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Annex II Entry 1374 23/06/2015

Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben

Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1374

Chemical identity and properties

PubChem 2D chemical structure for CAS 4191-73-5
CAS 4191-73-5PubChem CID 20161

Isopropylparaben

Isopropylparaben is a 4-hydroxybenzoate ester. — ChEBI

IUPAC name
propan-2-yl 4-hydroxybenzoate
Molecular formula
C10H12O3
Molecular weight
180.20 g/mol
Exact mass
180.078644241 Da
XLogP3
2.8
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Isopropyl 4-hydroxybenzoateIsopropyl p-hydroxybenzoatep-Hydroxybenzoic acid isopropyl esterBenzoic acid, 4-hydroxy-, 1-methylethyl esterA6EOX47QK01-Methylethyl-4-hydroxybenzoate4-Hydroxybenzoic acid, 1-methylethyl esteri-Pr 4-OH-benzoate
16 more reported names
RefChem:565998224-069-3isopropyl parabenp-Oxybenzoesaureisopropylester4-Hydroxybenzoic Acid Isopropyl EsterUNII-A6EOX47QK0EINECS 224-069-3Isopropyl-4-hydroxybenzoateBENZOIC ACID, p-HYDROXY-, ISOPROPYL ESTERCS-W017207AS-11940Isopropylhydroxybenzoatemethylethyl 4-hydroxybenzoate1-Methylethyl 4-hydroxybenzoatep-Oxybenzoesaureisopropylester [German]BRN 2641564
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben

Regulatory information

Regulation

(EU) 2014/358

See every entry this act set

Key data

CAS
4191-73-5
EC
224-069-3
Annex
II
Entry number
1374

Inventory links for Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben

Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 4191-73-5 is the unique numerical identifier assigned to Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben

This page summarizes one Annex II record for Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Isopropyl 4-hydroxybenzoate (INCI: Isopropylparaben) Sodium salt or Sats of Isopropylparaben, but confirm any final regulatory decision against the current official annex wording and source files.

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