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Annex II Entry 1370 08/05/2013

Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III

Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1370

Chemical identity and properties

PubChem 2D chemical structure for CAS 111-46-6
CAS 111-46-6PubChem CID 8117

Diethylene Glycol

Diethylene glycol is a hydroxyether. — ChEBI

IUPAC name
2-(2-hydroxyethoxy)ethanol
Molecular formula
C4H10O3
Molecular weight
106.12 g/mol
Exact mass
106.062994177 Da
XLogP3
-1.3
Topological polar surface area
49.7 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,2'-Oxydiethanol2,2'-OxybisethanolDiglycolDiethylenglykolDigolBis(2-hydroxyethyl) ether2-Hydroxyethyl etherGlycol ether
16 more reported names
Ethanol, 2,2'-oxybis-Ethylene diglycolDigenosDicolBrecolane ndgDeactivator EDissolvant APV2,2'-Oxyethanol1,5-Dihydroxy-3-oxapentane3-Oxapentane-1,5-diolDihydroxydiethyl etherTL4N3-Oxapentamethylene-1,5-diolBis(beta-hydroxyethyl) ether2,2'-Dihydroxydiethyl ether3-Oxa-1,5-pentanediol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8117

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for diethylene glycol(SRC), using an estimated log Kow of -1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Diethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.7X10-3 mm Hg at 25 °C(4). Diethylene glycol was readily biodegraded in a sandy loam(5) suggesting that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of -1.5(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylene glycol was biodegraded partially from river water within 7 days at 20 °C, but under winter conditions of river flow and temperature (less than 8 °C) degradation was minimal(9). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol, which has a vapor pressure of 5.7X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hrs(SRC), calculated from its rate constant of 3.0X10-11 cu cm/molecule-sec at 25 °C(3). Diethylene glycol degraded 5.5% by light at a wavelength greater than 290 nm over a period of 17 hours(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Hydraulic fluids; Plasticizer; Stabilizing agent; Catalyst; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Soil amendments (fertilizers); Adhesion/cohesion promoter; Intermediate; Solvent; Anti-adhesive/cohesive; Anti-freeze agent; Other; Freeze-thaw additive; Lubricating agent; Processing aids not otherwise specified; Monomers; Fuel agents; Heat transferring agent Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Fuel agents; Heat transferring agent; Processing aids not otherwise specified; Surfactant (surface active agent); Monomers; Wetting agent (non-aqueous); Other; CBI; Lubricating agent; Freeze-thaw additive; Solvent; Anti-freeze agent; Anti-adhesive/cohesive; Adhesion/cohesion promoter; Intermediate; Emulsifier; Catalyst; Corrosion inhibitor; Filler; Not Known or Reasonably Ascertainable; Hydraulic fluids; Dehydrating agent (desiccant) Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a humectant (tobacco, casein, synthetic sponges, composition corks, glues, gelatin, and paper products), a dehydrating agent (plasticizers, surfactants, and natural gas), a lubricating and finishing agent (wool, worsted, cotton, rayon, and silk), a solvent for vat dyes, an intermediate (triethylene glycol and diethylene glycol dinitrate), a petroleum extraction solvent, and a monomer (unsaturated polyester resins and polyols for polyurethane); Also used in lacquers, cosmetics, antifreeze solutions for sprinkler systems; water seals for gas tanks, brake fluids, lubricants, mold release agents, and inks; [HSDB] Used mainly to produce unsaturated polyester resins, polyols, and polyurethanes; [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Production of polyurethane and unsaturated polyester resins, triethylene glycol; textile softener; petroleum solvent extraction; dehydration of natural gas, plasticizers, and surfactants; solvent for nitrocellulose and many dyes and oils; humectant for tobacco, casein, synthetic sponges, paper products; cork compositions, bookbinding adhesives, dyeing assistant, cosmetics, antifreeze solutions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In antifreeze soln for sprinkler systems; for water seals for gas tank; lubricating and finishing agent for wool, worsted, cotton, rayon and silk; solvent for vat dyes; in composition corks, glues, gelatin, casein, and pastes to prevent drying out. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Diethylene glycol is used in gas conditioning and in the permanent antifreeze formulations; as a constituent of brake fluids, lubricants, mold release agents, and inks; as a softening agent for textiles; as a plasticizer for cork, adhesives, paper, packaging materials, and coatings; as an intermediate in the prodn of explosive diethylene glycol dinitrate; and as an intermediate in the production of certain resins, morpholine, and diethylene glycol esters and ethers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In lacquer industry and in cosmetics Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for DIETHYLENE GLYCOL (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
111-46-6
EC
203-872-2
Annex
II
Entry number
1370

Inventory links for Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III

Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 111-46-6 is the unique numerical identifier assigned to Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III

This page summarizes one Annex II record for Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Diethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III, but confirm any final regulatory decision against the current official annex wording and source files.

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