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Annex III Source last update: 02/03/2026

Restricted cosmetic substances

LIST OF SUBSTANCES WHICH COSMETIC PRODUCTS MUST NOT CONTAIN EXCEPT SUBJECT TO THE RESTRICTIONS LAID DOWN

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CosIng Checker is an independent reference website built from publicly available European Commission cosmetic ingredient materials, including Annex II–VI datasets.

Use these pages for research, discovery and comparison, but verify critical regulatory decisions against the official source text and current law.

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Records

373 total
Entry
245

2-AMINO-4-HYDROXYETHYLAMINOANISOLE / 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE

2-[(3-Amino-4-methoxyphenyl)amino]ethanol and its sulphate

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
83763-47-7 / 83763-48-8
EC
280-733-2 / 280-734-8
Product type 14/02/2014
Entry
246

HYDROXYETHYL-3,4-METHYLENEDIOXYANILINE HCL

Hydroxyethyl-3,4-methylenedioxyaniline and its hydrochloride

Hair colourants can use severe allergic reactions Read and folow instructions

CAS
94158-14-2
EC
303-085-5
Product type 29/11/2023
Entry
247

HC BLUE NO 2

2,2'-[[4-[(2-Hydroxyethyl)amino]-3-nitrophenyl]imino]bisethanol (see note 17)

Can cause allergic reaction

CAS
33229-34-4
EC
251-410-3
Max concentration Product type 26/07/2013
Entry
248

3-NITRO-P-HYDROXYETHYLAMINOPHENOL

4-[(2-Hydroxyethyl)amino-3-nitrophenol

For (a) and (b): Hair colourants can use severe allergic reactions Read and follow intructions

CAS
65235-31-6
EC
265-648-0
Max concentration Product type 26/07/2013
Entry
249

4-NITROPHENYL AMINOETHYLUREA

1-(.beta.-Ureidoethyl)amino-4-nitrobenzene

For (a) and (b): Hair colourants can cause severe allergic reactions Read and follow instructions

CAS
27080-42-8
EC
410-700-1
Max concentration Product type 26/07/2013
Entry
25

ZINC PHENOLSULFONATE

Zinc 4-hydroxybenzene sulphonate

Avoid contact with eyes

CAS
127-82-2
EC
204-867-8
Max concentration Product type 17/10/2010
Entry
250

HC RED NO 10 + HC RED NO 11

1-amino-2-nitro-4-(2',3'-dihydroxypropyl)amino-5-chlorobenzene and 1,4-bis-(2',3'-dihydroxypropyl)amino-2-nitro-5-chlorobenzene and its salts

Hair colourants can cause severe allergic reactions Read and folow instructions

CAS
95576-89-9 - 95576-92-4
EC
- -
Max concentration Product type 26/07/2013
Entry
250

HC Red No 10+ HC Red No 11

1-Amino-2-nitro-4-(2', 3'-dihydroxypropyl)amino-5-chloro-benzene + 1,4-bis-(2',3'-dihydroxypropyl)amino-2-nitro-5-chlorobenzene

(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,0% For (a) and (b): - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/KG - Keep in n…

CAS
9556-89-9 - 95576-92-4
EC
—
Max concentration Product type 09/09/2013
Entry
251

2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL

Phenol, 2-Chloro-6-(ethylamino)-4-nitro- and its salts

In combination with hydrogen peroxide the maximum use concentration upon application is 1.5% Not to be used after 31.12.2009

CAS
131657-78-8
EC
411-440-1
Max concentration Product type 18/10/2010
Entry
251

HC RED NO 7

2-(4-Amino-3-nitroanilino)ethanol

Hair colorants can cause severe allergic reactions

CAS
24905-87-1
EC
246-521-9
Max concentration Product type 09/09/2013
Entry
252

2-AMINO-6-CHLORO-4-NITROPHENOL

2-Amino-6-chloro-4-nitrophenol

(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “blac…

CAS
6358-09-4
EC
228-762-1
Max concentration Product type 08/07/2015
Entry
253

HC Yellow No. 4

2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol

— Do not use with nitro­sating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

CAS
59820-43-8
EC
428-840-7
Max concentration Product type 12/08/2020
Entry
253

HC Yellow No 4

2-[bis(2-Hydroxyethyl)amino]-5- nitrophenol

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 micrograme/Kg - Keep in nitrite-free containers

CAS
59820-43-8
EC
428-840-7
Max concentration Product type 09/09/2013
Entry
254

ACID RED 33

Disodium 5-amino-4-hydroxy-3-(phenylazo)naphathlene-2,7-disulphonate (see note 17); (CI 17200)

Hair dye substance in non-oxidative hair dye products

CAS
3567-66-6
EC
222-656-9
Max concentration Product type 14/08/2020
Entry
255

HC Yellow No 2

2-[(2-Nitrophenyl)amino] ethanol

To be printed on the label: Hair colorants can cause allergic reactions.

