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Annex II Entry 1372 CMR24/11/2016

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1372
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 51-19-4
CAS 51-19-4PubChem CID 5800

2-Aminophenol hydrochloride

IUPAC name
2-aminophenol;hydrochloride
Molecular formula
C6H8ClNO
Molecular weight
145.59 g/mol
Exact mass
145.0294416 Da
Topological polar surface area
46.3 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
2
Covalent units
2
Defined stereocentres
0

Also known as

Phenol, 2-amino-, hydrochlorideo-Hydroxyaniline hydrochloridePhenol, o-amino-, hydrochlorideNSC 165648RefChem:465183Phenol, 2-amino-, hydrochloride (9CI)621-209-9o-Aminophenol hydrochloride
9 more reported names
Phenol, 2-amino-, hydrochloride (1:1)2-aminophenol HCl2-aminophenol HCl saltO-AMINOPHENYL HYDROCHLORIDENSC-1656482-Aminophenol--hydrogen chloride (1/1)AS-87300DB-051919A0391
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 95-55-6
CAS 95-55-6PubChem CID 5801

2-Aminophenol

2-aminophenol is the aminophenol which has the single amino substituent located ortho to the phenolic -OH group. It has a role as a bacterial metabolite. — ChEBI

IUPAC name
2-aminophenol
Molecular formula
C6H7NO
Molecular weight
109.13 g/mol
Exact mass
109.052763847 Da
XLogP3
0.6
Topological polar surface area
46.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

O-AMINOPHENOLo-Hydroxyaniline2-HydroxyanilinePhenol, 2-amino-2-Amino-1-hydroxybenzeneFouramine OPBenzofur GGPelagol Grey GG
16 more reported names
Pelagol 3GANako Yellow 3GABASF ursol 3GAZoba 3GAPhenol, o-amino-Questiomycin Bo-Hydroxyphenylamineortho-aminophenol2-HydroxyanalineNako Yellow gaParadone Olive Green B1-Amino-2-hydroxybenzene1-Hydroxy-2-aminobenzeneC.I. Oxidation Base 172-AminobenzenolCI Oxidation Base 17
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

Chemical / IUPAC name

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2—✓—

Key data

CAS
95-55-6 [1]/67845-79-8 [2]/51-19-4 [3]
EC
202-431-1 [1]/267-335-4 [2]/621-209-9 [3]
Annex
II
Entry number
1372

Inventory links for 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

Inventory Restriction reference
Ref 35572

O-AMINOPHENOL

CAS: 95-55-6
EC: 202-431-1

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 95-55-6 [1]/67845-79-8 [2]/51-19-4 [3] is the unique numerical identifier assigned to 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3]

This page summarizes one Annex II record for 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2-aminophenol [1]; bis(2-hydroxyanilinium) sulfate [2]; 2-Aminophenol Hydrochloride [3], but confirm any final regulatory decision against the current official annex wording and source files.

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