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Annex II Entry 1304 21/10/2010

N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products

N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1304

Chemical identity and properties

PubChem 2D chemical structure for CAS 66612-11-1
CAS 66612-11-1PubChem CID 3017692

N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-YL]acetamide

IUPAC name
N-[2-[(2-chloro-4-oxocyclohexa-2,5-dien-1-ylidene)amino]-5-hydroxy-4-methoxyphenyl]acetamide
Molecular formula
C15H13ClN2O4
Molecular weight
320.73 g/mol
Exact mass
320.0563846 Da
XLogP3
1.5
Topological polar surface area
88.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

HC Yellow no. 8F1NQ5U8325UNII-F1NQ5U8325N-(6-((2-Chloro-4-hydroxyphenyl)imino)-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl)acetamideN-{2-[(2-CHLORO-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)AMINO]-5-HYDROXY-4-METHOXYPHENYL}ACETAMIDEEINECS 266-424-5HC Yellow 8Yellow No. 8
8 more reported names
IMEXINE ILDNCKSSGISBCYQW-UHFFFAOYSA-NN-(6-((2-Chloro-4-hydroxyphenyl)imino)-4-methyoxy-3-oxo-1,4-cyclo- hexadien-1-yl)acetamideAcetamide, N-(6-((2-chloro-4-hydroxyphenyl)imino)-4-methyoxy-3-oxo-1,4-cyclo- hexadien-1-yl)-N-(2'-Chloro-4'-hydroxyphenyl)-3-acetylamino-6-methoxy-1,4-benzoq- uinoneimineN-(2'-CHLORO-4'-HYDROXYPHENYL)-3-ACETYLAMINO-6-METHOXY-1,4-BENZOQUINONEIMINEACETAMIDE, N-(6-((2-CHLORO-4-HYDROXYPHENYL)IMINO)-4-METHOXY-3-OXO-1,4-CYCLOHEXADIEN-1-YL)-N-{(6E)-6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxocyclohexa-1,4-dien-1-yl}acetamide
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
66612-11-1
EC
266-424-5
Annex
II
Entry number
1304

Inventory links for N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products

Inventory Restriction reference
Ref 34223

HC YELLOW NO. 8

CAS: 66612-11-1
EC: 266-424-5

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products

N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 66612-11-1 is the unique numerical identifier assigned to N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No 8) and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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