Annex II
Entry 1006
CMR29/10/2010
Nickel dihydroxide [1]; nickel hydroxide [2]
Nickel dihydroxide [1]; nickel hydroxide [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1006
CMR
Chemical identity and properties
CAS 11113-74-9CAS 12054-48-7PubChem CID 61534
Nickel Dihydroxide
Nickel hydroxide appears as a fine green powder. Slightly soluble in water and denser than water. Primary hazard is threat to the environment. Immediate steps should be taken to limit spread to the environment. — CAMEO Chemicals
- IUPAC name
- nickel(2+) dihydroxide
- Molecular formula
- H2NiO2
- Molecular weight
- 92.708 g/mol
- Exact mass
- 91.940821 Da
- Topological polar surface area
- 2.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 2
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
Nickel(II) hydroxideNICKEL HYDROXIDEGreen nickel oxideNickelous hydroxideNickel(2+) hydroxideL8UW92NW6JNiOH2NICKELDIOL
13 more reported names
RefChem:165670234-348-1235-008-5nickel hydroxide (II)NICKEL HYDROXIDE (Ni(OH)2)nickel(2+);dihydroxidenickel(II)hydroxideCCRIS 429EINECS 234-348-1H2NiO2NICKEL HYDROXIDE [MI]NICKEL HYDROXIDE [HSDB]N1202
External database identifiers
- EPA DTXSID:DTXSID90274011
- PubMed:24278546
- PubMed:20864429
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match61534
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 752 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: Ignites in air at about 400 °C. Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Black powder Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Green crystals, hexagonal Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Light green microcrystalline powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 4.1 at 68 °F (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 4.1 Source: Hazardous Substances Data Bank (HSDB)
- Density: 4.1 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: Ignites in air at about 752.0 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 752 °F Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Melting Point: 446 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: Decomposes at 230 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Nickel hydroxide appears as a fine green powder. Slightly soluble in water and denser than water. Primary hazard is threat to the environment. Immediate steps should be taken to limit spread to the environment. Source: CAMEO Chemicals
- Physical Description: Dry Powder; Other Solid; Wet Solid; CBI Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Green crystals; [HSDB] Water insoluble; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: SOL IN DIL ACIDS, IN AMMONIA Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOL IN AMMONIUM HYDROXIDE, ACIDS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 0.013 G/100 CC COLD WATER Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Inhalation (L41) ; oral (L41) ; dermal (L41) Source: Toxin and Toxin Target Database (T3DB)
- First Aid: Consult a physician.; INHALATION: Remove from source.; EYES: Wash with copious amounts of water and get medical attention.; SKIN: Wash with soap and water.; INGESTION: Give 2 to 3 glasses of water and induce vomiting. Consult physician. (USCG, 1999) Source: CAMEO Chemicals
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H360D ***: May damage the unborn child [Danger Reproductive toxicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (98.4%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H330 (10.6%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H332 (89.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (99.7%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (99.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (72.4%): May cause cancer [Danger Carcinogenicity]; H350i (27.6%): May cause cancer by inhalation [Danger Carcinogenicity]; H360 (72.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360D (27.6%): May damage the unborn child [Danger Reproductive toxicity]; H372 (99.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (99.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P316, P317, P318, P319, P320, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 377 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (100%): May cause cancer [Danger Carcinogenicity]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
- Health Effects: The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41) Source: Toxin and Toxin Target Database (T3DB)
- Toxicity Summary: Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, Source: Toxin and Toxin Target Database (T3DB)
- Consumer Uses: Catalyst; Other Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Catalyst; Intermediate; Other; Alloys; Conductive agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used to make nickel-cadmium batteries and catalysts; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Battery Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Mfr of nickel salts Source: Hazardous Substances Data Bank (HSDB)
- Uses: USED IN NICKEL-CADMIUM BATTERIES Source: Hazardous Substances Data Bank (HSDB)
- Uses: HYDROGENATION OF FINELY POWDERED NEWSPAPER WITH NICKEL HYDROXIDE CATALYST PRODUCES CONVERSION IN HIGH YIELDS OF CELLULOSIC FEED MATERIALS TO LIQ HYDROCARBON FUELS. Source: Hazardous Substances Data Bank (HSDB)
- Uses: CHEM INT FOR NICKEL CATALYSTS & NICKEL SALTS Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for NICKEL HYDROXIDE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Nickel hydroxide is used in rechargeable battery electrodes. (L44) Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Nickel dihydroxide [1]; nickel hydroxide [2]
Regulatory information
Other directives
(EC) 2009/790
SCCS opinions
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1A | ✓ | — | — |
| Cat. 1B | — | — | ✓ |
| Cat. 2 | — | ✓ | — |
Key data
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What Annex II means for Nickel dihydroxide [1]; nickel hydroxide [2]
Nickel dihydroxide [1]; nickel hydroxide [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Yes. Nickel dihydroxide [1]; nickel hydroxide [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 12054-48-7 [1] / 11113-74-9 [2] is the unique numerical identifier assigned to Nickel dihydroxide [1]; nickel hydroxide [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
Nickel dihydroxide [1]; nickel hydroxide [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record Nickel dihydroxide [1]; nickel hydroxide [2]
This page summarizes one Annex II record for Nickel dihydroxide [1]; nickel hydroxide [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Nickel dihydroxide [1]; nickel hydroxide [2], but confirm any final regulatory decision against the current official annex wording and source files.
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