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Diethylhexyl Adipate

Canada Hotlist: Diethylhexyl Adipate

Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.

All Canada recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Conditions and restrictions
Synonyms or related compounds: DEHA; Dioctyl Adipate; Bis(2-Ethylhexyl)Hexanedioate | a) Leave-on body moisturizers | b) Other cosmetics · Maximum concentration: a) 6.0%

Substance identity

Official source name
Diethylhexyl Adipate
CAS
103-23-1
EC
203-090-1
Identity mapping
cas_number
Linked ingredient
DIETHYLHEXYL ADIPATE
Search this identity across the siteCAS 103-23-1EC 203-090-1

Linked CosIng identity data

Names and aliases

DIETHYLHEXYL ADIPATE

CosIng description: Bis(2-ethylhexyl) adipate

Recorded cosmetic function: FILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Function pages:FILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

1 market dataset
PubChem 2D chemical structure for CAS 103-23-1
CAS 103-23-1PubChem CID 7641

Verified chemistry for CAS 103-23-1

Bis(2-ethylhexyl) adipate

IUPAC name
bis(2-ethylhexyl) hexanedioate
Molecular formula
C22H42O4
Molecular weight
370.6 g/mol
Exact mass
370.30830982 Da
Monoisotopic mass
370.30830982 Da
XLogP3
6.8
Topological polar surface area
52.6 Ų
Molecular complexity
320.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
19
Heavy atoms
26
Covalent units
1

Names and synonyms reported to PubChem

Di(2-ethylhexyl) adipateBis(2-ethylhexyl)hexanedioateDiethylhexyl adipateDEHABEHAPlastomoll DOAVestinol OAEffomoll DOA
16 more reported names
Kodaflex DOAMonoplex DOATruflex DOAAdipol 2EHReomol doaStaflex doaUniflex doaLankroflex DOABisoflex DOACrodamol DOAErgoplast ADDOMollan SRucoflex plasticizer doaWickenol 158Sansocizer DOAPlasthall DOA
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
2
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCCCC(CC)COC(=O)CCCCC(=O)OCC(CC)CCCC
InChI
InChI=1S/C22H42O4/c1-5-9-13-19(7-3)17-25-21(23)15-11-12-16-22(24)26-18-20(8-4)14-10-6-2/h19-20H,5-18H2,1-4H3
InChIKey
SAOKZLXYCUGLFA-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34675

bis(2-ethylhexyl) adipate

A diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers.

Formula
C22H42O4
Average mass
370.574 g/mol
Monoisotopic mass
370.30831 Da
Formal charge
0
  • diester — is a (CHEBI:51307)
  • carboxylic ester — is a (CHEBI:33308)
  • dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
  • plasticiser — has role (CHEBI:79056)
  • 2-ethylhexan-1-ol — has functional parent (CHEBI:16011)
  • adipic acid — has functional parent (CHEBI:30832)
  • plasticiser — has role (CHEBI:79056)
  • diester — is a (CHEBI:51307)
  • carboxylic ester — is a (CHEBI:33308)
  • dicarboxylic acids and O-substituted derivatives — is a (CHEBI:131927)
Additional curated names
bis(2-ethylhexyl) adipateadipic acid bis(2-ethylhexyl) esterBEHAbis(2-ethylhexyl) hexanedioateDEHADi(2-ethylhexyl) adipateDiethylhexyl adipateDioctyl adipate
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-05-16. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7641

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 96.5% (1012 of 1049) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1012 of 1049 companies (only 3.5% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1049 reports by companies from 12 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1012 of 1049 reports by companies.; There are 10 notifications provided by 37 of 1049 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P261, P271, P280, P304+P340, P318, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • GHS Hazard Statements: Not Classified Source: NITE-CMC
  • GHS Hazard Statements: H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Source: NITE-CMC
  • NFPA Health Rating: 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: A whole-fish BCF of 27 was observed for blue-gill fish exposed to bis(2-ethylhexyl) adipate levels of 250 ug/l for a 28-day period(1). According to a classification scheme(2), this measured BCF value suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from a structure estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to be immobile in soil(SRC). The dominant degradation process in the soil environment is expected to be microbial degradation. Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(3,4). Therefore, the dominant degradation process in the soil environment is expected to be microbial degradation(SRC). Volatilization of bis(2-ethylhexyl) adipate from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 4.34X10-7atm-cu m/mole(3). Bis(2-ethylhexyl) adipate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.5X10-7mm Hg(3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49,000(SRC), determined from an estimation method(2), indicates that bis(2-ethylhexyl) adipate is expected to adsorb to suspended solids and sediment in water(SRC). Biodegradation test results indicate that bis(2-ethylhexyl) adipate is readily biodegradable(4). Therefore, the dominant degradation process in the aquatic environment is expected to be microbial degradation(4). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 4.34X10-7 atm-cu m/mole(4). According to a classification scheme(5), a BCF of 27(4), suggests the potential for bioconcentration in aquatic organisms is low. Bis(2-ethylhexyl) adipate is expected to hydrolyze producing 2-ethylhexanol and hexanoic acid(SRC). Estimated hydrolysis half-lives are 3 years and 120 days at pH values of 7 and 8, respectively(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(2-ethylhexyl) adipate, which has a vapor pressure of 8.5X10-7 mm Hg at 20 °C(3), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(2-ethylhexyl) adipate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.63 days(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 °C(4) determined using a structure estimation method(2). Particulate-phase bis(2-ethylhexyl) adipate may be removed from the air by wet and dry deposition(SRC). Bis(2-ethylhexyl) adipate may undergo direct photolysis in the environment, since this compound contains a functional group that can absorb light >290 nm(5). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Anti-caking agent; Fragrance; Plasticizer; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Dispersing agent; Solvent; Polymerization promoter; Fragrance; Plasticizer; Flavoring and nutrient; Fixing agent (mordant); Wetting agent (non-aqueous); Other; Binder; Lubricating agent; Emulsifier; Diluent; Not Known or Reasonably Ascertainable; Laboratory chemicals Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist restricted entry 33
Source record ID
restricted:33
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
90
records marked Restricted
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Diethylhexyl Adipate” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist restricted entry 33, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Diethylhexyl Adipate. Hotlist restricted entry 33. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/523/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source