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ProhibitedBinding ruleNZOriginal is EnglishOfficial-source import checked

2-Ethoxyethanol [1]

New Zealand Cosmetic Products Group Standard Schedule 4, reference 666.

All New Zealand recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
New Zealand Cosmetic Products Group Standard Schedule 4, reference 666.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
2-Ethoxyethanol [1]
CAS
110-80-5
EC
203-804-1
Identity mapping
cas_number
Linked ingredient
ETHOXYETHANOL
Search this identity across the siteCAS 110-80-5EC 203-804-1

Linked CosIng identity data

Names and aliases

ETHOXYETHANOL

EU inventory restriction note: II/666

Recorded cosmetic function: SOLVENT, VISCOSITY CONTROLLING

Function pages:SOLVENT, VISCOSITY CONTROLLING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 110-80-5
CAS 110-80-5PubChem CID 8076

Verified chemistry for CAS 110-80-5

Glycol monoethyl ether

2-ethoxyethanol is a hydroxyether that is the ethyl ether derivative of ethylene glycol. It has a role as a protic solvent and a teratogenic agent. It is a primary alcohol and a glycol ether. It is functionally related to an ethylene glycol. — ChEBI

IUPAC name
2-ethoxyethanol
Molecular formula
C4H10O2
Molecular weight
90.12 g/mol
Exact mass
90.068079557 Da
Monoisotopic mass
90.068079557 Da
XLogP3
-0.3
Topological polar surface area
29.5 Ų
Molecular complexity
21.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
6
Covalent units
1

Names and synonyms reported to PubChem

ETHYLENE GLYCOL MONOETHYL ETHEREthyl cellosolveEmkanolHydroxy etherEthanol, 2-ethoxy-2-Ethoxyethan-1-OlDowanol EEEthylene glycol ethyl ether
16 more reported names
Jeffersol EECellosolve solventPlastiazan 602-Ethoxyethyl alcoholSolvidEthylethylene glycolEktasolve EEEGEEbeta-EthoxyethanolSolvuloseBikanol E 1Etoksyetylowy alkoholDowanol 8CelosolvEthyl ethylene glycolGlycol ether EE
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
0
3D hydrophobes
0
3D acceptor features
2
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CCOCCO
InChI
InChI=1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3
InChIKey
ZNQVEEAIQZEUHB-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8076

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 127 (Ethylene glycol monoethyl ether): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P316, P318, P321, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (27.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H331 (74.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (25.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H360 (88.4%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (16.5%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P316, P317, P318, P321, P330, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1236 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P332+P317, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): The ingredient is unsafe for use in cosmetics Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Ethylene Glycol Monoethyl ether (EGEE) is a colorless liquid with mild, agreeable odor. It is used as a solvent for nitrocellulose, lacquers and dopes; in varnish removers, cleansing solutions, dye baths; finishing leather with water pigments and dye solutions; increasing stability of emulsions. HUMAN EXPOSURE AND TOXICITY: Short-term exposure: The substance is mildly irritating to the eyes and respiratory tract, may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Long-term or repeated exposure: The liquid defats the skin, may have effects on the blood and bone marrow. The major long-term effects of exposure for humans are developmental, testicular, and hematological toxicity. A cross-sectional evaluation of semen quality was carried out in workers exposed to EGEE. A control group of workers from the same plant was included. Workers exposed to EGEE had significantly lower average sperm counts than controls, although both groups had lower sperm counts than those found in other occupational groups. In other study, hemoglobin, hematocrit, red cell indices, total and differe Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF value of 3 was calculated for ethylene glycol monoethyl ether(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.7X10-7 atm-cu m/mole(4). Ethylene glycol monoethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.31 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 4.7X10-7 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 74 and 540 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether, which has a vapor pressure of 5.31 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 hrs(SRC), calculated from its rate constant of 1.54X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Solvent; Not Known or Reasonably Ascertainable; Intermediate; Solids separation (precipitating) agent, not otherwise specified Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Laboratory chemicals; Intermediate; Solids separation (precipitating) agent, not otherwise specified; Not Known or Reasonably Ascertainable; Solvent Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Ethoxyethanol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as an industrial solvent and anti-icing additive to aviation fuels; [ACGIH] Used as a solvent for coatings, inks, adhesives, textile dyes, lacquers, and epoxy resins; [HSDB] Not produced commercially in the EU; [Glycol Ethers Online] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Solvent for nitrocellulose, lacquers and dopes; in varnish removers, cleansing solutions, dye baths; finishing leather with water pigments and dye solutions; increasing stability of emulsions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... Natural and synthetic resins; mutual solvent for formulation of soluble oils; lacquers and lacquer thinners, dyeing and printing textiles, varnish removers, ... anti-icing additive for aviation fuels. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chemical intermediate for 2-ethoxyethyl acetate, a solvent Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Solvent for epoxy and other coatings Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. This is an ideal property as a multi-purpose cleaner and therefore 2-ethoxyethanol is used in products such as varnish removers and degreasing solutions. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
New Zealand cosmetic product schedules 4–8
Source reference
Schedule 4, reference 666, source row 691
Source record ID
S4-691
Source version
effective-2026-01-01
Source language
English
Translation status
Original is English
Effective date
2026-01-01
Source updated
2024-01-01
Snapshot checked
2026-08-30 04:54 UTC
Validation method
openpyxl extraction; reviewed per-schedule counts
SHA-256
4e62e372fb0aad7ac630af8c41fa50b38b52a793fd51b99697a65f8ecce1ae8a

Registered dataset notes

Dataset coverage
Prohibited and restricted substances, permitted colorants, preservatives and UV filters
Authority note
Official EPA group standard schedules; current market-specific rule source
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2913
current New Zealand records
2166
records marked Prohibited
2913
records from this source version
2821
market records with CAS identity

Status distribution

Permitted list with conditions: 357Prohibited: 2166Restricted: 390

Condition text is present on 747 of 2913 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

New Zealand market context

Complete schedules dataset

Coverage version: Cosmetic Products Group Standard schedules effective 1 January 2026

Schedules 4–8: prohibited, restricted, colourant, preservative and UV-filter entries.

Verification checklist

  1. Search exact identity across Schedules 4–8.
  2. Apply use, concentration and warning conditions.
  3. Check hazardous-substance classification and Group Standard scope.
  4. Confirm the latest legal instrument, not only the spreadsheet.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “2-Ethoxyethanol [1]” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search exact identity across Schedules 4–8.
  3. Apply use, concentration and warning conditions.
  4. Check hazardous-substance classification and Group Standard scope.
  5. Confirm the latest legal instrument, not only the spreadsheet.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.

The record cites Schedule 4, reference 666, source row 691, source version effective-2026-01-01. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

2-Ethoxyethanol [1]. Schedule 4, reference 666, source row 691. New Zealand. Source version effective-2026-01-01. CosIng Checker regulatory record: https://cosingchecker.com/regulations/nz/records/7369/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for New Zealand

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: effective-2026-01-01
  • Effective date: 2026-01-01

What it does not prove

The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source