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Annex III Entry 261 09/09/2013

HC Yellow No 13

N-(2-Hydroxyethyl)-2-nitro-4- trifluormethyl-aniline

HC Yellow No 13 is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 261

Chemical identity and properties

PubChem 2D chemical structure for CAS 10442-83-8
CAS 10442-83-8PubChem CID 2799157

HC Yellow No. 13

IUPAC name
2-[2-nitro-4-(trifluoromethyl)anilino]ethanol
Molecular formula
C9H9F3N2O3
Molecular weight
250.17 g/mol
Exact mass
250.05652664 Da
XLogP3
2.0
Topological polar surface area
78.1 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

2-((2-Nitro-4-(trifluoromethyl)phenyl)amino)ethanolHC Yellow 132-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethanol4-(2-Hydroxyethylamino)-3-nitrobenzotrifluoride0448DT2KKSEthanol, 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)-Ethanol, 2-(alpha,alpha,alpha-trifluoro-2-nitro-p-toluidino)-ETHANOL, 2-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-2-NITRO-P-TOLUIDINO)-
15 more reported names
2-[[2-Nitro-4-(trifluoromethyl)phenyl]amino]ethanol2-[{2-Nitro-4-(trifluoromethyl)phenyl}amino]ethanolEthanol, 2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-RefChem:783439HC YELLOW NO. 13 [INCI]N-(2-Hydroxyethyl)-2-nitro-5-(trifluoromethyl)anilineUNII-0448DT2KKS4-(2-HydroMaybridge1_001425HMS545I17BS-26053CS-02083262-[2-nitro-4-(trifluoromethyl)anilino]ethan-1-ol2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethan-1-ol2-{[2-nitro-4-(trifluoromethyl)phenyl]-amino}-ethanol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:747841

HC Yellow 13

2-[2-nitro-4-(trifluoromethyl)anilino]ethanol

Formula
C9H9F3N2O3
Average mass
250.176 g/mol
Monoisotopic mass
250.05653 Da
Formal charge
0
  • organic molecular entity — is a (CHEBI:50860)
  • organic molecular entity — is a (CHEBI:50860)
Additional curated names
2-[2-nitro-4-(trifluoromethyl)anilino]ethanol
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2026-06-03. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match2799157

Attributed physical-property, hazard, environmental and use annotations.

  • GHS Hazard Statements: H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 36 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 100% (6 of 6) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 6 of 6 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 6 reports by companies from 1 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 6 of 6 reports by companies.; There are 0 notifications provided by 0 of 6 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Product type

After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,5% For (a) and (b): - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers

Warnings

To be printed on the label:
Hair colorants can cause severe allergic reactions

INCI glossary name

HC Yellow No 13

Chemical name

N-(2-Hydroxyethyl)-2-nitro-4- trifluormethyl-aniline

Chemical / IUPAC name

N-(2-Hydroxyethyl)-2-nitro-4- trifluormethyl-aniline

Regulatory information

Regulation

(EU) 2013/658

See every entry this act set

Key data

CAS
10442-83-8
EC
443-760-2
Annex
III
Entry number
261

Inventory links for HC Yellow No 13

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 260
Nearby record in the same annex

HC Yellow No 7

CAS: 104226-21-3
EC: 146-420-6
Annex III 262
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BASIC YELLOW 57

CAS: 68391-31-1
EC: 269-943-5
Annex III 259
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HC Yellow No 9

CAS: 86419-69-4
EC: 415-480-1
Annex III 263
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Disperse Black 9

CAS: 20721-50-0
EC: 243-98-5
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Nearby record in the same annex

HC Red No 1

CAS: 2784-89-6
EC: 220-494-3
Annex III 264
Nearby record in the same annex

HC Blue No 14

CAS: 99788-75-7
EC: 421-470-7
Annex III 257
Nearby record in the same annex

LAURETH-9

CAS: 3055-99-0
EC: 221-284-4
Annex III 256
Nearby record in the same annex

HC Orange No 1

CAS: 54381-08-7
EC: 259-132-4
Annex III 266
Nearby record in the same annex

HC RED No 3

CAS: 2871-01-4
EC: 220-701-7
Annex III 255
Nearby record in the same annex

HC Yellow No 2

CAS: 4926-55-0
EC: 225-555-8
Annex III 267
Nearby record in the same annex

BASIC RED 76

CAS: 68391-30-0
EC: 269-941-4

What Annex III means for HC Yellow No 13

HC Yellow No 13 is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,5% For (a) and (b): - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HC Yellow No 13 is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 10442-83-8 is the unique numerical identifier assigned to HC Yellow No 13 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record HC Yellow No 13

This page summarizes one Annex III record for HC Yellow No 13 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HC Yellow No 13, but confirm any final regulatory decision against the current official annex wording and source files.

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