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Annex III Entry 271 16/06/2014

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone

Mixture of (1), (2) & (3) in dispersing agent (lignosulphate): (1) 9,10-Anthracenedione- 1,4-bis[(2- Hydroxyethyl)amino] (2) 9,10-Anthracenedione-1- [(2-Hydroxyethyl)amino]- 4-[(3- Hydroxypropyl)amino] (3) 9,10-anthracenedione- 1,4-bis[(3- hydroxypropyl)amino

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 2,0 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 2,0 %
Entry: 271

Chemical identity and properties

PubChem 2D chemical structure for CAS 4471-41-4
CAS 4471-41-4PubChem CID 20549

1,4-Bis((2-hydroxyethyl)amino)anthraquinone

IUPAC name
1,4-bis(2-hydroxyethylamino)anthracene-9,10-dione
Molecular formula
C18H18N2O4
Molecular weight
326.3 g/mol
Exact mass
326.12665706 Da
XLogP3
2.6
Topological polar surface area
98.7 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

1,4-Bis[(2-hydroxyethyl)amino]anthraquinone1,4-Bis[(2-hydroxyethyl)amino]-9,10-anthracenedione9,10-Anthracenedione, 1,4-bis((2-hydroxyethyl)amino)-1,4-Bis((2-hydroxyethyl)amino)-9,10-anthracenedione9,10-Anthracenedione, 1,4-bis[(2-hydroxyethyl)amino]-RefChem:416378Acetoquinone Blue BFdisperse blue 23
16 more reported names
Nyloquinone Blue NPCelliton Fast Blue BFSerisol Brilliant Blue 2BC.I. DISPERSE BLUE 231,4-BIS((2-HYDROXYETHYL)AMINO)ANTHRACENE-9,10-DIONEC.I. 61545O4U31606RT1,4-Bis[(2-hydroxyethyl)amino]anthra-9,10-quinoneNSC-128428Anthraquinone, 1,4-bis((2-hydroxyethyl)amino)-1,4-bis[(2-hydroxyethyl)amino]anthracene-9,10-dioneC.I.Disperse Blue 23EINECS 224-743-7NSC 128428BRN 2177770UNII-O4U31606RT
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67674-26-4
CAS 67674-26-4PubChem CID 105526

Disperse Blue 377

IUPAC name
1-(2-hydroxyethylamino)-4-(3-hydroxypropylamino)anthracene-9,10-dione
Molecular formula
C19H20N2O4
Molecular weight
340.4 g/mol
Exact mass
340.14230712 Da
XLogP3
2.9
Topological polar surface area
98.7 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

C.I. Disperse Blue 377EINECS 266-865-3UNII-N0436H2BUON0436H2BUOFUSION BLUELOWADENE BLUE 3779,10-Anthracenedione, 1-((2-hydroxyethyl)amino)-4-((3-hydroxypropyl)amino)-9,10-Anthracenedione, 1-[(2-hydroxyethyl)amino]-4-[(3-hydroxypropyl)amino]-
12 more reported names
1-(2-Hydroxyethylamino)-4-(3-hydroxypropylamino)-9,10-anthracenedioneC.I. 6150611-((2-Hydroxyethyl)amino)-4-((3-hydroxypropyl)amino)-9,10-anthracenedioneRefChem:135105DISPERSE BLUE 377 [INCI]266-865-3443-350-31-((2-Hydroxyethyl)amino)-4-((3-hydroxypropyl)amino)anthracene-9,10-dione1-[(2-HYDROXYETHYL)AMINO]-4-[(3-HYDROXYPROPYL)AMINO]-9,10-DIHYDROANTHRACENE-9,10-DIONE1-[(2-HYDROXYETHYL)AMINO]-4-[(3-HYDROXYPROPYL)AMINO]ANTHRACENE-9,10-DIONE1-((2-Hydroxyethyl)amino)-4-((3-hydroxypropyl)amino)anthraquinoneXWIBNOGPNKMAPE-UHFFFAOYSA-N
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67701-36-4
CAS 67701-36-4PubChem CID 105567

1,4-Bis((3-hydroxypropyl)amino)anthraquinone

IUPAC name
1,4-bis(3-hydroxypropylamino)anthracene-9,10-dione
Molecular formula
C20H22N2O4
Molecular weight
354.4 g/mol
Exact mass
354.15795719 Da
XLogP3
3.3
Topological polar surface area
98.7 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

J7DXZ79NTVEINECS 266-954-79,10-Anthracenedione, 1,4-bis[(3-hydroxypropyl)amino]-1,4-Bis((3-hydroxypropyl)amino)-9,10-anthracenedione9,10-Anthracenedione, 1,4-bis((3-hydroxypropyl)amino)-1,4-BIS[(3-HYDROXYPROPYL)AMINO]ANTHRAQUINONE1,4-Bis[(3-hydroxypropyl)amino]-9,10-anthracenedioneRefChem:196813
5 more reported names
266-954-71,4-Bis(3-hydroxypropylamino)-9,10-anthracenedioneUNII-J7DXZ79NTVLUYYUZYWBTWOFO-UHFFFAOYSA-N1,4-BIS[(3-HYDROXYPROPYL)AMINO]ANTHRACENE-9,10-DIONE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

2,0 %

Product type

Hair dye substance in non-oxidative hair dye products

INCI glossary name

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone

Chemical name

Mixture of (1), (2) & (3) in dispersing agent (lignosulphate): (1) 9,10-Anthracenedione- 1,4-bis[(2- Hydroxyethyl)amino] (2) 9,10-Anthracenedione-1- [(2-Hydroxyethyl)amino]- 4-[(3- Hydroxypropyl)amino] (3) 9,10-anthracenedione- 1,4-bis[(3- hydroxypropyl)amino

Chemical / IUPAC name

Mixture of (1), (2) & (3) in dispersing agent (lignosulphate): (1) 9,10-Anthracenedione- 1,4-bis[(2- Hydroxyethyl)amino] (2) 9,10-Anthracenedione-1- [(2-Hydroxyethyl)amino]- 4-[(3- Hydroxypropyl)amino] (3) 9,10-anthracenedione- 1,4-bis[(3- hydroxypropyl)amino

Regulatory information

Regulation

(EC) 2013/1197

See every entry this act set

Key data

CAS
(1) 4471-41-4/(2) 67674-26-4/(3) 67701-36-4
EC
(1) 224-743-7/(2) 266-865-3/(3) 266-954-7
Annex
III
Entry number
271

Inventory links for Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone

Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9
Annex III 204
Shared product type

DIHYDROXYINDOLINE

CAS: 29539-03-5 - 138937-28-7
EC: - - 421-170-6

What Annex III means for Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 2,0 %
  • Confirm product type compatibility: Hair dye substance in non-oxidative hair dye products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS (1) 4471-41-4/(2) 67674-26-4/(3) 67701-36-4 is the unique numerical identifier assigned to Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 2,0 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone

This page summarizes one Annex III record for Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Disperse Blue 377 is a mixture of three dyes:(1) 1,4-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone/(2) 1-[(2-hydroxyethyl)amino]-4-[(3- hydroxypropyl)amino]anthra- 9,10-quinone/(3) 1,4-bis[(3- hydroxypropyl)amino]anthra- 9,10-quinone, but confirm any final regulatory decision against the current official annex wording and source files.

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