EU cosmetic ingredients, restrictions and safety

Annex III Entry 373 04/04/2024

Genistein

Genisteol; 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Genistein is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 0,007 %.

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Restricted substance— Annex III, EU Regulation 1223/2009

Max conc.: 0,007 %

Entry: 373

Record details

Maximum concentration

0,007 %

Other restrictions

From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.

INCI glossary name

Genistein

Chemical name

Genisteol; 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Regulatory information

Regulation

(EU) 2024/996

SCCS opinions

Scientific opinion on genistein and daidzein preliminary version of 12 January 2022, final version of 16 September 2022, corrigendum of 11 October 2022 SCCS/1641/22

Identified ingredients

GENISTEIN

Key data

CAS

EC

Annex

Entry number

373

Inventory links for Genistein

Inventory Identified ingredient

Ref 85188

GENISTEIN

CAS: 446-72-0

EC: 207-174-9

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 372

Nearby record in the same annex

Hydroxyapatite (nano)

CAS: 1306-06-5

EC: 215-145-7

Annex III 374

Nearby record in the same annex

Daidzein

CAS: 486-66-8

EC: 207-635-4

Annex III 371

Nearby record in the same annex

Pinene

CAS: 80-56-8/ 7785-70-8/ 127-91-3/ 18172-67-3

EC: 201-291-9/ 232-087-8/ 204-872-5/ 242-060-2

Annex III 375

Nearby record in the same annex

Kojic Acid

CAS: 501-30-4

EC: 207-922-4

Annex III 370

Nearby record in the same annex

Isoeugenyl Acetate

CAS: 93-29-8

EC: 202-236-1

Annex III 376

Nearby record in the same annex

Retinol; Retinyl Acetate; Retinyl Palmitate

CAS: 11103-57-4/ 68-26-8; 127-47-9; 79-81-2

EC: 234-328-2/ 200-683-7; 204-844-2; 201-228-5

Annex III 369

Nearby record in the same annex

Geranyl Acetate

CAS: 105-87-3

EC: 203-341-5

Annex III 377

Nearby record in the same annex

Alpha-Arbutin

CAS: 84380-01-8

EC: 617-561-8

Annex III 368

Nearby record in the same annex

Phenol, 2-methoxy- 4-(2-propenyl)-, acetate

CAS: 93-28-7

EC: 202-235-6

Annex III 378

Nearby record in the same annex

Arbutin

CAS: 497-76-7

EC: 207-850-3

Annex III 367

Nearby record in the same annex

Santalum Album Oil

CAS: 8006-87-9/ 84787-70-2

EC: 8006-87-9/ 84787-70-2

Annex III 379

Nearby record in the same annex

Silver

CAS: 7440-22-4

EC: 231-131-3

What Annex III means for Genistein

Genistein is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Ensure formulation concentration does not exceed: 0,007 %
Document conditions of use in the Product Information File (PIF).

Frequently asked questions

Genistein is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 446-72-0 is the unique numerical identifier assigned to Genistein by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0,007 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex III record Genistein

This page summarizes one Annex III record for Genistein from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Genistein, but confirm any final regulatory decision against the current official annex wording and source files.

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