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Annex II Entry 1364 08/05/2013

1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products

1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1364

Chemical identity and properties

PubChem 2D chemical structure for CAS 128-80-3
CAS 128-80-3PubChem CID 31416

Cyanine Green G Base

IUPAC name
1,4-bis(4-methylanilino)anthracene-9,10-dione
Molecular formula
C28H22N2O2
Molecular weight
418.5 g/mol
Exact mass
418.168127949 Da
XLogP3
7.8
Topological polar surface area
58.2 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

D.C. Green No. 61,4-di-4-toluidinoanthraquinoneRefChem:416470Solvent green 3Quinizarin Green SS1,4-Bis(p-tolylamino)anthracene-9,10-dioneC.I. Solvent Green 3Waxoline Green G
16 more reported names
Sudan Green 4BQuinazarin greenArlosol Green BOrganol Green JQuinizarine Green BaseArlosol Green BSAmaplast Green OZArlosol Green BSS11091 GreenWaxoline GreenMacro-lex Green 5BD & C Green no. 6Nitro Fast Green GBOrganol Fast Green JC-Green 10D&C Green 6
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31416

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 97.8% (2848 of 2913) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 2848 of 2913 companies (only 2.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2913 reports by companies from 14 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2848 of 2913 reports by companies.; There are 11 notifications provided by 65 of 2913 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Environmental Bioconcentration: An estimated BCF of 500 was calculated in fish for D&C Green No. 6(SRC), using an estimated log Kow of 8.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4.8X10+6(SRC), determined from a structure estimation method(2), indicates that D&C Green No. 6 is expected to be immobile in soil(SRC). Volatilization of D&C Green No. 6 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-16 atm-cu m/mole(SRC), using a fragment constant estimation method(3). D&C Green No. 6 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.0X10-13 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). D&C Green No. 6 was shown to be susceptible to photolysis on soil, with two photoproducts detected, not identified(5). Biodegradation data in soil were not available(SRC, 2011). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4.8X10+6(SRC), determined from a structure estimation method(2), indicates that D&C Green No. 6 is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.5X10-16 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 500(SRC), from an estimated log Kow of 8.69(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Biodegradation data in water were not available(SRC, 2011). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), D&C Green No. 6, which has an estimated vapor pressure of 7.0X10-13 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase D&C Green No. 6 may be removed from the air by wet or dry deposition(SRC). D&C Green No. 6 absorbs light at wavelengths 644 nm(3), and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used for sutures; Approved for external drugs and cosmetics; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Coloring fats, oils, waxes, hydrocarbon solvents, hydrocarbon-base wood stains, cellulose acetate, polystyrene and soap, and in the preparation of oleic or stearic rotogravure inks. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Coloring contact lenses; ... coloring polyethylene terephthalate surgical sutures, including sutures for ophthalmic use; ... coloring polyglycolic acid surgical sutures with diameter greater than U.S.P. size 8-0, including sutures for ophthalmic use; ... coloring poly(glycolic acid-co-trimethylene carbonate) sutures (also referred to as 1,4-dioxan-2,5-dione polymer with 1,3-dioxan-2-one) for general surgical use; and ... coloring polymethylmethacrylate support haptics of intraocular lenses. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Military smoke dye grenades used for communication Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

Identified ingredients

Key data

CAS
128-80-3
EC
204-909-5
Annex
II
Entry number
1364

Inventory links for 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products

Inventory Restriction reference
Ref 32785

CI 61565

CAS: 128-80-3
EC: 204-909-5
Inventory Restriction reference
Ref 38150

SOLVENT GREEN 3

CAS: 128-80-3
EC: 204-909-5

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex IV 91
Shared CAS number

CI 61565

CAS: 128-80-3
EC: 204-909-5

What Annex II means for 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products

1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 128-80-3 is the unique numerical identifier assigned to 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products

This page summarizes one Annex II record for 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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