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Annex III Entry 280 16/06/2014

Picramic Acid and Sodium Picramate

2-Amino-4,6-dinitrophenol and 2- amino-4,6-dinitrophenol, sodium salt

Picramic Acid and Sodium Picramate is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 0.6 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (b) 0.6 %
Entry: 280

Chemical identity and properties

PubChem 2D chemical structure for CAS 831-52-7
CAS 831-52-7PubChem CID 5362461

Sodium Picramate

Sodium picramate, wetted with not less than 20% water appears as a slurry of dark red crystals. Highly explosive. Burns vigorously when dry. May explode if in large quantities. Burns when wet, but difficult to ignite. Produces toxic oxides of nitrogen during combustion. — CAMEO Chemicals

IUPAC name
sodium 2-amino-4,6-dinitrophenolate
Molecular formula
C6H4N3NaO5
Molecular weight
221.10 g/mol
Exact mass
221.00486452 Da
Topological polar surface area
141.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

Phenol, 2-amino-4,6-dinitro-, monosodium salt2-Amino-4,6-dinitrophenol monosodium saltEINECS 212-603-8UNII-4988SZV57R2-Amino-4,6-dinitrophenol, sodium salt4988SZV57RPhenol, 2-amino-4,6-dinitro-, sodium saltEC 212-603-8
16 more reported names
Phenol, 2-amino-4,6-dinitro-, sodium salt (1:1)SODIUM PICRAMATE, (WET, WITH >= 20% WATER)SODIUM PICRAMATE, [WET, WITH >= 20% WATER]SODIUM PICRAMINATERefChem:184081SODIUM PICRAMATE [INCI]PICRAMIC ACID, SODIUM DERIV.SODIUM PICRAMATE, WETTED WITH NOT LESS THAN 20% WATER212-603-8Picramic Acid Sodium SaltSodium 2-amino-4,6-dinitrophenoxidesodium;2-amino-4,6-dinitrophenolateSodium, (2-amino-4,6-dinitrophenoxy)-sodium 2-amino-4,6-dinitrophenolUN0235UN1349
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 96-91-3
CAS 96-91-3PubChem CID 4921319

Picramic Acid

2-amino-4,6-dinitrophenol, wetted with not less than 20% water appears as dark red needles or prisms. Red crystals. Water insoluble. Explosive in the dry state but desensitized by wetting. Easily ignited and once ignited burn readily. — CAMEO Chemicals

IUPAC name
2-amino-4,6-dinitrophenol
Molecular formula
C6H5N3O5
Molecular weight
199.12 g/mol
Exact mass
199.02292027 Da
XLogP3
0.9
Topological polar surface area
138.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

Fourrine 4RFourrine 93Furro 4RAcide picramiqueOxidation Base 21Zoba 4R2,4-Dinitro-6-aminophenolC.I. Oxidation Base 21
16 more reported names
CI Oxidation Base 211-Amino-2-hydroxy-3,5-dinitrobenzene5VDQ7GK8L3CI 76540NSC-36939C.I. 765401-AMINO-3,5-DINITRO-2-HYDROXYBENZENERefChem:174178202-544-66-Amino-2,4-dinitrophenolPhenol, 2-amino-4,6-dinitro-4,6-DINITRO-2-AMINOPHENOLNSC 36939Acide picramique [French]CCRIS 1003HSDB 4319
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(b) 0.6 %

Product type

Hair dye substance in oxidative hair dye products Hair dye substance in non-oxidative hair dye products

Other restrictions

(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,6 %

Warnings

(a) To be printed on the label: The mixing ratio.
“ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”

INCI glossary name

Picramic Acid and Sodium Picramate

Chemical name

2-Amino-4,6-dinitrophenol and 2- amino-4,6-dinitrophenol, sodium salt

Chemical / IUPAC name

2-Amino-4,6-dinitrophenol and 2- amino-4,6-dinitrophenol, sodium salt

Regulatory information

Regulation

(EC) 2013/1197

See every entry this act set

Key data

CAS
96-91-3 / 831-52-7
EC
202-544-6 / 212-603-8
Annex
III
Entry number
280

Inventory links for Picramic Acid and Sodium Picramate

Inventory Shared CAS number
Ref 36562

PICRAMIC ACID

CAS: 96-91-3
EC: 202-544-6
Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9

What Annex III means for Picramic Acid and Sodium Picramate

Picramic Acid and Sodium Picramate is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (b) 0.6 %
  • Confirm product type compatibility: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

Picramic Acid and Sodium Picramate is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 96-91-3 / 831-52-7 is the unique numerical identifier assigned to Picramic Acid and Sodium Picramate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (b) 0.6 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record Picramic Acid and Sodium Picramate

This page summarizes one Annex III record for Picramic Acid and Sodium Picramate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Picramic Acid and Sodium Picramate, but confirm any final regulatory decision against the current official annex wording and source files.

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