4'-Ethoxy-2-benzimidazoleanilide
4'-Ethoxy-2-benzimidazoleanilide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
N-(4-Ethoxyphenyl)-1H-benzimidazole-2-carboxamide
- IUPAC name
- N-(4-ethoxyphenyl)-1H-benzimidazole-2-carboxamide
- Molecular formula
- C16H15N3O2
- Molecular weight
- 281.31 g/mol
- Exact mass
- 281.116426730 Da
- XLogP3
- 3.0
- Topological polar surface area
- 67.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID90558641
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P273, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P203, P273, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
4'-Ethoxy-2-benzimidazoleanilide
Regulatory information
SCCS opinions
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 2 | — | ✓ | — |
Key data
Related records for 4'-Ethoxy-2-benzimidazoleanilide
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
tris(2-Chloroethyl) phosphate
Nickel dihydroxide [1]; nickel hydroxide [2]
5,6,12,13-Tetrachloroanthra(2,1,9-def:6,5,10-d'e'f')diisoquinoline-1,3,8,10(2H,9H)-tetrone
4-[4-(1,3-Dihydroxyprop-2-yl)phenylamino]-1,8-dihydroxy-5-nitroanthraquinone
(+/-)-2-(2,4-Dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl-1,1,2,2-tetrafluoroethylether (Tetraco…
Bis(cyclopentadienyl)-bis(2,6-difluoro-3-(pyrrol-1-yl)-phenyl)titanium
2-Methoxyethoxy)ethanol (Diethylene glycol monomethyl ether; DEGME)
N,N,N',N'-Tetraglycidyl-4,4'-diamino-3,3'-diethyldiphenylmethane
What Annex II means for 4'-Ethoxy-2-benzimidazoleanilide
4'-Ethoxy-2-benzimidazoleanilide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record 4'-Ethoxy-2-benzimidazoleanilide
This page summarizes one Annex II record for 4'-Ethoxy-2-benzimidazoleanilide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 4'-Ethoxy-2-benzimidazoleanilide, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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