Daidzein
Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
Daidzein is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0,02 %.
Chemical identity and properties
Daidzein
Daidzein is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'. It has a role as an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor, an antineoplastic agent, an EC 3.2.1.20 (alpha-glucosidase) inhibitor, a plant metabolite and a phytoestrogen. It is a conjugate acid of a daidzein(1-). — ChEBI
- IUPAC name
- 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
- Molecular formula
- C15H10O4
- Molecular weight
- 254.24 g/mol
- Exact mass
- 254.05790880 Da
- XLogP3
- 2.5
- Topological polar surface area
- 66.8 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:28197
- ChEMBL:CHEMBL8145
- EPA DTXSID:DTXSID9022310
- PubMed:24468190
- PubMed:23124344
- PubMed:23115971
- PubMed:23110148
- PubMed:23042672
- PubMed:23010479
- PubMed:22997529
- PubMed:22980879
- PubMed:22962536
- PubMed:22953905
- PubMed:22953902
- PubMed:22953831
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
0,02 %
Other restrictions
From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.
INCI glossary name
Daidzein
Chemical name
Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
Regulatory information
SCCS opinions
- Scientific opinion on genistein and daidzein preliminary version of 12 January 2022, final version of 16 September 2022, corrigendum of 11 October 2022 SCCS/1641/22
Identified ingredients
Key data
Inventory links for Daidzein
Related records for Daidzein
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
Retinol; Retinyl Acetate; Retinyl Palmitate
Pinene
Phenol, 2-methoxy- 4-(2-propenyl)-, acetate
What Annex III means for Daidzein
Daidzein is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: 0,02 %
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Daidzein
This page summarizes one Annex III record for Daidzein from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Daidzein, but confirm any final regulatory decision against the current official annex wording and source files.
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