Genistein
Genisteol; 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
Genistein is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0,007 %.
Chemical identity and properties
Genistein
Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as a geroprotector, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a plant metabolite, a phytoestrogen and a human urinary metabolite. It is a conjugate acid of a genistein(1-). — ChEBI
- IUPAC name
- 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
- Molecular formula
- C15H10O5
- Molecular weight
- 270.24 g/mol
- Exact mass
- 270.05282342 Da
- XLogP3
- 2.7
- Topological polar surface area
- 87.0 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Maximum concentration
0,007 %
Other restrictions
From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.
INCI glossary name
Genistein
Chemical name
Genisteol; 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
Regulatory information
SCCS opinions
- Scientific opinion on genistein and daidzein preliminary version of 12 January 2022, final version of 16 September 2022, corrigendum of 11 October 2022 SCCS/1641/22
Identified ingredients
Key data
Inventory links for Genistein
Related records for Genistein
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
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What Annex III means for Genistein
Genistein is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Ensure formulation concentration does not exceed: 0,007 %
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Genistein
This page summarizes one Annex III record for Genistein from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Genistein, but confirm any final regulatory decision against the current official annex wording and source files.
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