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Annex II Entry 1004 CMR17/12/2010

tris(2-Chloroethyl) phosphate

tris(2-Chloroethyl) phosphate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1004
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 115-96-8
CAS 115-96-8PubChem CID 8295

Tris(2-chloroethyl) phosphate

Tris(2-chloroethyl) phosphate is a trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid. It is an organochlorine compound and a trialkyl phosphate. — ChEBI

IUPAC name
tris(2-chloroethyl) phosphate
Molecular formula
C6H12Cl3O4P
Molecular weight
285.5 g/mol
Exact mass
283.953879 Da
XLogP3
1.3
Topological polar surface area
44.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Tris(2-chloroethyl)phosphateCelluflexDisflamoll TCACelluflex CEFFyrol CEFNiax 3CFNiax Flame Retardant 3CFTrichlorethyl phosphate
16 more reported names
TRI(2-CHLOROETHYL) PHOSPHATE2-Chloroethanol phosphateTris(2-chloroethyl) orthophosphateTris(chloroethyl)phosphateTris(beta-chloroethyl) phosphateEthanol, 2-chloro-, phosphate (3:1)Fyrol CFNCI-C60128Tri-beta-chloroethyl phosphatePhosphoric acid, tris(2-chloroethyl)esterTris-(2-chloroethyl)fosfatAI3-1502332IVO568B0NSC-3213CHEBI:35037tri(chloroethyl)phosphate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8295

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360F ***: May damage fertility [Danger Reproductive toxicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (97.3%): Harmful if swallowed [Warning Acute toxicity, oral]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H360 (86.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360F (13%): May damage fertility [Danger Reproductive toxicity]; H411 (99.9%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P273, P280, P301+P317, P318, P330, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 801 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P308+P316, P318, P319, P321, P330, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P330, P332+P317, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Toxicity Summary: IDENTIFICATION AND USE: (Tris(2-chloroethyl) phosphate is a Clear, transparent liquid. It is used primarily as an additive plasticizer and viscosity regulator with flame-retarding properties for polyurethane, polyesters, polyvinyl chloride and other polymers. HUMAN EXPOSURE AND TOXICITY: Tris(2-chloroethyl) phosphate did not consistently demonstrate detectable unscheduled DNA synthesis with and without metabolic activation and failed to show a dose-response relationship in human WI-38 cells. ANIMAL STUDIES: In repeat dose studies Tris(2-chloroethyl) phosphate caused adverse effects on the brain (hippocampal lesions in rats), liver and kidneys. Non-irritant to eyes, but conflicting reports in the literature on skin irritation, has not been tested for sensitization potential. Not teratogenic. It adversely affects the fertility of male rats and mice. In vitro mutagenicity test results were inconsistent and an in vivo micronucleus test gave equivocal results. Tris(2-chloroethyl) phosphate causes benign and malignant tumors at various organ sites in rats and mice. A very high oral dose caused some inhibition of plasma cholinesterase and brain neuropathy target esterase, but did not caus Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A BCF of 2.2 was determined for tris(2-chloroethyl) phosphate using killifish (Oryzias latipes) exposed to the chemical in static water for 72 hr(1). A BCF of 0.9 was obtained for goldfish (Carassius auratus) under identical conditions(1). BCFs of 1.1 and 1.3 were determined using killifish exposed to 12.7 ppm of tris(2-chloroethyl) phosphate for 5 days and 2.3 ppm for 11 days, respectively, in a continuous flow water system(2). BCFs of <1.2-5.1 and 0.6-0.8 were reported in carp (Cyprinus carpio) which were exposed to tris(2-chloroethyl) phosphate at 0.1 and 1 ppm, respectively, over a 6-week period(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a structure estimation method(2), indicates that tris(2-chloroethyl) phosphate is expected to have moderate mobility in soil(SRC). Volatilization of tris(2-chloroethyl) phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 6.13X10-2 mm Hg(3), and water solubility, 7000 mg/L(4). Tris(2-chloroethyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a structure estimation method(2), indicates that tris(2-chloroethyl) phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 6.13X10-2 mm Hg(4), and water solubility, 7000 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 19 and 140 days, respectively(SRC). Tris(2-chloroethyl) phosphate may undergo hydrolysis in the environment based on an estimated hydrolysis half-life of 20 days at pH 5 to 9(2). According to a classification scheme(6), measured BCF values of 0.6-5.1 in fish(7-9), suggest bioconcentration in aquatic organisms is low(SRC). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(7) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tris(2-chloroethyl) phosphate, which has a vapor pressure of 6.13X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tris(2-chloroethyl) phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its rate constant of 2.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tris(2-chloroethyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Flame retardant in plastics, especially in flexible foams used in automobiles and furniture, and in rigid foams used for building insulation. [IARC] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: ... Used primarily as an additive plasticiser and viscosity regulator with flame-retarding properties for polyurethane, polyesters, polyvinyl chloride and other polymers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Flame-retardant plasticizer Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used in rigid polyurethane and polyisocyanurate foams, carpet backing, flame-laminated and rebonded flexible foam, flame-retardant coatings, most classes of thermosets, adhesives (gv), cast acrylic sheet, and wood-resin composites such as particle board. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Emulsions of tris(2-chloroethyl) phosphate, blended with a binder such as a vinyl or acrylic emulsion, can be used for applications such as the backcoating of upholstery. It can be used as a secondary plasticizer in polyvinyl chloride to suppress the flammability resulting from plasticizers such as phthalates. Where a particularly high degree of flame retardancy is required, it can be used in combination with the aromatic phosphate plasticizers. Such formulations can serve as an alternative to the use of antimony oxide in plasticized vinyl polymers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for TRIS(2-CHLOROETHYL) PHOSPHATE (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Tris(2-chloroethyl) phosphate is used as a flame retardant, plasticizer, and viscosity regulator in various types of polymers including polyurethanes, polyester resins, and polyacrylates. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

tris(2-Chloroethyl) phosphate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓
Cat. 2✓——

Key data

CAS
115-96-8
EC
204-118-5
Annex
II
Entry number
1004

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1008
Nearby record in the same annex

Simazine

CAS: 122-34-9
EC: 204-535-2
Annex II 999
Nearby record in the same annex

Hexane

CAS: 110-54-3
EC: 203-777-6

What Annex II means for tris(2-Chloroethyl) phosphate

tris(2-Chloroethyl) phosphate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. tris(2-Chloroethyl) phosphate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 115-96-8 is the unique numerical identifier assigned to tris(2-Chloroethyl) phosphate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

tris(2-Chloroethyl) phosphate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record tris(2-Chloroethyl) phosphate

This page summarizes one Annex II record for tris(2-Chloroethyl) phosphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for tris(2-Chloroethyl) phosphate, but confirm any final regulatory decision against the current official annex wording and source files.

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