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Annex II Entry 454 CMR17/12/2010

Cobalt sulphate

Cobalt sulphate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 454
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 10124-43-3
CAS 10124-43-3PubChem CID 24965

Cobalt Sulfate

Cobalt(2+) sulfate is a compound of cobalt and sulfate in which the ratio of cobalt (+2 oxidation state) to sulfate is 1:1. It contains a cobalt(2+). — ChEBI

IUPAC name
cobalt(2+) sulfate
Molecular formula
CoO4S
Molecular weight
155.00 g/mol
Exact mass
154.884923 Da
Topological polar surface area
88.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0

Also known as

Cobaltous sulfateCobalt(II) sulfateCobalt BrownCobalt monosulfateCobalt(II) sulphateCobalt (2+) sulfateCobalt sulfate (1:1)Cobalt(II) sulfate (1:1)
16 more reported names
Cobalt sulfate (CoSO4)Sulfuric acid, cobalt(2+) salt (1:1)Cobaltous sulfate salt (1:1)CoSO4H7965X29HXCOBALTOUS SULPHATECOBALT(2+) SULPHATECHEBI:53470COBALT SULPHATE (1:1)RefChem:127219Cobalt sulfate, 7-hydratelambda2-cobalt(2+) ion sulfateSulfuric Acid, Cobalt (2+) Salt (1:1) Heptahydrate233-334-2Cobalt sulphatecobalt(2+);sulfate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:53470

cobalt(2+) sulfate

A compound of cobalt and sulfate in which the ratio of cobalt (+2 oxidation state) to sulfate is 1:1.

Formula
Co.O4S
Average mass
154.996 g/mol
Monoisotopic mass
154.88492 Da
Formal charge
0
  • metal sulfate — is a (CHEBI:51336)
  • cobalt(2+) — has part (CHEBI:48828)
  • metal sulfate — is a (CHEBI:51336)
Additional curated names
cobalt(2+) sulfateCobalt (2+) sulfateCobalt BrownCobalt(II) sulfateCobalt monosulfateCobaltous sulfateCobalt sulfateCoSO4
Cross-references from this source
  • CAS: 10026-24-1 — KEGG COMPOUND
  • CAS: 10124-43-3 — KEGG COMPOUND
  • CAS: 10124-43-3 — ChemIDplus
  • CAS: 10124-43-3 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 268815 — Gmelin
  • REGISTRY_NUMBER: 270126 — Gmelin
  • REGISTRY_NUMBER: 270959 — Gmelin
  • REGISTRY_NUMBER: 8292 — Gmelin
  • MANUAL_X_REF: C17383 — KEGG COMPOUND
  • MANUAL_X_REF: C19215 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-02-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match24965

Attributed physical-property, hazard, environmental and use annotations.

  • pH: Acidic salts, such as cobalt sulfate ... resulting aqueous solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. Source: Hazardous Substances Data Bank (HSDB)
  • First Aid: INHALATION: move to fresh air; if breathing has stopped, begin artificial respiration and call a doctor.; INGESTION: give large amount of water; induce vomiting; call a doctor.; EYES: flush with water for at least 15 min.; consult a physician if irritation persists.; SKIN: flush with water. (USCG, 1999) Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H360F ***: May damage fertility [Danger Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P318, P321, P330, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (99.8%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (15.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H334 (> 99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (99.8%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (85.6%): May cause cancer [Danger Carcinogenicity]; H350i (14.4%): May cause cancer by inhalation [Danger Carcinogenicity]; H360 (84.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360F (10.5%): May damage fertility [Danger Reproductive toxicity]; H400 (99.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (97.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P321, P330, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2654 reports by companies from 34 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] Source: NITE-CMC
  • Health Effects: Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION: Cobalt sulfate is a red powder. It is used in storage batteries; in cobalt-electroplating baths; as drier for lithographic inks, and varnishes; in ceramics, enamels, and glazes to prevent discoloring; in cobalt pigments for decorating porcelain. HUMAN EXPOSURE AND TOXICITY: Cardiomyopathy has been observed in individuals who consume large quantities of beer where cobalt sulfate was added as a foam stabilizer. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. The substance may have effects on the heart, thyroid and bone marrow, resulting in cardiomyopathy, goiter and polycythemia. ANIMAL STUDIES: Rats and mice exposed short term to cobalt sulfate by inhalation exhibited necrosis and inflammation of the respiratory tract epithelium. Rats developed thymus necrosis and testicular atrophy. Rats exposed for 2-3 months to cobalt sulfate in the diet for 24 weeks had significant reductions in heart enzyme activity levels. Rats and mice were exposed to cobalt sulfate heptahydrate by inhalation 6 hr/day, 5 days/week for 13 weeks developed adverse effects throughout the respiratory system. At higher concentra Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: Food Chain Concentration Potential of Cobaltous Sulfate (heptahydrate): Bioconcentration of 200-1000 fold only under constant exposure. Not significant in spill conditions(1). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: Inorganic cobalt compounds are nonvolatile and released into the atmosphere in particulate form(1). Particulate-phase cobalt compounds are removed from the air by wet and dry deposition(SRC). Cobalt has been detected in atmospheric deposition(2) and in rain-snow precipitation(3). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Processing aids not otherwise specified; Plating agent; Intermediate; Pigment; Catalyst; Soil amendments (fertilizers) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cobalt sulphate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓
C=>0.01%
——

Key data

CAS
10124-43-3
EC
233-334-2
Annex
II
Entry number
454

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 457
Nearby record in the same annex

Nickel dioxide

CAS: 12035-36-8
EC: 234-823-3

What Annex II means for Cobalt sulphate

Cobalt sulphate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Cobalt sulphate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 10124-43-3 is the unique numerical identifier assigned to Cobalt sulphate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Cobalt sulphate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cobalt sulphate

This page summarizes one Annex II record for Cobalt sulphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cobalt sulphate, but confirm any final regulatory decision against the current official annex wording and source files.

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