Annex V Entry 18 16/10/2010

UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE

Q: How is the maximum concentration of UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE calculated in a finished product?

The maximum concentration of 0.2% (as acid) applies to the substance in the ready-to-use cosmetic product. When supplied as part of a blend or mixture, the calculation must account for contributions from all sources in the formulation.

Q: How do I check if my product formula contains UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Undec-10-enoic acid and its salts

UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.2% (as acid).

Permitted preservative— Annex V, EU Regulation 1223/2009

Max conc.: 0.2% (as acid)

Entry: 18

Chemical identity and properties

PubChem 2D chemical structure for CAS 112-38-9

CAS 112-38-9PubChem CID 5634

Undecylenic Acid

10-undecenoic acid is an undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems. It has a role as a plant metabolite and an antifungal drug. It is a conjugate acid of a 10-undecenoate. — ChEBI

IUPAC name: undec-10-enoic acid

Molecular formula: C11H20O2
Molecular weight: 184.27 g/mol
Exact mass: 184.146329876 Da
XLogP3: 3.9
Topological polar surface area: 37.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

10-UNDECENOIC ACID10-Hendecenoic acidRenselinDeclidSevinon10-Undecylenic acidundecylenateFEMA No. 3247

16 more reported names

Kyselina undecylenovaUNDECEN-10-ACID-1omega-undecenoic acidomega-hendecenoic acidNSC-2013K3D86KJ24NCHEBI:35045NSC2013DesinexMicocilenSanafitilTobcharmAntifungal PenHongo KillerRemedy NailsSally Hansen

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:35045
ChEMBL:CHEMBL1276010
EPA DTXSID:DTXSID8035001
PubMed:26902505
PubMed:26776224
PubMed:22947450
PubMed:22907042
PubMed:22904206
PubMed:22717557
PubMed:22713167
PubMed:22704888
PubMed:22652355
PubMed:22447430
PubMed:22433058
PubMed:22396902

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match5634

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: Decomposes at 275°C Source: DrugBank
Boiling Point: 137.00 °C. @ 2.00 mm Hg Source: Human Metabolome Database (HMDB)
Boiling Point: 275 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Density: 0.910 - 0.917 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

LogP: 3.86 Source: Human Metabolome Database (HMDB)

Melting Point: 24.5 Source: DrugBank
Melting Point: 24.5 °C Source: Human Metabolome Database (HMDB)

Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
Physical Description: Liquid or solid; mp = 24.5 deg C; [Merck Index] Colorless or white liquid or low-melting solid; mp = 25-27 deg C; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Solid Source: Human Metabolome Database (HMDB)
Physical Description: colourless to pale yellow liquid Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Refractive Index: 1.446-1.453 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: Insoluble Source: DrugBank
Solubility: 0.0737 mg/mL at 30 °C Source: Human Metabolome Database (HMDB)
Solubility: insoluble in water; soluble in alcohol and ether Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)

Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H400 (10.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H412 (96.2%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1915 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use andconcentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be basedon a QRA...Undecylenic Acid... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Industry Uses: Intermediate Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Undecylenic Acid Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used as a topical antifungal agent; [Merck Index] Used as a flavoring agent for foods; [JECFA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1322-14-1

CAS 1322-14-1PubChem CID 14865

Calcium Undecylenate

Calcium Undecylenate is the calcium salt of undecylenic acid, an 11 carbon mono-unsaturated fatty acid with broad-spectrum antifungal activity. Undecylenic acid inhibits the morphogenesis of Candida albicans to its invasive fungal form and inhibits the conversion of unicellular yeast to their hyphal form. — NCI Thesaurus (NCIt)

IUPAC name: calcium bis(undec-10-enoate)

Molecular formula: C22H38CaO4
Molecular weight: 406.6 g/mol
Exact mass: 406.2396005 Da
Topological polar surface area: 80.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 3
Defined stereocentres: 0

Also known as

Undecylenate calciumCALCIUM UNDECENOATE77YW1RTU8VCALCIUM 10-UNDECENOATECALCIUM UNDECENOATE (MART.)CALCIUM UNDECENOATE [MART.]CALCIUM UNDECYLENATE (USP MONOGRAPH)CALCIUM UNDECYLENATE [USP MONOGRAPH]

16 more reported names

HEALTHA CleanRefChem:54634GN MEDI ANTIBACTERIALSPRAY215-331-8Calcium diundec-10-enoatecalcium;undec-10-enoateCruex10-Undecenoic acid, calcium saltCal-DeseneUNII-77YW1RTU8VCalcium undecylenate (USP)Calcium undecylenate [USAN:USP]EINECS 215-331-8CLOKKBBIKHZGNX-UHFFFAOYSA-LCALCIUM UNDECYLENATE [USAN]UNDECYLENATE CALCIUM [VANDF]

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External database identifiers

ChEMBL:CHEMBL2104130

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3398-33-2

CAS 3398-33-2PubChem CID 23667258

Sodium Undecylenate

The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use andconcentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be basedon a QRA...Sodium Undecylenate... — Cosmetic Ingredient Review (CIR)

IUPAC name: sodium undec-10-enoate

Molecular formula: C11H19NaO2
Molecular weight: 206.26 g/mol
Exact mass: 206.12827413 Da
Topological polar surface area: 40.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 2
Defined stereocentres: 0

