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Annex III Entry 257 16/06/2015

LAURETH-9

Laureth-9

LAURETH-9 is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (a) 3,0 % (b) 4,0 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (a) 3,0 % (b) 4,0 %
Entry: 257

Chemical identity and properties

PubChem 2D chemical structure for CAS 3055-99-0
CAS 3055-99-0PubChem CID 656641

Nonaethylene Glycol Monododecyl Ether

Polidocanol is a hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group. It has a role as a nonionic surfactant, a hepatotoxic agent and a sclerotherapy agent. It is functionally related to a nonaethylene glycol. — ChEBI

IUPAC name
2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Molecular formula
C30H62O10
Molecular weight
582.8 g/mol
Exact mass
582.43429817 Da
XLogP3
3.9
Topological polar surface area
103.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
10
Covalent units
1
Defined stereocentres
0

Also known as

PolidocanolAscleraAethoxy-sklerolnonaethylene glycol monolauryl etherVARITHENAPEG-9 lauryl etherMacrogol 9 lauryl etherdodecyl nonaoxyethylene ether
16 more reported names
CHEBI:46859C12-E9Dodecylnonaoxyethylene glycol monoetherBrij30LauromacrogolsPolidocanolsLaurethsLaureth 1Laureth 72-(2-(2-(2-(2-(2-(2-(2-(2-dodecoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanolRefChem:8546NIKKOL BL-9EXPolyoxyethylenedodecyl EthersPolyoxyethylene Lauryl EthersMARLIPAL 24/90Ether, Polyoxyethylene Lauryl
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(a) 3,0 % (b) 4,0 %

Product type

Leave-on products Rinse-off products

INCI glossary name

LAURETH-9

Chemical name

Laureth-9

Chemical / IUPAC name

Polidocanol

Regulatory information

Regulation

(EU) 2013/483

See every entry this act set

Key data

CAS
3055-99-0
EC
221-284-4
Annex
III
Entry number
257

Inventory links for LAURETH-9

Inventory Shared INCI name
Ref 34930

LAURETH-9

CAS: 3055-99-0 / 9002-92-0 / 68439-50-9
EC: 221-284-4 / 500-002-6 / 500-213-3
Annex III 100
Shared product type

TRICLOCARBAN

CAS: 101-20-2
EC: 202-924-1

What Annex III means for LAURETH-9

LAURETH-9 is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (a) 3,0 % (b) 4,0 %
  • Confirm product type compatibility: (a) Leave-on products (b) Rinse-off products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

LAURETH-9 is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 3055-99-0 is the unique numerical identifier assigned to LAURETH-9 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (a) 3,0 % (b) 4,0 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record LAURETH-9

This page summarizes one Annex III record for LAURETH-9 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for LAURETH-9, but confirm any final regulatory decision against the current official annex wording and source files.

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