CAS
4926-55-0
EC
225-555-8
Max concentration Product type 09/09/2013
Entry
256

HC Orange No 1

4-[(2-Nitrophenyl)amino]phenol

Hair day substance in non-oxidative hair dye products

CAS
54381-08-7
EC
259-132-4
Max concentration Product type 09/09/2013
Entry
257

LAURETH-9

Laureth-9

(a) Leave-on products (b) Rinse-off products

CAS
3055-99-0
EC
221-284-4
Max concentration Product type 16/06/2015
Entry
258

HC Red No 1

2-Nitro-N1-phenyl-benzene-1,4- diamine

Hair colorants can cause severe allergic reactions.

CAS
2784-89-6
EC
220-494-3
Max concentration Product type 09/09/2013
Entry
259

HC Yellow No 9

1-Methoxy-3-(β-aminoethyl) amino-4-nitrobenzene, hydrochloride

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers

CAS
86419-69-4
EC
415-480-1
Max concentration Product type 09/09/2013
Entry
26

AMMONIUM MONOFLUOROPHOSPHATE

Ammonium monofluorophosphate

Contains ammonium monofluorophosphate. For any toothpaste with compounds containing fluorine in a concentration of 0,1 to 0,15 % calculated as F unless it is already labelled as contra-indicated for children (e.g. “for…

CAS
20859-38-5 -- 66115-19-3
EC
- -- -
Max concentration Product type 14/05/2013
Entry
260

HC Yellow No 7

1-(4’-Aminophenylazo)-2-methyl- 4-(bis-2-hydroxyethyl) aminobenzene

Hair dye substance in oxidative hair dye products

CAS
104226-21-3
EC
146-420-6
Max concentration Product type 09/09/2013
Entry
261

HC Yellow No 13

N-(2-Hydroxyethyl)-2-nitro-4- trifluormethyl-aniline

To be printed on the label: Hair colorants can cause severe allergic reactions

CAS
10442-83-8
EC
443-760-2
Product type 09/09/2013
Entry
262

BASIC YELLOW 57

Benzenaminium, 3-[(4,5-dihydro- 3-methyl-5-oxo-1-phenyl-1H- pyrazol-4-yl)azo]-N,N,Ntrimethyl-, chloride

Hair dye substance in non-oxidative hair dye products

CAS
68391-31-1
EC
269-943-5
Max concentration Product type 12/02/2014
Entry
263

Disperse Black 9

Ethanol, 2,2′-[[4-[(4-aminophenyl) azo]phenyl]imino]bis-

Hair dye substance in non-oxidative hair dye products

CAS
20721-50-0
EC
243-98-5
Max concentration Product type 09/09/2013
Entry
264

HC Blue No 14

9,10-Anthracenedione, 1,4-bis [(2,3-dihydroxypropyl)amino]-

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers

CAS
99788-75-7
EC
421-470-7
Max concentration Product type 09/09/2013
Entry
265

DISPERSE VIOLET 1

1,4-Diaminoanthraquinone

Impurity of Disperse Red 15 in Disperse Violet 1 for hair dye formulations should be < 1 % (w/w)

CAS
128-95-0
EC
204-922-6
Max concentration Product type 16/06/2014
Entry
266

HC RED No 3

Ethanol, 2-((4- amino-2-nitrophenyl)amino)-

For (a): To be printed on the label: The mixing ratio. For (a) and (b): “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age o…

CAS
2871-01-4
EC
220-701-7
Max concentration Product type 16/06/2014
Entry
267

BASIC RED 76

[7-Hydroxy-8-[(2- methoxyphenyl)azo]-2-naphthyl]trimethylammonium chloride

Hair dye substance non-oxidative hair dye products

CAS
68391-30-0
EC
269-941-4
Max concentration Product type 17/06/2014
Entry
269

2-Amino-5- Ethylphenol HCl

Phenol, 2-Amino- 5-Ethyl-, Hydrochloride

To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black hen…

CAS
—
EC
—
Product type 16/06/2014
Entry
269

BASIC RED 51

2-[[4-(Dimethylamino)phenyl]azo]-1,3- dimethyl-1H-imidazolium chloride

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
77061-58-6
EC
278-601-4
Max concentration Product type 16/06/2014
Entry
27

Sodium monofluorophosphate

Contains sodium monofluorophosphate For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adu…

CAS
10163-15-2 -- 7631-97-2
EC
233-433-0 -- 231-552-2
Max concentration Product type 14/05/2013
Entry
270

ACID RED 92

Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
18472-87-2
EC
242-355-6
Max concentration Product type 14/08/2020
Entry
271

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]ant…

Mixture of (1), (2) & (3) in dispersing agent (lignosulphate): (1) 9,10-Anthracenedione- 1,4-bis[(2- Hydroxyethyl)amino] (2) 9,10-Anthracenedione-1- [(2-Hydroxyethyl)amino]- 4-[(3- Hydroxypropyl)amino] (3) 9,10-anthrace…

Hair dye substance in non-oxidative hair dye products

CAS
(1) 4471-41-4/(2) 67674-26-4/(3) 67701-36-4
EC
(1) 224-743-7/(2) 266-865-3/(3) 266-954-7
Max concentration Product type 16/06/2014
Entry
272

