MANGANESE CITRATE
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese salt (1:?); Citric acid, manganese salt
MANGANESE CITRATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Manganese Citrate
Manganese citrate is a chemical compound of manganese. Manganese is a naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in its pure form, but is found in many types of rocks in combination with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay healthy, as manganese ions act as cofactors for a number of enzymes. (L228, L229) — Toxin and Toxin Target Database (T3DB)
- IUPAC name
- bis(2-hydroxypropane-1,2,3-tricarboxylate);tris(manganese(2+))
- Molecular formula
- C12H10Mn3O14
- Molecular weight
- 543.01 g/mol
- Exact mass
- 542.821184 Da
- Topological polar surface area
- 281.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 14
- Covalent units
- 5
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID301360797
- EPA DTXSID:DTXSID6047496
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: White powder Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: White solid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Soluble in water in presence of sodium citrate Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Oral (L228) ; inhalation (L228) Source: Toxin and Toxin Target Database (T3DB)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Health Effects: Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as Source: Toxin and Toxin Target Database (T3DB)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit Source: Toxin and Toxin Target Database (T3DB)
- Cosmetic Ingredient Review Link: CIR ingredient: Manganese Citrate Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used as feed and food additive and dietary supplement; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Farming (Feed Additives) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Feed additive, food additive, and dietary supplement Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for MANGANESE CITRATE
INCI name
MANGANESE CITRATE
Description
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese salt (1:?); Citric acid, manganese salt
Record provenance
- Inventory reference
- 83758
- Imported identity
- MANGANESE CITRATE
- Source update
- 15/10/2010
Annex records for MANGANESE CITRATE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How MANGANESE CITRATE appears in the CosIng inventory
The CosIng inventory lists MANGANESE CITRATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
MANGANESE CITRATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for MANGANESE CITRATE
This page reproduces the CosIng inventory entry for MANGANESE CITRATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research MANGANESE CITRATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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