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Annex IV Entry 71 14/08/2020

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

CI 45100/ ACID RED 52

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt appears in Annex IV as a positive-list colorant entry for EU cosmetics. Maximum concentration in this record: Rinse-off products.

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Permitted colorant— Annex IV, EU Regulation 1223/2009
Max conc.: Rinse-off products
Entry: 71

Chemical identity and properties

PubChem 2D chemical structure for CAS 3520-42-1
CAS 3520-42-1PubChem CID 9916275

Acid Red 52

Lissamine rhodamine is an organic sodium salt having 4-[3,6-bis(diethylamino)xanthenium-9-yl]benzene-1,3-disulfonate as the counterion. It has a role as a fluorescent probe, a fluorochrome and a histological dye. It contains a lissamine rhodamine anion. — ChEBI

IUPAC name
sodium 4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzene-1,3-disulfonate
Molecular formula
C27H29N2NaO7S2
Molecular weight
580.7 g/mol
Exact mass
580.13138790 Da
Topological polar surface area
147.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Covalent units
2
Defined stereocentres
0

Also known as

C.I. Acid Red 52Acid Rhodamine BLissamine RhodamineKiton Rhodamine BXylene Red BAmido Rhodamine BAcid Red XBFood Red 106
16 more reported names
Fenazo Pink XXBSolar Rhodamine BAmacid Rhodamine BErio Acid Red XBErio Acid Red XBCRed No. 106Acid Leather Red KBAizen Food Red No. 106Pontacyl Brilliant PinkBrilliant Acid Rhodamine BCI 45100Red 106Brilliant Superlan Rhodamine BBrilliant Superlan Rhodamine 2B821LWZ3R6RVIBRACOLOR RED ARE52
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

Rinse-off products

Colour index or glossary

CI 45100/ ACID RED 52

Chemical name

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

Chemical / IUPAC name

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

Color

Red

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

  • Opinion on Acid Red 52
  • Opinion on Acid Red 52

Identified ingredients

Key data

CAS
3520-42-1
EC
222-529-8
Annex
IV
Entry number
71

Inventory links for Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

Inventory Restriction reference
Ref 31630

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Inventory Restriction reference
Ref 32764

CI 45100

CAS: 3520-42-1
EC: 222-529-8

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex III 193
Shared CAS number

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex IV 70
Nearby record in the same annex

CI 44090

CAS: 3087-16-9
EC: 221-409-2
Annex IV 69
Nearby record in the same annex

CI 44045

CAS: 2580-56-5
EC: 219-943-6
Annex IV 73
Nearby record in the same annex

CI 45220

CAS: 5873-16-5
EC: 227-528-6
Annex IV 68
Nearby record in the same annex

CI 42735

CAS: 6505-30-2
EC: 229-390-2
Annex IV 74
Nearby record in the same annex

CI 45350

CAS: 518-45-6; 518-47-8
EC: -; 208-253-0
Annex IV 75
Nearby record in the same annex

CI 45370

CAS: 596-03-2; 4372-02-5
EC: 209-876-0; 224-468-2
Annex IV 66
Nearby record in the same annex

CI 42510

CAS: 632-99-5
EC: 211-189-6
Annex IV 76
Nearby record in the same annex

CI 45380 / ACID RED 87

CAS: 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
EC: 241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2
Annex IV 65
Nearby record in the same annex

CI 42170

CAS: 5863-51-4
EC: 227-513-4

What Annex IV means for Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm colorant is used only in permitted product types listed above.
  • Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 3520-42-1 is the unique numerical identifier assigned to Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of Rinse-off products applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex IV record Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt

This page summarizes one Annex IV record for Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt, but confirm any final regulatory decision against the current official annex wording and source files.

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