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Annex III Entry 282 16/06/2014

HC Blue 16

1-Propanaminium, 3-[[9,10-dihydro- 4-(methylamino)- 9,10-dioxo-1- anthracenyl] amino]-N,N- dimethyl-N- propyl-, bromide

HC Blue 16 is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 3,0 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 3,0 %
Entry: 282

Record details

Maximum concentration

3,0 %

Product type

Hair dye substance in non-oxidative hair dye products

Other restrictions

— Do not use with nitrosating agents
— Maximum nitrosamine content: 50 μg/kg
— Keep in nitrite-free containers

INCI glossary name

HC Blue 16

Chemical name

1-Propanaminium, 3-[[9,10-dihydro- 4-(methylamino)- 9,10-dioxo-1- anthracenyl] amino]-N,N- dimethyl-N- propyl-, bromide

Chemical / IUPAC name

1-Propanaminium, 3-[[9,10-dihydro- 4-(methylamino)- 9,10-dioxo-1- anthracenyl] amino]-N,N- dimethyl-N- propyl-, bromide

Regulatory information

Regulation

(EC) 2013/1197

Key data

CAS
502453-61-4
EC
481-170-7
Annex
III
Entry number
282

Inventory links for HC Blue 16

Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9
Annex III 204
Shared product type

DIHYDROXYINDOLINE

CAS: 29539-03-5 - 138937-28-7
EC: - - 421-170-6

What Annex III means for HC Blue 16

HC Blue 16 is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 3,0 %
  • Confirm product type compatibility: Hair dye substance in non-oxidative hair dye products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HC Blue 16 is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 502453-61-4 is the unique numerical identifier assigned to HC Blue 16 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 3,0 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record HC Blue 16

This page summarizes one Annex III record for HC Blue 16 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HC Blue 16, but confirm any final regulatory decision against the current official annex wording and source files.

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