Also known as

Undecylenic Acid Sodium Salt10-Undecenoic acid, sodium saltUNII-V50TG7E11WV50TG7E11WSODIUM UNDECYLENATE [VANDF]EINECS 222-264-8SODIUM UNDECYLENATE [WHO-DD]10-Undecenoic, sodium salt

16 more reported names

AI3-1972110-Hendecenoic acid, sodium saltSODIUM UNDECYLENATE [INCI]NSC 2836NSC-2836Sodium undec10enoateRefChem:18415010Undecenoic, sodium salt682-768-2sodium;undec-10-enoateSodium 10-undecenoateSODIUM DERIVATIVE OF 10-UNDECENOATESodium undecylenate, AldrichCPRNSC2836HY-W12745210-Undecenoic acid, sodium salt (1:1)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID4037039

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 56532-40-2

CAS 56532-40-2PubChem CID 25494

Undecylenic acid monoethanolamine

The CIR Expert Panel concluded that ethanolamine and the 12 related ethanolamine salts, listed below, are safe in the present practices of use and concentration described in this safety assessment (rinse-off products only) when formulated to be non-irritating. The Panel cautioned that ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...MEA-Undecylenate... — Cosmetic Ingredient Review (CIR)

IUPAC name: 2-aminoethanol;undec-10-enoic acid

Molecular formula: C13H27NO3
Molecular weight: 245.36 g/mol
Exact mass: 245.19909372 Da
Topological polar surface area: 83.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

MEA-UNDECYLENATEUndec-10-enoic acid, compound with 2-aminoethanol (1:1)EINECS 260-247-789FB3I7256MONOETHANOLAMINE UNDECYLENATEETHANOL, 2-AMINO-, 10-UNDECENOATE (SALT)RefChem:901088MEA-UNDECYLENATE [INCI]

2 more reported names

UNII-89FB3I7256Undec-10-enoic acid--2-aminoethan-1-ol (1/1)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID20971980

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6159-41-7

CAS 6159-41-7PubChem CID 23692638

Potassium Undecylenate

The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use andconcentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be basedon a QRA...Potassium Undecylenate... — Cosmetic Ingredient Review (CIR)

IUPAC name: potassium undec-10-enoate

Molecular formula: C11H19KO2
Molecular weight: 222.37 g/mol
Exact mass: 222.10221133 Da
Topological polar surface area: 40.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 2
Defined stereocentres: 0

Also known as

Undecylenic acid, potassium salt768M7EX694UNII-768M7EX694RefChem:175641POTASSIUM UNDECYLENATE [INCI]662-949-2potassium;undec-10-enoateDEXGNWRKHMRIRB-UHFFFAOYSA-M

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External database identifiers

EPA DTXSID:DTXSID50210591

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 84471-25-0

CAS 84471-25-0PubChem CID 44148605

10-Undecenoic acid, compd. with 2,2',2''-nitrilotris(ethanol) (1:1)

IUPAC name: 2-[bis(2-hydroxyethyl)amino]ethanol;undec-10-enoic acid

Molecular formula: C17H35NO5
Molecular weight: 333.5 g/mol
Exact mass: 333.25152322 Da
Topological polar surface area: 101.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 6
Covalent units: 2
Defined stereocentres: 0

Also known as

Undec-10-enoic acid, compound with 2,2',2''-nitrilotriethanol (1:1)RefChem:1057253282-908-9EINECS 282-908-9Undec-10-enoic acid--2,2',2''-nitrilotri(ethan-1-ol) (1/1)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID90233441

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.2% (as acid)

INCI glossary name

UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE

Chemical name

Undec-10-enoic acid and its salts

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Opinion concerning Restrictions on Materials listed in annex VI of Directive 76/768/EEC on Cosmetic Products

Identified ingredients

Key data

CAS

112-38-9 / 6159-41-7 / 3398-33-2 / 1322-14-1 / 84471-25-0 / 56532-40-2

203-965-8 / - / 222-264-8 / 215-331-8 / 282-908-9 / 260-247-7

Annex

Entry number

Inventory links for UNDECYLENIC ACID / POTASSIUM UNDECYLENATE / SODIUM UNDECYLENATE / CALCIUM UNDECYLENATE / MEA-UNDECYLENATE / TEA-UNDECYLENATE

Inventory Restriction reference

Ref 32354

CALCIUM UNDECYLENATE

CAS: 1322-14-1

EC: 215-331-8

Inventory Restriction reference

Ref 35193

MEA-UNDECYLENATE

CAS: 56532-40-2

EC: 260-247-7

Inventory Restriction reference

Ref 37039

POTASSIUM UNDECYLENATE

CAS: 6159-41-7

Inventory Restriction reference

Ref 38116

SODIUM UNDECYLENATE

CAS: 3398-33-2

EC: 222-264-8

Inventory Restriction reference

Ref 38538

TEA-UNDECYLENATE

CAS: 84471-25-0

EC: 282-908-9

Inventory Restriction reference

Ref 38829

UNDECYLENIC ACID

CAS: 112-38-9

EC: 203-965-8

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 17