3,4-Dihydrocoumarin, when used as a fragrance ingredient
New Zealand Cosmetic Products Group Standard Schedule 4, reference 427.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- New Zealand Cosmetic Products Group Standard Schedule 4, reference 427.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 3,4-Dihydrocoumarin, when used as a fragrance ingredient
- CAS
- 119-84-6
- EC
- 204-354-9
- Identity mapping
- cas_number
- Linked ingredient
- DIHYDROCOUMARIN
Linked CosIng identity data
Names and aliases
EU inventory restriction note: II/427
Recorded cosmetic function: FRAGRANCE, PERFUMING
Function pages:FRAGRANCE, PERFUMING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordCanada
1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
Current record1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 119-84-6
Dihydrocoumarin
3,4-dihydrocoumarin is a chromanone that is the 3,4-dihydro derivative of coumarin. It has a role as a plant metabolite. It is functionally related to a coumarin. — ChEBI
- IUPAC name
- 3,4-dihydrochromen-2-one
- Molecular formula
- C9H8O2
- Molecular weight
- 148.16 g/mol
- Exact mass
- 148.052429494 Da
- Monoisotopic mass
- 148.052429494 Da
- XLogP3
- 1.6
- Topological polar surface area
- 26.3 Ų
- Molecular complexity
- 165.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:16151
- ChEMBL:CHEMBL89306
- EPA DTXSID:DTXSID2020474
- PubMed:40784488
- PubMed:29968805
- PubMed:26795242
- PubMed:25027835
- PubMed:22978790
- PubMed:22789709
- PubMed:22719717
- PubMed:22679830
- PubMed:22654578
- PubMed:22590613
- PubMed:22589881
- PubMed:22577559
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 3
- 3D rings
- 2
- 3D hydrophobes
- 0
- 3D acceptor features
- 1
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 1
- Effective 3D rotors
- 0.6
Machine-readable structure identifiers
- SMILES
C1CC(=O)OC2=CC=CC=C21- InChI
InChI=1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2- InChIKey
VMUXSMXIQBNMGZ-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 522 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 272 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 271.00 to 272.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 272 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Leaflets Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: White to light yellow, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless crystals Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.169 at 64 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.169 @ 18 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.186-1.192 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: 266 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 130 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 130 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 77 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 25 °C Source: Human Metabolome Database (HMDB)
- Odor: Herbal Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odor similar to coumarin at room temp or reminiscent of nitrobenzene at higher temp. Source: Hazardous Substances Data Bank (HSDB)
- Odor: Coconut odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Hay-like Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 3,4-dihydrocoumarin is a white to pale yellow clear oily liquid with a sweet odor. Solidifies around room temperature. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: White to light yellow liquid; Colorless solid; [HSDB] Low melting solid; mp = 24-26 deg C; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless to pale yellow liquid; coconut-like aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.5563 @ 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.555-1.559 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Slightly soluble in ether and carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1:2.5-3.5 IN 70% ALCOHOL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in chloroform. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in chlorinated solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 3,000 mg/l at 37 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3 mg/mL at 37 °C Source: Human Metabolome Database (HMDB)
- Solubility: Slightly soluble in water; soluble in oil Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 13.4 mmHg at 77 °F ; 19.5 mmHg at 108 °F; 27.4 mmHg at 145 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 13.4 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Substance: 3,4-Dihydrocoumarin Source: NTP Technical Reports
- NTP Technical Report: TR-423: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1993 ) Source: NTP Technical Reports
- Peer Review Date: 06/23/92 Source: NTP Technical Reports
- Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: Some Evidence Source: NTP Technical Reports
- Summary: Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of 3,4-dihydrocoumarin in male F344/N rats based on increased incidences of renal tubule adenomas and focal hyperplasia. The transitional cell carcinomas in two 600 mg/kg males may also have been chemical related. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in female F344/N rats receiving 150, 300, or 600 mg/kg. There was no evidence of carcinogenic activity of 3,4-dihydrocoumarin in male B6C3F1 mice receiving 200, 400, or 800 mg/kg. There was some evidence of carcinogenic activity in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined).; 3,4-Dihydrocoumarin caused ulcers, hyperplasia, and inflammation of the forestomach, parathyroid gland hyperplasia, and increased severity of nephropathy in male rats. Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (97.4%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1702 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used in perfumes and flavors--has GRAS status in US; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: ...Used in perfumery industry for its haylike odor. Source: Hazardous Substances Data Bank (HSDB)
- Uses: It has GRAS status and can be used as a food flavor ingredient with a sweet caramel-like taste. Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... In woodruff-type flavor compositions. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- New Zealand cosmetic product schedules 4–8
- Source reference
- Schedule 4, reference 427, source row 451
- Source record ID
S4-451- Source version
- effective-2026-01-01
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2026-01-01
- Source updated
- 2024-01-01
- Snapshot checked
- 2026-08-30 04:54 UTC
- Validation method
- openpyxl extraction; reviewed per-schedule counts
- SHA-256
4e62e372fb0aad7ac630af8c41fa50b38b52a793fd51b99697a65f8ecce1ae8a
Registered dataset notes
- Dataset coverage
- Prohibited and restricted substances, permitted colorants, preservatives and UV filters
- Authority note
- Official EPA group standard schedules; current market-specific rule source
How this record fits the market dataset
Status distribution
Condition text is present on 747 of 2913 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
New Zealand market context
Complete schedules dataset
Coverage version: Cosmetic Products Group Standard schedules effective 1 January 2026
Schedules 4–8: prohibited, restricted, colourant, preservative and UV-filter entries.
Verification checklist
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
Official market sources
- New Zealand cosmetic product schedules 4–8Official EPA group standard schedules; current market-specific rule source
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “3,4-Dihydrocoumarin, when used as a fragrance ingredient” and every CAS/EC identifier refer to the material in your supplier specification.
- Search exact identity across Schedules 4–8.
- Apply use, concentration and warning conditions.
- Check hazardous-substance classification and Group Standard scope.
- Confirm the latest legal instrument, not only the spreadsheet.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
3,4-Dihydrocoumarin, when used as a fragrance ingredient. Schedule 4, reference 427, source row 451. New Zealand. Source version effective-2026-01-01. CosIng Checker regulatory record: https://cosingchecker.com/regulations/nz/records/7132/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for New Zealand
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: effective-2026-01-01
- Effective date: 2026-01-01
What it does not prove
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source