to light yellow, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless crystals Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.169 at 64 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.169 @ 18 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.186-1.192 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: 266 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 130 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 130 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 77 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 25 °C Source: Human Metabolome Database (HMDB)
- Odor: Herbal Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odor similar to coumarin at room temp or reminiscent of nitrobenzene at higher temp. Source: Hazardous Substances Data Bank (HSDB)
- Odor: Coconut odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Hay-like Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 3,4-dihydrocoumarin is a white to pale yellow clear oily liquid with a sweet odor. Solidifies around room temperature. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: White to light yellow liquid; Colorless solid; [HSDB] Low melting solid; mp = 24-26 deg C; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless to pale yellow liquid; coconut-like aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.5563 @ 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.555-1.559 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Slightly soluble in ether and carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1:2.5-3.5 IN 70% ALCOHOL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in chloroform. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in chlorinated solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 3,000 mg/l at 37 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3 mg/mL at 37 °C Source: Human Metabolome Database (HMDB)
- Solubility: Slightly soluble in water; soluble in oil Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 13.4 mmHg at 77 °F ; 19.5 mmHg at 108 °F; 27.4 mmHg at 145 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 13.4 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Substance: 3,4-Dihydrocoumarin Source: NTP Technical Reports
- NTP Technical Report: TR-423: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1993 ) Source: NTP Technical Reports
- Peer Review Date: 06/23/92 Source: NTP Technical Reports
- Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: Some Evidence Source: NTP Technical Reports
- Summary: Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of 3,4-dihydrocoumarin in male F344/N rats based on increased incidences of renal tubule adenomas and focal hyperplasia. The transitional cell carcinomas in two 600 mg/kg males may also have been chemical related. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in female F344/N rats receiving 150, 300, or 600 mg/kg. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in male B6C3F1 mice receiving 200, 400, or 800 mg/kg. There was some evidence of carcinogenic activity in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined).; 3,4-Dihydrocoumarin caused ulcers, hyperplasia, and inflammation of the forestomach, parathyroid gland hyperplasia, and increased severity of nephropathy in male rats. Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (97.4%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1702 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used in perfumes and flavors--has GRAS status in US; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: ...Used in perfumery industry for its haylike odor. Source: Hazardous Substances Data Bank (HSDB)
- Uses: It has GRAS status and can be used as a food flavor ingredient with a sweet caramel-like taste. Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... In woodruff-type flavor compositions. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
3,4-Dihydrocoumarin, when used as a fragrance ingredient
Chemical / IUPAC name
3,4-Dihydrocoumarin; Melilotin
Regulatory information
SCCS opinions
Identified ingredients
Key data
Inventory links for 3,4-Dihydrocoumarin, when used as a fragrance ingredient
Related records for 3,4-Dihydrocoumarin, when used as a fragrance ingredient
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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2,4-Dihydroxy-3-methylbenzaldehyde, when used as a fragrance ingredient
Cyclamen alcohol, when used as a fragrance ingredient
3,7-Dimethyl-2-octen-1-ol (6,7-Dihydrogeraniol), when used as a fragrance ingredient
Benzyl cyanide, when used as a fragrance ingredient
4,6-Dimethyl-8-tert-butylcoumarin, when used as a fragrance ingredient
Alanroot oil (Inula helenium L.) (CAS No 97676-35-2), when used as a fragrance ingredient
Dimethyl citraconate, when used as a fragrance ingredient
5-tert.-Butyl-1,2,3-trimethyl-4,6-dinitrobenzene (Musk Tibetene)
7,11-Dimethyl-4,6,10-dodecatrien-3-one (Pseudomethylionone), when used as a fragrance ingredient
1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene)
6,10-Dimethyl-3,5,9-undecatrien-2-one (Pseudoionone), when used as a fragrance ingredient
What Annex II means for 3,4-Dihydrocoumarin, when used as a fragrance ingredient
3,4-Dihydrocoumarin, when used as a fragrance ingredient is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 3,4-Dihydrocoumarin, when used as a fragrance ingredient
This page summarizes one Annex II record for 3,4-Dihydrocoumarin, when used as a fragrance ingredient from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 3,4-Dihydrocoumarin, when used as a fragrance ingredient, but confirm any final regulatory decision against the current official annex wording and source files.
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