EU cosmetic ingredients, restrictions and safety

Annex IV Entry 77 14/08/2020

3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

CI 45396

3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one appears in Annex IV as a positive-list colorant entry for EU cosmetics.

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Permitted colorant— Annex IV, EU Regulation 1223/2009

Entry: 77

Record details

Other restrictions

1%, when used in lip products

Warnings

Only in free acid form, when used in lip products

Colour index or glossary

CI 45396

Chemical name

3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Chemical / IUPAC name

3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Color

Orange

Regulatory information

Regulation

(EC) 2009/1223

Identified ingredients

CI 45396

Key data

CAS

EC

Annex

Entry number

77

Inventory links for 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Inventory Restriction reference

Ref 32770

CI 45396

CAS: 24545-86-6

EC: 246-308-0

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex IV 76

Nearby record in the same annex

CI 45380 / ACID RED 87

CAS: 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3

EC: 241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2

Annex IV 78

Nearby record in the same annex

CI 45405

CAS: 6441-77-6

EC: 229-225-4

Annex IV 75

Nearby record in the same annex

CI 45370

CAS: 596-03-2; 4372-02-5

EC: 209-876-0; 224-468-2

Annex IV 79

Nearby record in the same annex

CI 45410

CAS: 18472-87-2

EC: 242-355-6

Annex IV 74

Nearby record in the same annex

CI 45350

CAS: 518-45-6; 518-47-8

EC: -; 208-253-0

Annex IV 80

Nearby record in the same annex

CI 45430

CAS: 12227-78-0

EC: 240-474-8

Annex IV 73

Nearby record in the same annex

CI 45220

CAS: 5873-16-5

EC: 227-528-6

Annex IV 81

Nearby record in the same annex

CI 47000 / SOLVENT YELLOW 33

CAS: 8003-22-3

EC: 232-318-2

Annex IV 72

Nearby record in the same annex

CI 45190 / ACID VIOLET 9

CAS: 6252-76-2

EC: 228-377-9

Annex IV 82

Nearby record in the same annex

CI 47005

CAS: 38615-46-2 ; 8004-92-0; 95193-83-2

EC: -; -; 305-897-5

Annex IV 71

Nearby record in the same annex

CI 45100/ ACID RED 52

CAS: 3520-42-1

EC: 222-529-8

Annex IV 83

Nearby record in the same annex

CI 50325

CAS: 6837-46-3; 6856-08-2

EC: -; 229-951-1

What Annex IV means for 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Confirm colorant is used only in permitted product types listed above.
Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 24545-86-6 is the unique numerical identifier assigned to 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex IV record 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

This page summarizes one Annex IV record for 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for 3',6'-Dihydroxy-4',5'-dinitrospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one, but confirm any final regulatory decision against the current official annex wording and source files.

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