Sodium monofluorophosphate
Sodium monofluorophosphate is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0.15% calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0.15%.
Chemical identity and properties
Sodium Monofluorophosphate
Sodium fluorophosphate, commonly abbreviated MFP, is an inorganic compound with the chemical formula Na2PO3F. Typical for a salt, MFP is odourless, colourless, and water-soluble. This salt is an ingredient in toothpastes. It has a role as an antibacterial agent. It is an inorganic phosphate and an inorganic sodium salt. — ChEBI
- IUPAC name
- disodium;fluoro-dioxido-oxo-lambda5-phosphane
- Molecular formula
- FNa2O3P
- Molecular weight
- 143.950 g/mol
- Exact mass
- 143.93644758 Da
- Topological polar surface area
- 63.2 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:86431
- ChEMBL:CHEMBL1908359
- EPA DTXSID:DTXSID70872554
- PubMed:1234
Evidence from additional scientific databases
EMBL-EBI ChEBI
sodium fluorophosphate
Sodium fluorophosphate, commonly abbreviated MFP, is an inorganic compound with the chemical formula Na2PO3F. Typical for a salt, MFP is odourless, colourless, and water-soluble. This salt is an ingredient in toothpastes.
- Formula
- FO3P.2Na
- Average mass
- 143.949 g/mol
- Monoisotopic mass
- 143.93645 Da
- Formal charge
- 0
- inorganic sodium salt — is a (CHEBI:38702)
- inorganic phosphate — is a (CHEBI:24838)
- antibacterial agent — has role (CHEBI:33282)
- antibacterial agent — has role (CHEBI:33282)
- inorganic sodium salt — is a (CHEBI:38702)
- inorganic phosphate — is a (CHEBI:24838)
Additional curated names
Cross-references from this source
- CAS: 10163-15-2 — KEGG DRUG
- CAS: 10163-15-2 — ChemIDplus
- REGISTRY_NUMBER: 11335196 — Reaxys
- MANUAL_X_REF: D05864 — KEGG DRUG
- MANUAL_X_REF: Sodium_monofluorophosphate — Wikipedia
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-07-24. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: White powder; [Pfaltz and Bauer MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Note: This chemical does not meet GHS hazard criteria for 1.4% (1 of 72) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (91.7%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P270, P280, P301+P317, P302+P352, P321, P330, P332+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 72 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 72 reports by companies.; There are 4 notifications provided by 71 of 72 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
0.15% calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0.15%
Product type
Warnings
Contains sodium monofluorophosphate
For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use only") the following labelling is obligatory:
"Children of 6 years and younger: use a pea-sized amount for supervised brushing to minimise swallowing. In case of intake of fluoride from other sources consult a dentist or doctor."
Chemical name
Sodium monofluorophosphate
Chemical / IUPAC name
Disodium fluorophosphate
Regulatory information
SCCS opinions
- Opinion concerning the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 years
- Opinion on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 Years
- Clarification on the Opinions SCCNFP/0653/03 and SCCP/0882/05 on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 Years
Identified ingredients
Key data
Inventory links for Sodium monofluorophosphate
SODIUM MONOFLUOROPHOSPHATE
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What Annex III means for Sodium monofluorophosphate
Sodium monofluorophosphate is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: 0.15% calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0.15%
- Confirm product type compatibility: Oral products
- Include required warning statement on product label.
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Sodium monofluorophosphate
This page summarizes one Annex III record for Sodium monofluorophosphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Sodium monofluorophosphate, but confirm any final regulatory decision against the current official annex wording and source files.
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