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Annex II Entry 1007 CMR15/10/2010

N,N-Dimethylaniline

N,N-Dimethylaniline is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1007
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 121-69-7
CAS 121-69-7PubChem CID 949

N,N-Dimethylaniline

N,N-dimethylaniline is a tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups. It is a dimethylaniline and a tertiary amine. — ChEBI

IUPAC name
N,N-dimethylaniline
Molecular formula
C8H11N
Molecular weight
121.18 g/mol
Exact mass
121.089149355 Da
XLogP3
2.3
Topological polar surface area
3.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

DimethylanilineDimethylphenylamineN,N-DimethylbenzenamineN,N-DimethylphenylamineBenzenamine, N,N-dimethyl-(Dimethylamino)benzeneN,N-DimethylbenzeneamineDwumetyloanilina
16 more reported names
Aniline, N,N-dimethyl-Versneller NL 63/10NCI-C56428NL 63-10PNSC-7195CHEBI:16269RefChem:6047CHEBI:23806204-493-5N,N-(Dimethylamino)benzeneDimethyl-phenyl-amineDimethylaniline, N,N-NSC 7195N,N-Dimethyl-N-phenylamineN,N-DIMETHYL-ANILINEdimethyl aniline
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match949

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • ERG2024, Guide 153 (N,N-Dimethylaniline): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301+H311+H331 (11.3%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H319 (27.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (99.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P321, P330, P337+P317, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 799 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 4.8% (9 of 189) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H252 (59.8%): Self-heating in large quantities; may catch fire [Warning Self-heating substances and mixtures]; H317 (59.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (75.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H400 (94.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (95.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P235, P261, P264+P265, P272, P273, P280, P302+P352, P305+P354+P338, P317, P321, P333+P317, P362+P364, P391, P407, P410, P413, P420, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 189 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 9 of 189 reports by companies.; There are 9 notifications provided by 180 of 189 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: N,N-Dimethylaniline is a pale-yellow, oily liquid with amine-like odor that solidifies below 36 degrees F. It is used as a solvent; an intermediate in the manufacture of vanilin, methyl violet, other dyes, and Michler's ketone; as a reagent; as a catalytic hardener in certain fiberglass resins; and as an acid scavenger or acceptor in the manufacture of semisynthetic penicillins and cephalosporins. HUMAN EXPOSURE AND TOXICITY: N,N-Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect notably, methemoglobinemia. The human lethal oral dose is 50 mg/kg. Short-term exposure: contact may irritate or burn the eyes, and may irritate the nose and throat. It can be absorbed through the skin, thereby increasing exposure. Swallowing the liquid may cause aspiration into the lungs with the risk of chemical pneumonia. The chemical may affect the blood, resulting in formation of methemoglobin. Symptoms of anoxia, cyanosis, weakness, dizziness, ataxia. Symptoms may be delayed. Long term exposure: repeated or prolonged contact with skin may cause dermatitis. While this chemical has not been identified as a reproducti Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A BCF of 5.4 was measured in fish for N,N-dimethylaniline, at a concentration of 0.5 ppm, using carp (Cyprinus carpio) which were exposed over a 6-week period(1). According to a classification scheme(2), this BCF suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 182(2), indicates that N,N-dimethylaniline is expected to have moderate mobility in soil(SRC). The pKa of N,N-dimethylaniline is 5.15(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of N,N-dimethylaniline from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.7X10-5 atm-cu m/mole(SRC), based upon its vapor pressure, 0.76 mm Hg(5), and water solubility, 1,450 mg/L(6). N,N-Dimethylaniline is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). Utilizing the Japanese MITI test, 1.9% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 182(2), indicates that N,N-dimethylaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.7X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 0.7 mm Hg(4), and water solubility, 1,450 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives of the neutral species for a model river and model lake are 20 hrs and 10 days, respectively(SRC). N,N-Dimethylaniline is degraded in aqueous environments by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in water is estimated to be 34 days(SRC), calculated from its rate constant of 1.4X10+10 cu cm/molecule-sec(6). According to a classification scheme(7), a measured BCF of 5.4(8) suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 1.9% of the Theoretical BOD was reached in 2 weeks(8) indicating that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N,N-dimethylaniline, which has a vapor pressure of 0.7 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N,N-dimethylaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hrs(SRC), calculated from its rate constant of 1.48X10-10 cu cm/molecule-sec at 25 °C(3). Vapor-phase N,N-dimethylaniline is degraded in the atmosphere by reaction with photochemically-produced ozone radicals(SRC); the half-life for this reaction in air is estimated to be 29 hrs(SRC), calculated from the rate constant of 9.1X10-18 cu cm/molecule-sec at 25 °C(4). Night-time reaction with nitrate radicals may also contribute to the atmospheric transformation of N,N-dimethylaniline(4). A dilute aqueous solution of N,N-dimethylaniline exposed to fluorescent lamps having a continuous spectrum from 300-400 nm resulted in a 50% degradation in approximately 14 min(5); therefore, N,N-dimethylaniline may be susceptible to direct photolysis by sunli Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
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NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N,N-Dimethylaniline

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
121-69-7
EC
204-493-5
Annex
II
Entry number
1007

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1008
Nearby record in the same annex

Simazine

CAS: 122-34-9
EC: 204-535-2
Annex II 1013
Nearby record in the same annex

Phosphamidon

CAS: 13171-21-6
EC: 236-116-5

What Annex II means for N,N-Dimethylaniline

N,N-Dimethylaniline is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. N,N-Dimethylaniline is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 121-69-7 is the unique numerical identifier assigned to N,N-Dimethylaniline by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

N,N-Dimethylaniline has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record N,N-Dimethylaniline

This page summarizes one Annex II record for N,N-Dimethylaniline from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N,N-Dimethylaniline, but confirm any final regulatory decision against the current official annex wording and source files.

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