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Annex II Entry 1375 16/01/2015

Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1375

Chemical identity and properties

PubChem 2D chemical structure for CAS 4247-02-3
CAS 4247-02-3PubChem CID 20240

Isobutylparaben

Isobutylparaben is a 4-hydroxybenzoate ester. — ChEBI

IUPAC name
2-methylpropyl 4-hydroxybenzoate
Molecular formula
C11H14O3
Molecular weight
194.23 g/mol
Exact mass
194.094294304 Da
XLogP3
3.4
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Isobutyl 4-hydroxybenzoateisobutyl parabenIsobutyl p-hydroxybenzoateIsobutyl-4-hydroxybenzoateIsobutyl parahydroxybenzoateBenzoic acid, 4-hydroxy-, 2-methylpropyl esterisobutyl-p-hydroxybenzoateBENZOIC ACID, p-HYDROXY-, ISOBUTYL ESTER
16 more reported names
0QQJ25X58Gi-BHBRefChem:923642224-208-84-Hydroxybenzoic Acid Isobutyl Esterp-Hydroxybenzoic acid isobutyl esterChemDiv2_000057p-OxybenzoesaureisobutylesterCHEBI:1782564-Hydroxybenzoic acid-isobutyl esterISOBUTYL PARA HYDROXY BENZOATEp-Hydroxybenzoic acid sec-butyl ester3-10-00-00308 (Beilstein Handbook Reference)SR-01000389342-12-Methylpropyl 4-Hydroxybenzoate (Isobutyl Parahydroxybenzoate)CCRIS 2463
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

Regulatory information

Regulation

(EU) 2014/358

See every entry this act set

Key data

CAS
4247-02-3 / 224-208-8
EC
84930-15-4 / 284-595-4
Annex
II
Entry number
1375

Inventory links for Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

Inventory Restriction reference
Ref 34612

ISOBUTYLPARABEN

CAS: 4247-02-3
EC: 224-208-8

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 4247-02-3 / 224-208-8 is the unique numerical identifier assigned to Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben

This page summarizes one Annex II record for Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Isobutyl 4-hydroxybenzoate (INCI: Isobutylparaben) /Sodium salt or Salts of Isobutylparaben, but confirm any final regulatory decision against the current official annex wording and source files.

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