Hydroxyapatite (nano)
Hydroxyapatite
Hydroxyapatite (nano) is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (a) 10 % (b) 0,465 %.
Chemical identity and properties
Hydroxylapatite (Ca5(OH)(PO4)3)
Hydroxylapatite is a mineral with formula of Ca5(PO4)3OH. The corresponding IMA (International Mineralogical Association) number is IMA2010 s.p.. The IMA symbol is Hap. — RRUFF Project
- IUPAC name
- pentacalcium;hydroxide;triphosphate
- Molecular formula
- Ca5HO13P3
- Molecular weight
- 502.3 g/mol
- Exact mass
- 501.675955 Da
- Topological polar surface area
- 260.0 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 13
- Covalent units
- 9
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL2218916
- EPA DTXSID:DTXSID50872537
- PubMed:22939914
- PubMed:21705322
- PubMed:11518271
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Hexagonal needles arranged in rosettes Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Finely divided, crystalline, nonstoichiometric material. Source: Hazardous Substances Data Bank (HSDB)
- Density: Density: 3.1 to 3.2 /Apatite/ Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Solid; [Merck Index] White suspension; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Practically insol in water, even when freshly prepared Source: Hazardous Substances Data Bank (HSDB)
- Note: This chemical does not meet GHS hazard criteria for 97.8% (362 of 370) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 362 of 370 companies (only 2.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 370 reports by companies from 5 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 362 of 370 reports by companies.; There are 3 notifications provided by 8 of 370 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Note: This chemical does not meet GHS hazard criteria for 94% (188 of 200) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 188 of 200 companies (only 6% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 200 reports by companies from 6 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 188 of 200 reports by companies.; There are 3 notifications provided by 12 of 200 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Consumer Uses: Not Known or Reasonably Ascertainable; Filler Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Processing aids not otherwise specified; Filler; Soil amendments (fertilizers); Stabilizing agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Naturally occurring mineral in phosphate rocks and in bone; [Merck Index] Used in fertilizers, laser crystals, ion-exchange chromatography (especially for proteins), artificial bone and teeth, and calcium/phosphorus supplement; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Source of phosphorus & phosphoric acid; mfr of fertilizers; laser crystals /Apatite/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: USED IN DENTURE & ORTHOPEDIC MATERIALS; USED IN ION-EXCHANGE CHROMATOGRAPHY ESPECIALLY FOR PROTEINS Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
- Uses: Prosthetic aid (artificial bone and teeth). Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for HYDROXYAPATITE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Plastics -> Typical concentration range in plastic materials -> 5% Source: NORMAN Suspect List Exchange
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
(a) 10 % (b) 0,465 %
Product type
Other restrictions
For (a) and (b): Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation.
Only nanomaterials having the following characteristics are allowed:
— [composed of] rod-shaped particles of which at least 95,8 % (in particle number) have an aspect ratio less than 3, and the remaining 4,2 % have an aspect ratio not exceeding 4,9;
— the particles are not coated or surface modified
INCI glossary name
Hydroxyapatite (nano)
Chemical name
Hydroxyapatite
Regulatory information
SCCS opinions
Identified ingredients
Key data
Inventory links for Hydroxyapatite (nano)
Related records for Hydroxyapatite (nano)
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
POTASSIUM CHLORATE / SODIUM CHLORATE
Pinene
Phenol, 2-methoxy- 4-(2-propenyl)-, acetate
What Annex III means for Hydroxyapatite (nano)
Hydroxyapatite (nano) is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: (a) 10 % (b) 0,465 %
- Confirm product type compatibility: (a) Toothpaste (b) Mouthwash
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Hydroxyapatite (nano)
This page summarizes one Annex III record for Hydroxyapatite (nano) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Hydroxyapatite (nano), but confirm any final regulatory decision against the current official annex wording and source files.
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