Official EU label nameGlossary entry 6412
CI 45350
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 6 of 13 indexed market datasets: 6 country records and 1 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
6
Evidence gaps
7
Resolved identifiers
7
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
CAS:518-47-82321-07-56417-85-2518-45-6
EC:208-253-0219-031-8229-143-9
Ingredient index records:
CI 45350
Cosmetic functions: COLORANT
Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate
Inventory restriction note: IV/74 (CI 45350) II/1332 (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye products
ACID YELLOW 73 SODIUM SALT
Cosmetic functions: HAIR DYEING
Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate (CI 45350)
Inventory restriction note: II/1332 (when used as a substance in hair dye products)
10 matched or reported names
CI 45350fluorescein sodiumACID YELLOW 73 SODIUM SALTDisodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoateDisodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate (Acid Yellow 73, fluorescein)2-(6-Hydroxy-3-oxo-(3H)xanthen-9-yl)benzoic acid (fluorescein) and its disodium salt (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye products2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; FluoresceinÁcido 2-(6-hidroxi-3-oxo-(3H)xanten-9-il) benzoico; Fluoresceina e seu sal dissódico (Amarelo Ácido 73 sal de sódio; CI 45350), quando usado como substância que entra na composição de corantes capilares2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; Fluorescein (CAS No.2321-07-5) and its disodium salt (Acid yellow 73 sodium salt; CI 45350) (CAS No. 518-47-8), when used as a substance2-(6-Hydroxy-3-oxo-(3H)xanthen-9-yl)benzoic acid; Fluorescein and its disodium salt (Acid Yellow 73 sodium salt; CI 45350), when used as a substance in hair dye products
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Conditional positive-list match | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | No local match | 0 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | Prohibited | 2Open record 1Open record 2 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | Prohibited | 1Open record 1 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | No local match | 0 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Korean source wording is canonical and other positive lists/notices may still apply to the formulation. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | Prohibited | 1Open record 1 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | Review every linked record and exact conditions. |
| India IN | Prohibited | 1Open record 1 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | Review every linked record and exact conditions. |
| Saudi Arabia SA | Prohibited | 1Open record 1 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
No market rows match this filter.
Matching market records and conditions
New Zealand
Cosmetic Products Group Standard schedules effective 1 January 2026Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate (Acid Yellow 73, fluorescein)Permitted list with conditions
Colour index: 45350 · CAS: 518-47-8 · Colour: Yellow · Maximum concentration: 6%
Schedule 6, reference 74, source row 76 · effective-2026-01-01
2-(6-Hydroxy-3-oxo-(3H)xanthen-9-yl)benzoic acid (fluorescein) and its disodium salt (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye productsProhibited
Schedule 4, reference 1332, source row 1403 · effective-2026-01-01
ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026Brazil
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026India
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Exact Annex II–VI evidence
Chemical identity and properties
CAS 2321-07-5PubChem CID 16850
Fluorescein
- IUPAC name
- 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
- Molecular formula
- C20H12O5
- Molecular weight
- 332.3 g/mol
- Exact mass
- 332.06847348 Da
- XLogP3
- 3.4
- Topological polar surface area
- 76.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Solvent Yellow 94ResorcinolphthaleinYellow fluoresceinFluoresceineFluorescein acid3,6-FluorandiolD&C Yellow No. 73',6'-Dihydroxyfluoran
16 more reported names
Japan Yellow 201D and C Yellow No. 7C.I. Solvent Yellow 94Soap Yellow FHidacid fluoresceinYellow 7FluoreszeinFluorescein RedD+C Yellow No. 711712 YellowCHEBI:31624Japan Yellow No. 201Zlut kysela 733',6'-FluorandiolKi201NSC-667256
External database identifiers
- ChEBI:CHEBI:31624
- ChEMBL:CHEMBL1057
- EPA DTXSID:DTXSID0038887
- PubMed:23120194
- PubMed:23115148
- PubMed:23109801
- PubMed:23106861
- PubMed:23105641
- PubMed:23096146
- PubMed:23093817
- PubMed:23091763
- PubMed:23091408
- PubMed:23084247
- PubMed:23083196
- PubMed:23080316
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 518-45-6PubChem CID 3383
2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- IUPAC name
- 2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
- Molecular formula
- C20H12O5
- Molecular weight
- 332.3 g/mol
- Exact mass
- 332.06847348 Da
- XLogP3
- 2.4
- Topological polar surface area
- 83.8 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
flourescein1flr2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID2-(6-oxido-3-oxo-3H-xanthen-9-yl)benzoate2-(3-hydroxy-6-oxo-xanthen-9-yl)benzoic acid2-(6-hydroxy-3-oxoxanthen-9-yl)benzoic acid1n0sfluorescein (acid form)
16 more reported names
cid_3383CBDivE_002901CHEBI:172923HMS3752I07EBC-12373TG2-210NS-05493EN300-1728452-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoesaure2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoicacid2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid #3H-Xanthen-3-one, 6-hydroxy-10-[2-carboxyphenyl]-3',6'-Dihydroxy-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one(3H)Xanthen-3-one, 10-deshydro-6-hydroxy-10-[2-carboxyphen-1-yl]-3'',6''-dihydroxyspiro[1,3-dihydroisobenzofuran-1,9''-(9''H-xanthene)]-3-one
External database identifiers
- ChEBI:CHEBI:172923
- ChEMBL:CHEMBL177756
- EPA DTXSID:DTXSID601031482
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 518-47-8PubChem CID 10608
Sodium Fluorescein
- IUPAC name
- disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
- Molecular formula
- C20H10Na2O5
- Molecular weight
- 376.3 g/mol
- Exact mass
- 376.03236198 Da
- Topological polar surface area
- 89.5 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 5
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Fluorescein disodium saltSoluble fluoresceinUraninUranine WSSResorcinol phthalein sodiumUranine YellowAk-FluorFluorescein, soluble
16 more reported names
Ki202Sodium fluoresceinateFluoresceinum natricum93X55PE38XD&C Yellow No. 8Funduscein-25Ki202(1)Ki202(2)D & C Yellow no. 8disodium 2-(6-oxido-3-oxo-3H-xanthen-9-yl)benzoateCI 45350CI 45350 (Na salt)3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium saltRetinofluorGlostripsBioglo
External database identifiers
- ChEMBL:CHEMBL1628233
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 6417-85-2PubChem CID 80878
Fluorescein dipotassium
- IUPAC name
- dipotassium;3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
- Molecular formula
- C20H10K2O5
- Molecular weight
- 408.5 g/mol
- Exact mass
- 407.98023638 Da
- Topological polar surface area
- 81.7 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 5
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, dipotassium saltFluorescein, Dipotassium SaltUNII-Z6551U35SAZ6551U35SAEINECS 229-143-9Dipotassium 2-(6-oxido-3-oxoxanthen-9-yl)benzoateSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, dipotassium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, potassium salt (1:2)
10 more reported names
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, potassium salt (1:2)RefChem:200981DIPOTASSIUM FLUORESCEINUranine Kdipotassium 3-oxo-3h-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolatePotassium 3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)Potassium fluoresceinURANINEKDZSPMLRDMGJVAT-UHFFFAOYSA-LDipotassium 3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-3',6'-bis(olate)
External database identifiers
- EPA DTXSID:DTXSID9064348
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
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Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identityFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identityILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identityJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identityNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
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Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identityUS EPA CompTox CTX APIs
DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
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2. Review restrictions
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3. Verify the formula
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Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision