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Official EU label nameGlossary entry 15968

MANGANESE CITRATE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

Resolved substance identity

CAS:10024-66-5
EC:233-027-3
Ingredient index records:
MANGANESE CITRATE
Cosmetic functions: SKIN CONDITIONING

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese salt (1:?); Citric acid, manganese salt

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1 matched or reported name
MANGANESE CITRATE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name MANGANESE CITRATE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

Check the markets and their sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 10024-66-5
CAS 10024-66-5PubChem CID 9937209

Manganese Citrate

Manganese citrate is a chemical compound of manganese. Manganese is a naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in its pure form, but is found in many types of rocks in combination with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay healthy, as manganese ions act as cofactors for a number of enzymes. (L228, L229) — Toxin and Toxin Target Database (T3DB)

IUPAC name
bis(2-hydroxypropane-1,2,3-tricarboxylate);tris(manganese(2+))
Molecular formula
C12H10Mn3O14
Molecular weight
543.01 g/mol
Exact mass
542.821184 Da
Topological polar surface area
281.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
14
Covalent units
5
Defined stereocentres
0

Also known as

Trimanganese dicitrateManganese citrate anhydrous74NE0422XHEINECS 233-193-7Citric acid, manganese salt1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese saltMANGANESE CITRATE [FCC]HSDB 2147
16 more reported names
MANGANESE CITRATE [WHO-DD]Citric acid, manganese(3+) salt (1:1)manganese(3+) ion 2-hydroxypropane-1,2,3-tricarboxylateManganese citric acid1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese(3+) saltRefChem:809845MANGANESE CITRATE [INCI]1,2,3Propanetricarboxylic acid, 2hydroxy, manganese(3+) saltManganese(II) citrateUNII-74NE0422XH1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese(2+) salt (2:3)2-hydroxypropane-1,2,3-tricarboxylate;manganese(2+)MANGANESECITRATEDECAHYDRATEOAVRWNUUOUXDFH-UHFFFAOYSA-HDB-251517Manganese(II) 2-hydroxypropane-1,2,3-tricarboxylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match9937209

Attributed physical-property, hazard, environmental and use annotations.

  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Health Effects: Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as Source: Toxin and Toxin Target Database (T3DB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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