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Annex III Entry 25 17/10/2010

ZINC PHENOLSULFONATE

Zinc 4-hydroxybenzene sulphonate

ZINC PHENOLSULFONATE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 6% (as % of anhydrous substance).

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 6% (as % of anhydrous substance)
Entry: 25

Chemical identity and properties

PubChem 2D chemical structure for CAS 127-82-2
CAS 127-82-2PubChem CID 31391

Zinc Phenolsulfonate

Zinc phenolsulfonate appears as a colorless to white crystalline solid which turns pink on exposure to air. The primary is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is soluble in water. It is used as an insecticide and in medicine. — CAMEO Chemicals

IUPAC name
zinc bis(4-hydroxybenzenesulfonate)
Molecular formula
C12H10O8S2Zn
Molecular weight
411.7 g/mol
Exact mass
409.910851 Da
Topological polar surface area
172.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
8
Covalent units
3
Defined stereocentres
0

Also known as

Benzenesulfonic acid, 4-hydroxy-, zinc salt (2:1)HSDB 2551EINECS 204-867-8Zinc bis(4-hydroxybenzenesulphonate)UNII-4O71YT5YB5EPA Pesticide Chemical Code 089002zinc phenolsulphonate4O71YT5YB5
16 more reported names
Zinc phenolsulfonate [NF]ZINC P-PHENOLSULPHONATEZINC PARAPHENOLSULFONATEZINC PARAPHENOLSULPHONATEZINC PHENOLSULFONATE [HSDB]ZINC PHENOLSULFONATE [VANDF]ZINC PHENOLSULFONATE [MART.]ZINC PHENOLSULFONATE [WHO-DD]4-HYDROXYBENZENESULFONIC ACID (2:1), ZINC SALTZINC PHENOLSULFONATE (MART.)((4-hydroxybenzenesulfonyl)oxy)zincio 4-hydroxybenzene-1-sulfonate[(4-hydroxybenzenesulfonyl)oxy]zincio 4-hydroxybenzene-1-sulfonatezinc phenolsulfateZinc pphenolsulfonateCaswell No 921AZinc phenolsulfic acid
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External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31391

Attributed physical-property, hazard, environmental and use annotations.

  • Boiling Point: 248 °F at 760 mmHg (decomposes) (USCG, 1999) Source: CAMEO Chemicals
  • Physical Description: Zinc phenolsulfonate appears as a colorless to white crystalline solid which turns pink on exposure to air. The primary is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is soluble in water. It is used as an insecticide and in medicine. Source: CAMEO Chemicals
  • Physical Description: Octahydrate: Odorless solid; Effloresces in dry air; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • First Aid: INHALATION: move to fresh air.; INGESTION: if large amount has been swallowed, induce vomiting, followed by prompt and complete gastric lavage, cathartics, and demulcents.; EYES or SKIN: flush with water. (USCG, 1999) Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 46.8% (36 of 77) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (53.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (51.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (51.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (51.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 77 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 36 of 77 reports by companies.; There are 4 notifications provided by 41 of 77 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Health Effects: Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) Source: Toxin and Toxin Target Database (T3DB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

6% (as % of anhydrous substance)

Product type

Deodorants, antiperspirants and astringent lotions

Warnings

Avoid contact with eyes

INCI glossary name

ZINC PHENOLSULFONATE

Chemical name

Zinc 4-hydroxybenzene sulphonate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
127-82-2
EC
204-867-8
Annex
III
Entry number
25

Inventory links for ZINC PHENOLSULFONATE

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 22
Nearby record in the same annex

RESORCINOL

CAS: 108-46-3
EC: 203-585-2
Annex III 21
Nearby record in the same annex

QUININE

CAS: 130-95-0
EC: 205-003-2
Annex III 30
Nearby record in the same annex

Calcium fluoride

CAS: 7789-75-5
EC: 232-188-7
Annex III 18
Nearby record in the same annex

NITROMETHANE

CAS: 75-52-5
EC: 200-876-6
Annex III 31
Nearby record in the same annex

Sodium fluoride

CAS: 7681-49-4
EC: 231-667-8
Annex III 17
Nearby record in the same annex

SODIUM NITRITE

CAS: 7632-00-0
EC: 231-555-9

What Annex III means for ZINC PHENOLSULFONATE

ZINC PHENOLSULFONATE is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 6% (as % of anhydrous substance)
  • Confirm product type compatibility: Deodorants, antiperspirants and astringent lotions
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

ZINC PHENOLSULFONATE is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 127-82-2 is the unique numerical identifier assigned to ZINC PHENOLSULFONATE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 6% (as % of anhydrous substance) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record ZINC PHENOLSULFONATE

This page summarizes one Annex III record for ZINC PHENOLSULFONATE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for ZINC PHENOLSULFONATE, but confirm any final regulatory decision against the current official annex wording and source files.

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