P-AMINOPHENOL

4-Aminophenol

(a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions.This product is not intended for use on persons under the age of 16. Temporary ‘bla…

CAS
123-30-8
EC
204-616-2
Product type 27/07/2020
Entry
273

1-Hydroxyethyl-4,5- Diamino Pyrazole Sulfate

4,5-Diamino-1-(2- hydroxyethyl)-1H- pyrazole

To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna…

CAS
155601-30-2
EC
429-300-3
Product type 16/06/2014
Entry
274

4-Formyl-1-Methylquinolinium-p-Toluenesulfonate

Quinolinium, 4- formyl-1-methyl-, salt with 4- methylbenzenesulfonic acid (1:1)

To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black hen…

CAS
223398-02-5
EC
453-790-8
Product type 16/06/2014
Entry
275

Basic Yellow 87

Pyridinium, 1- methyl-4-[( methylphenylhydrazono)methyl]-, methyl sulfate

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
68259-00-7
EC
269-503-2
Max concentration Product type 16/06/2014
Entry
276

BASIC ORANGE 31

2-[(4-Aminophenyl)azo]-1,3- dimethyl-1H-imidazolium chloride

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
97404-02-9
EC
306-764-4
Max concentration Product type 11/12/2020
Entry
277

2,6-Diamino-3- ((Pyridine-3-yl)azo)Pyridine

2,6-Pyridinediamine, 3-(3- pyridinylazo)

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
28365-08-4
EC
421-430-9
Max concentration Product type 16/06/2014
Entry
278

BASIC VIOLET 2

4-((4-Amino-3- methylphenyl)(4- imino-3-methyl- 2,5-cyclohexadien-1- ylidene)methyl)-2- methylphenylamine monohydrochloride (CI 42520)

a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black …

CAS
3245-91-7
EC
221-831-7
Max concentration Product type 14/08/2020
Entry
279

2,3-Diaminodihydropyrazolopyrazolone Dimethosulfonate

2,3-Diamino-6,7- dihydro-1H,5H- pyrazolo[1,2-a] Pyrazol-1-one dimethanesulfonate

To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black hen…

CAS
857035-95-1
EC
469-500-8
Product type 16/06/2014
Entry
28

Potassium monofluorophosphate

Contains potassium monofluorophosphate For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for …

CAS
14104-28-0
EC
237-957-0
Max concentration Product type 14/05/2013
Entry
280

Picramic Acid and Sodium Picramate

2-Amino-4,6-dinitrophenol and 2- amino-4,6-dinitrophenol, sodium salt

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
96-91-3 / 831-52-7
EC
202-544-6 / 212-603-8
Max concentration Product type 16/06/2014
Entry
281

2-Nitro-5-Glyceryl Methylaniline

1-Methylamino-2- nitro-5-(2,3-dihydroxy-propyloxy)- benzene

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16 Temporary ‘black …

CAS
80062-31-3
EC
279-383-3
Max concentration Product type 16/06/2014
Entry
282

HC Blue 16

1-Propanaminium, 3-[[9,10-dihydro- 4-(methylamino)- 9,10-dioxo-1- anthracenyl] amino]-N,N- dimethyl-N- propyl-, bromide

— Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

CAS
502453-61-4
EC
481-170-7
Max concentration Product type 16/06/2014
Entry
283

5-Amino-6-Chloro-o- Cresol / 5-Amino-6-Chloro-o- Cresol HCl

3-amino-2-chlor- 6-methylphenol 3-amino-4-chloro- 6-methylphenol HCl

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
84540-50-1 / 80419-48-3
EC
283-144-9
Max concentration Product type 16/06/2014
Entry
284

2,2'-METHYLENEBIS 4-AMINOPHENOL HCL

Phenol, 2,2'- methylenebis[4- amino-], dihydrochloride

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
27311-52-0 / 63969-46-0
EC
440-850-3
Max concentration Product type 24/10/2021
Entry
285

2,6-Diaminopyridine

Pyridine-2,6- diyldiamine

(a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black…

CAS
141-86-6
EC
205-507-2
Product type 16/06/2014
Entry
286

CETRIMONIUM CHLORIDE (1) / STRARTRIMONIUM CHLORIDE (1)

C16-alkyltrimethylammonium chloride C18-alkyltrimethyammonium chloride

For purposes other than inhibiting the development of microorganisms in the product. The purpose has to be apparent from the presentation of the product.

CAS
112-02-7
EC
203-928-6
Max concentration Product type 22/06/2015
Entry
287

BEHENTRIMONIUM CHLORIDE (1)

C22-alkyltrimethylammonium chloride

For purposes other than inhibiting the development of microorganisms in the product. The purpose has to be apparent from the presentation of the product.

CAS
17301-53-0
EC
241-327-0
Max concentration Product type 22/06/2015

About this annex

Annex III covers substances that cosmetic products must not contain except under specific restrictions. These records often include warnings, conditions of use and concentration limits.

This section is especially useful for reviewing restricted substances, warning labels and product-type specific usage notes.