What does the restriction note for SOLVENT RED 72 mean?

The restriction field for SOLVENT RED 72 reads: II/1333 (when used as a substance in hair dye products). This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

How do I check if my formula contains SOLVENT RED 72?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7854112/08/2020

SOLVENT RED 72

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (CI 45370)

SOLVENT RED 72 is linked to 2 EU annex records on this page. Inventory note: II/1333 (when used as a substance in hair dye products).

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	2	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 4372-02-5

CAS 4372-02-5PubChem CID 20388

Solvent Red 72

IUPAC name: disodium;4',5'-dibromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

Molecular formula: C20H8Br2Na2O5
Molecular weight: 534.1 g/mol
Exact mass: 533.85134 Da
Topological polar surface area: 81.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 3
Defined stereocentres: 0

Also known as

DibromofluoresceinC.I. Acid Orange 11Eosine 2JBromo Acid YellowishEosine S 104',5'-DibromfluoresceinD and C Orange No. 6C.I. 45370

16 more reported names

EINECS 224-468-27MF02AWG95Fluorescein, 4',5'-dibromo-, disodium saltFluorescein, 4',5'-dibromo-, sodium deriv., sodium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltRefChem:888153SOLVENT RED 72 [INCI]CI 45370 [INCI]BENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, DISODIUM SALTBENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, SODIUM SALT (1:2)CI 45370ORANGE NO. 201SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-, SODIUM SALT (1:2)Acid orange 11UNII-7MF02AWG95

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External database identifiers

EPA DTXSID:DTXSID40933520

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 596-03-2

CAS 596-03-2PubChem CID 11689

D & C Orange No. 5

IUPAC name: 4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

Molecular formula: C20H10Br2O5
Molecular weight: 490.1 g/mol
Exact mass: 489.88745 Da
XLogP3: 4.8
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

4',5'-DibromofluoresceinEosinic acidJapan Orange 201D&C Orange No. 54',5'-DibromofluororesceinC.I. 45370:1CCRIS 4900DAIDAI201

16 more reported names

EINECS 209-876-0BRN 00571895P3H5X9X4QJapan Orange No. 2014',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one5-19-06-00462 (Beilstein Handbook Reference)orange 5Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-4',5'-DIBROMOFLUORESCEIN [MI]4',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium salt4',5'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-oneRefChem:581446DC ORANGE NO. 5ORANGE 5 [INCI]DAIDAI201 [INCI]

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External database identifiers

ChEMBL:CHEMBL3561473
EPA DTXSID:DTXSID7024904

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SOLVENT RED 72

INCI name

SOLVENT RED 72

Description

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (CI 45370)

Record provenance

Inventory reference: 78541
Imported identity: SOLVENT RED 72
Source update: 12/08/2020

European Commission CosIng source notes

Annex records for SOLVENT RED 72

Annex II Restriction reference

Entry 1333

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluores…

CAS: 596-03-2 -- 4372-02-5

EC: 209-876-0 -- 224-468-2

Annex IV Identified ingredient

Entry 75

CI 45370

CAS: 596-03-2; 4372-02-5

EC: 209-876-0; 224-468-2

Key data

CAS

596-03-2 / 4372-02-5

209-876-0 / 224-468-2

Restriction

II/1333 (when used as a substance in hair dye products)

Function

COLORANT: Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.
HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27216 · SOLVENT RED 72

Ingredients with overlapping formulation functions

SOLVENT GREEN 7COLORANT, HAIR DYEING

SOLVENT RED 24COLORANT

SOLVENT RED 48COLORANT

SOLVENT RED 49:1COLORANT

SPHINGOMONAS OLEI EXTRACT FILTRATECOLORANT

SR-(SILKWORM POLYPEPTIDE-1 SERINYL LITHOPHYLLON CONCINNA POLYPEPTIDE-1 DIPEPTID…COLORANT; SLIP MODIFIER

STREPTOMYCES RUBROVINUS FERMENT EXTRACTBLEACHING; COLORANT

SUNSET YELLOWCOLORANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SOLVENT RED 72 appears in the CosIng inventory

The CosIng inventory lists SOLVENT RED 72 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SOLVENT RED 72 is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SOLVENT RED 72 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for SOLVENT RED 72 reads: "II/1333 (when used as a substance in hair dye products)". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, SOLVENT RED 72 carries the following function designation(s):

CAS 596-03-2 / 4372-02-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for SOLVENT RED 72

This page combines the CosIng inventory entry for SOLVENT RED 72 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research SOLVENT RED 72 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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