Skip to main content
InventoryRef 3426006/08/2020

HEXAMIDINE DIISETHIONATE

2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

HEXAMIDINE DIISETHIONATE is linked to 1 EU annex record on this page. Inventory note: V/47.

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

Compare markets

Swipe or scroll horizontally to see every column.

MarketEvidence statusRecordsSource language
European UnionEvidence linked
Positive-list entry with conditions
Open this evidence
1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandEvidence linked
Permitted list with conditions
Open this evidence
1English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 659-40-5
CAS 659-40-5PubChem CID 3080571

Hexamidine Diisethionate

Hexamidine and Hexamidine Diisethionate are safe for the use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%. Cosmetic Ingredient Review (CIR)

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(2-hydroxyethanesulfonic acid)
Molecular formula
C24H38N4O10S2
Molecular weight
606.7 g/mol
Exact mass
606.20293577 Da
Topological polar surface area
284.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
12
Covalent units
3
Defined stereocentres
0

Also known as

Hexamidine isethionatehexomedinhexamidine isetionate023XA5Z50LNSC-115848RF-2535Laryngomedin NHexomedin N
16 more reported names
RefChem:146090211-533-5DesomedineHexamidine diisetionate4,4'-(Hexane-1,6-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)HexomedineOphtamedineEsomedina2-HYDROXYETHANESULPHONIC ACID, COMPOUND WITH 4,4'-[HEXANE-1,6-DIYLBIS(OXY)]BIS[BENZENECARBOXAMIDINE] (2:1)2535 RPRP 25354-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (22535 R. P.DesmedineUNII-023XA5Z50L

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HEXAMIDINE DIISETHIONATE

INCI name

HEXAMIDINE DIISETHIONATE

Description

2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

Record provenance

Inventory reference
34260
Imported identity
HEXAMIDINE DIISETHIONATE
Source update
06/08/2020
European Commission CosIng source notes

Key data

Restriction
V/47
Function
ANTI-SEBORRHEIC
Preventing or relieving the symptoms of seborrhea and/or seborrheic dermatitis, including dandruff.
ANTIMICROBIAL
Preventing and/or slowing down microbial growth.
PRESERVATIVE
Exclusively or mainly intended to inhibit the development of micro-organisms in the cosmetic product. All authorised preservatives are substances in the positive list of Annex V to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How HEXAMIDINE DIISETHIONATE appears in the CosIng inventory

The CosIng inventory lists HEXAMIDINE DIISETHIONATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HEXAMIDINE DIISETHIONATE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HEXAMIDINE DIISETHIONATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for HEXAMIDINE DIISETHIONATE reads: "V/47". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, HEXAMIDINE DIISETHIONATE carries the following function designation(s):

CAS 659-40-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for HEXAMIDINE DIISETHIONATE

This page combines the CosIng inventory entry for HEXAMIDINE DIISETHIONATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research HEXAMIDINE DIISETHIONATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

Check your formula

Scan a full INCI list to detect HEXAMIDINE DIISETHIONATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to HEXAMIDINE DIISETHIONATE, its identifiers or nearby name variants.

Search