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Annex II Entry 455 CMR24/11/2016

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3]

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 455
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 11099-02-8
CAS 11099-02-8CAS 34492-97-2PubChem CID 14805

Nickel trioxide

Nickel Oxide can cause cancer according to California Labor Code. — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name
oxonickel
Molecular formula
NiO
Molecular weight
74.693 g/mol
Exact mass
73.930256 Da
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:1092359NICKEL OXIDENickelous oxideBunseniteNIOMononickel oxideBlack nickel oxideNickel oxide sinter 75
16 more reported names
CCRIS 431HSDB 1664Nickel Oxide NanopowderEINECS 215-215-7nickel(II) oxide, blackUNII-C3574QBZ3YCI 77777Nickel(II) oxide (1:1)oxo-nickelC.I. 77777nickel hydride oxideNICKEL MONOOXIDENickel(II) oxide, CPNickel(II) oxide, greenEC 215-215-7Nickel (II) Oxide, black
Open full PubChem recordPubChem annotations3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match14805

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H350 (98.9%): May cause cancer [Danger Carcinogenicity]; H372 (99.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H413 (99.4%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 179 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
  • Uses: Nickel oxide is used in the production of alloys. It is also used in the ceramic industry to make frits, ferrites, and porcelain glazes, and is a component of the nickel-iron battery and fuel cells. (L46) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1313-99-1
CAS 1313-99-1PubChem CID 179931

Nickel Monoxide

Nickel Monoxide is a green to black colored, inorganic compound that turns yellow and produces toxic gases upon heating. Nickel monoxide is used in the electronics, ceramics, steel and alloy industries. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and damages the lungs, kidneys, gastrointestinal tract and neurological system. Nickel monoxide is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05) — NCI Thesaurus (NCIt)

IUPAC name
nickel(2+);oxygen(2-)
Molecular formula
NiO
Molecular weight
74.693 g/mol
Exact mass
73.930256 Da
Topological polar surface area
1.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
2
Defined stereocentres
0

Also known as

Nickel (II) oxideRefChem:927711215-215-7Nickel oxide (nio)nickel(II) oxidenickel(II)oxideNickel oxide (Ni3O4)KVAWBJDCAFOHRG-UHFFFAOYSA-N
4 more reported names
NICKEL MONOXIDnickelous;oxygen(2-)NICKEL OXIDE [HSDB]NICKEL MONOXIDE [MI]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match179931

Attributed physical-property, hazard, environmental and use annotations.

  • Substance: Nickel (II) Oxide Source: NTP Technical Reports
  • NTP Technical Report: TR-451: Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1996 ) Source: NTP Technical Reports
  • Peer Review Date: 11/29/94 Source: NTP Technical Reports
  • Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: Some Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: Equivocal Evidence Source: NTP Technical Reports
  • Summary: Under the conditions of these 2-year inhalation studies, there was some evidence of carcinogenic activity of nickel oxide in male F344/N rats based on increased incidences of alveolar/bronchiolar adenoma or carcinoma (combined) and increased incidences of benign or malignant pheochromocytoma (combined) of the adrenal medulla. There was some evidence of carcinogenic activity of nickel oxide in female F344/N rats based on increased incidences of alveolar/bronchiolar adenoma or carcinoma (combined) and increased incidences of benign pheochromocytoma of the adrenal medulla. There was no evidence of carcinogenic activity of nickel oxide in male B6C3F1 mice exposed to 1.25, 2.5, or 5 mg/m3. There was equivocal evidence of carcinogenic activity of nickel oxide in female B6C3F1 mice based on marginally increased incidences of alveolar/bronchiolar adenoma in 2.5 mg/m3 females and of alveolar/bronchiolar adenoma or carcinoma (combined) in 1.25 mg/m3 females.; Exposure of rats to nickel oxide by inhalation for 2 years resulted in inflammation and pigmentation in the lung, lymphoid hyperplasia and pigmentation in the bronchial lymph nodes, and hyperplasia of the adrenal medulla (females). Expo Source: NTP Technical Reports
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H332 (13.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (17.5%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350 (67.8%): May cause cancer [Danger Carcinogenicity]; H350i (32.3%): May cause cancer by inhalation [Danger Carcinogenicity]; H360 (16.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (99.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H401 (20.2%): Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411 (20.2%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]; H413 (79.8%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P317, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2079 reports by companies from 51 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350: May cause cancer [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Sources/Uses: Used in painting porcelain, electroplating, and glass coloring; Also used to make fuel cell electrodes, ferrites (e.g. NiOFe2O3), nickel salts, nickel catalysts, varistors, and propellant for automotive air bags; [HSDB] Found in the mineral bunsenite; Used in porcelain paint; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Electroplating [Category: Plate]; Semiconductor Manufacturing [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Mining [Category: Industry]; Glass Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3]

Chemical / IUPAC name

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1A✓——

Key data

CAS
1313-99-1 [1] / 11099-02-8 [2] / 34492-97-2 [3]
EC
215-215-7 [1] / 234-323-5 [2] / - [3]
Annex
II
Entry number
455

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 454
Nearby record in the same annex

Cobalt sulphate

CAS: 10124-43-3
EC: 233-334-2
Annex II 457
Nearby record in the same annex

Nickel dioxide

CAS: 12035-36-8
EC: 234-823-3

What Annex II means for Nickel monoxide [1]; nickel oxide [2]; bunsenite [3]

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1313-99-1 [1] / 11099-02-8 [2] / 34492-97-2 [3] is the unique numerical identifier assigned to Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nickel monoxide [1]; nickel oxide [2]; bunsenite [3]

This page summarizes one Annex II record for Nickel monoxide [1]; nickel oxide [2]; bunsenite [3] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel monoxide [1]; nickel oxide [2]; bunsenite [3], but confirm any final regulatory decision against the current official annex wording and source files.

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