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Annex II Entry 460 CMR24/10/2016

Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3]

Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 460
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 11113-75-0
CAS 11113-75-0PubChem CID 166709

Nickel Sulfide

Nickel Sulfide is a dark green to black colored, crystalline inorganic compound that produces toxic gases upon heating. Nickel sulfide is used in lithium batteries, as a catalyst in the petrochemical industry and is used in the manufacture of silicate-oxide nickel ores. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel sulfide is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05) — NCI Thesaurus (NCIt)

IUPAC name
nickel(2+) sulfide
Molecular formula
NiS
Molecular weight
90.76 g/mol
Exact mass
89.907413 Da
Topological polar surface area
1.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
2
Defined stereocentres
0

Also known as

Nickel monosulfideNickelous sulfideI6929D52YQRefChem:165683234-349-7240-841-2beta Nickel sulfideMononickel monosulfide
7 more reported names
Nickel sulfide crystalline particlessulfanylidenenickelnickel(2+);sulfideNickel sulfide (Ni7S6)Heptanickel hexasulpideADGNAMGSVYAHHD-UHFFFAOYSA-Nnickel (II) sulfide
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match166709

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
  • Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1314-04-1
CAS 1314-04-1CAS 16812-54-7PubChem CID 28094

Nickel sulfide (NiS)

IUPAC name
sulfanylidenenickel
Molecular formula
NiS
Molecular weight
90.76 g/mol
Exact mass
89.907413 Da
Topological polar surface area
32.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Nickel(II)sulfideNickel sulfide (millerite)MilleriteCCRIS 3733EINECS 234-349-7Nickel sulfide (amorphous)alpha-Nickel sulfide (1:1) crystallineUNII-I6929D52YQ
7 more reported names
CCRIS 6428(Sulfido)nickelMillerite (NiS)EINECS 240-841-2Nickel sulfide(ous)CS-0110975EC 240-841-2
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1A✓——
Cat. 2—✓—

Key data

CAS
16812-54-7 [1] / 11113-75-0 [2] / 1314-04-1[3]
EC
240-841-2 [1] / 234-349-7 [2] / - [3]
Annex
II
Entry number
460

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 462
Nearby record in the same annex

Carbon monoxide

CAS: 630-08-0
EC: 211-128-3
Annex II 457
Nearby record in the same annex

Nickel dioxide

CAS: 12035-36-8
EC: 234-823-3
Annex II 454
Nearby record in the same annex

Cobalt sulphate

CAS: 10124-43-3
EC: 233-334-2

What Annex II means for Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3]

Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 16812-54-7 [1] / 11113-75-0 [2] / 1314-04-1[3] is the unique numerical identifier assigned to Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3]

This page summarizes one Annex II record for Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel (II) sulfide [1]; nickel sulfide [2]; millerite[3], but confirm any final regulatory decision against the current official annex wording and source files.

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