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Annex III Entry 256 09/09/2013

HC Orange No 1

4-[(2-Nitrophenyl)amino]phenol

HC Orange No 1 is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 1.0%.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 1.0%
Entry: 256

Chemical identity and properties

PubChem 2D chemical structure for CAS 54381-08-7
CAS 54381-08-7PubChem CID 3846708

HC Orange No. 1

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that HC Orange No. 1 is safe for use in hair dye formulations at concentrations up to 3.0%. — Cosmetic Ingredient Review (CIR)

IUPAC name
4-(2-nitroanilino)phenol
Molecular formula
C12H10N2O3
Molecular weight
230.22 g/mol
Exact mass
230.06914219 Da
XLogP3
3.3
Topological polar surface area
78.1 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

4-((2-Nitrophenyl)amino)phenolHC Orange 1Phenol, 4-[(2-nitrophenyl)amino]-2-Nitro-4'-hydroxydiphenylamine4-[(2-nitrophenyl)amino]phenolPhenol, 4-((2-nitrophenyl)amino)-COLOREX HCO1EINECS 259-132-4
16 more reported names
Z92U49184U4'-HYDROXY-2-NITRODIPHENYLAMINEUNII-Z92U49184UN-(4-HYDROXYPHENYL)-2-NITROANILINERefChem:145369HC ORANGE NO. 1 [INCI]259-132-44-(2-nitroanilino)benzenolHC orange No 1p-((o-Nitrophenyl)amino)phenol4-[(2-Nitrophenyl)amino]-phenol4-hydroxy-2'-nitrodiphenylamineHSDSBIUUVWRHTM-UHFFFAOYSA-NREGID_for_CID_3846708MS-3693DB-052551
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

1.0%

Product type

Hair dye substance in non-oxidative hair dye products

INCI glossary name

HC Orange No 1

Chemical name

4-[(2-Nitrophenyl)amino]phenol

Chemical / IUPAC name

4-[(2-Nitrophenyl)amino]phenol

Regulatory information

Regulation

(EU) 2013/658

See every entry this act set

Key data

CAS
54381-08-7
EC
259-132-4
Annex
III
Entry number
256

Inventory links for HC Orange No 1

Inventory Restriction reference
Ref 34201

HC ORANGE NO. 1

CAS: 54381-08-7
EC: 259-132-4
Annex III 190
Shared product type

ACID BLUE 9

CAS: 3844-45-9 - 2650-18-2 - 68921-42-6
EC: 223-339-8 - 220-168-0 - 272-939-6
Annex III 191
Shared product type

CURRY RED

CAS: 25956-17-6
EC: 247-368-0
Annex III 192
Shared product type

ACID RED 18

CAS: 2611-82-7 - 12227-64-4
EC: 220-036-2 - 235-438-3
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8
Annex III 195
Shared product type

ACID BLUE 62

CAS: 4368-56-3
EC: 224-460-9
Annex III 204
Shared product type

DIHYDROXYINDOLINE

CAS: 29539-03-5 - 138937-28-7
EC: - - 421-170-6

What Annex III means for HC Orange No 1

HC Orange No 1 is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 1.0%
  • Confirm product type compatibility: Hair day substance in non-oxidative hair dye products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HC Orange No 1 is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 54381-08-7 is the unique numerical identifier assigned to HC Orange No 1 by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 1.0% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record HC Orange No 1

This page summarizes one Annex III record for HC Orange No 1 from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HC Orange No 1, but confirm any final regulatory decision against the current official annex wording and source files.

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