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Annex II Entry 453 CMR17/12/2010

Cobalt dichloride

Cobalt dichloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 453
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 7646-79-9
CAS 7646-79-9PubChem CID 3032536

Cobalt chloride (cocl2)

Cobalt dichloride is a cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants. It has a role as a sensitiser, a calcium channel blocker, a two-colour indicator and an allergen. It is a cobalt salt and an inorganic chloride. It contains a cobalt(2+). — ChEBI

IUPAC name
cobalt(2+) dichloride
Molecular formula
Cl2Co
Molecular weight
129.84 g/mol
Exact mass
128.870899 Da
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

DichlorocobaltCobalt dichlorideCOBALTOUS CHLORIDECobalt muriateCobaltous dichlorideCobaltous chloride anhydrousCobalt(2+) chlorideKobalt chlorid
16 more reported names
Cobaltum muriaticumEVS87XF13WCHEBI:35696Cobalt dichloride (cocl2)NSC-51149CoCl(2)RefChem:54867lambda2-cobalt(2+) ion dichlorideTechnetium Tc-99m Exametazime and Cobaltous Chloride231-589-4Cobalt(II)chlorideCOCl2Cobalt chloride1332-82-7cobalt(2+);dichlorideCl2Co
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cobalt dichloride

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓
C=>0.01%
——

Key data

CAS
7646-79-9
EC
231-589-4
Annex
II
Entry number
453

Inventory links for Cobalt dichloride

Inventory Restriction reference
Ref 84993

COBALT CHLORIDE

CAS: 7646-79-9
EC: 231-589-4

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 454
Nearby record in the same annex

Cobalt sulphate

CAS: 10124-43-3
EC: 233-334-2
Annex II 457
Nearby record in the same annex

Nickel dioxide

CAS: 12035-36-8
EC: 234-823-3

What Annex II means for Cobalt dichloride

Cobalt dichloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Cobalt dichloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7646-79-9 is the unique numerical identifier assigned to Cobalt dichloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Cobalt dichloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cobalt dichloride

This page summarizes one Annex II record for Cobalt dichloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cobalt dichloride, but confirm any final regulatory decision against the current official annex wording and source files.

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