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Annex III Entry 374 04/04/2024

Daidzein

Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Daidzein is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0,02 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 0,02 %
Entry: 374

Record details

Maximum concentration

0,02 %

Other restrictions

From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.

INCI glossary name

Daidzein

Chemical name

Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Regulatory information

Regulation

(EU) 2024/996

SCCS opinions

Identified ingredients

Key data

CAS
486-66-8
EC
207-635-4
Annex
III
Entry number
374

Inventory links for Daidzein

Inventory Identified ingredient
Ref 91424

DAIDZEIN

CAS: 486-66-8
EC: 207-635-4

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 373
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Alpha-Arbutin

CAS: 84380-01-8
EC: 617-561-8
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Arbutin

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EC: 207-850-3
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Geranyl Acetate

CAS: 105-87-3
EC: 203-341-5
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Silver

CAS: 7440-22-4
EC: 231-131-3
Annex III 380
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Hexyl Salicylate

CAS: 6259-76-3
EC: 228-408-6

What Annex III means for Daidzein

Daidzein is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 0,02 %
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

Daidzein is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 486-66-8 is the unique numerical identifier assigned to Daidzein by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0,02 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record Daidzein

This page summarizes one Annex III record for Daidzein from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Daidzein, but confirm any final regulatory decision against the current official annex wording and source files.

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