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RestrictedBinding ruleJPRegulator-hosted provisional English translationOfficial-source import checked

Chlorphenesin

Japan Standards for Cosmetics: Chlorphenesin

The provisional English translation of the MHLW Standards for Cosmetics lists this ingredient with the stated limit or use matrix.

All Japan recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
The provisional English translation of the MHLW Standards for Cosmetics lists this ingredient with the stated limit or use matrix.
Conditions and restrictions
Published three-column use matrix (rinse-off / leave-on / mucosal; blank means prohibited, ○ means no upper limit): 0.30 0.30

Substance identity

Official source name
Chlorphenesin
CAS
104-29-0
EC
203-192-6
Identity mapping
exact INCI name
Linked ingredient
CHLORPHENESIN
Search this identity across the siteCAS 104-29-0EC 203-192-6

Linked CosIng identity data

Names and aliases

CHLORPHENESINchlorophenesin

CosIng description: 1,2-Propanediol, 3-(4-chlorophenoxy)-

EU inventory restriction note: V/50

Recorded cosmetic function: ANTIMICROBIAL, PRESERVATIVE

Function pages:ANTIMICROBIAL, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 104-29-0
CAS 104-29-0PubChem CID 7697

Verified chemistry for CAS 104-29-0

Chlorphenesin

IUPAC name
3-(4-chlorophenoxy)propane-1,2-diol
Molecular formula
C9H11ClO3
Molecular weight
202.63 g/mol
Exact mass
202.0396719 Da
Monoisotopic mass
202.0396719 Da
XLogP3
1.2
Topological polar surface area
49.7 Ų
Molecular complexity
135.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

3-(4-Chlorophenoxy)-1,2-propanediolChlorphenesinumChlorphenesineClorfenesina1,2-Propanediol, 3-(4-chlorophenoxy)-3-(p-Chlorophenoxy)-1,2-propanediolGlycerol alpha-p-chlorophenyl etherp-Chlorophenyl-alpha-glyceryl ether
16 more reported names
3-(p-Chlorophenoxy)propane-1,2-diolI670DAL4SZCHEBI:3642RefChem:57031203-192-6ChlorophenesinGecophenDemykonp-Chlorophenyl glyceryl etherC9H11ClO3Clorfenesina [INN-Spanish]Chlorphenesine [INN-French]Chlorphenesinum [INN-Latin]NSC 6401Maybridge1_0001701,2-PROPANEDIOL, 3-(p-CHLOROPHENOXY)-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
1
3D hydrophobes
0
3D acceptor features
3
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1OCC(CO)O)Cl
InChI
InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2
InChIKey
MXOAEAUPQDYUQM-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3642

chlorphenesin

Glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.

Formula
C9H11ClO3
Average mass
202.637 g/mol
Monoisotopic mass
202.03967 Da
Formal charge
0
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
Additional curated names
3-(4-chlorophenoxy)propane-1,2-diol3-(4-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)propane-1,2-diolchlorphenesinChlorphenesinp-chlorophenyl-alpha-glyceryl etherglycerol alpha-p-chlorophenyl ether
Cross-references from this source
  • CAS: 104-29-0 — ChemIDplus
  • CAS: 104-29-0 — KEGG COMPOUND
  • REGISTRY_NUMBER: 2210845 — Reaxys
  • MANUAL_X_REF: C07928 — KEGG COMPOUND
  • MANUAL_X_REF: Chlorphenesin — Wikipedia
  • MANUAL_X_REF: DB00856 — DrugBank
  • MANUAL_X_REF: GB628497 — Patent
  • MANUAL_X_REF: US2468423 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-07-09. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7697

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (30.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (84.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (13.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (69.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (10.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (35.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 353 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Japan MHLW Standards for Cosmetics
Source reference
Appendix 3 section 2, entry 15
Source record ID
appendix-3-2:15
Source version
MHLW Notification No. 331 provisional translation, retrieved 2026-08-30
Source language
English provisional translation; Japanese text is canonical
Translation status
Regulator-hosted provisional English translation · English translation
Snapshot checked
2026-08-30 04:11 UTC
Validation method
pdftotext -layout plus strict per-table row counts
SHA-256
117fc949a82789ca66017163f19041cf2fcf6b5902708077c8e4f56c482dc8e2

Registered dataset notes

Dataset coverage
Prohibited and restricted ingredient appendices with concentration and use conditions
Authority note
Official MHLW standard; validate later Japanese updates before presenting current status
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

117
current Japan records
87
records marked Restricted
117
records from this source version
32
market records with CAS identity

Status distribution

Prohibited: 30Restricted: 87

Condition text is present on 117 of 117 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Japan market context

Complete Standards appendices dataset

Coverage version: MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot

Prohibited ingredients, restricted ingredients and permitted preservative/UV/colourant appendices present in the official standard source.

Verification checklist

  1. Search Japanese/English identity and CAS where present.
  2. Apply category and maximum-amount conditions.
  3. Check later MHLW notices against the Japanese source.
  4. Verify marketing licence, notification, labelling and quasi-drug classification.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Chlorphenesin” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search Japanese/English identity and CAS where present.
  3. Apply category and maximum-amount conditions.
  4. Check later MHLW notices against the Japanese source.
  5. Verify marketing licence, notification, labelling and quasi-drug classification.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.

The record cites Appendix 3 section 2, entry 15, source version MHLW Notification No. 331 provisional translation, retrieved 2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Chlorphenesin. Appendix 3 section 2, entry 15. Japan. Source version MHLW Notification No. 331 provisional translation, retrieved 2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/jp/records/665/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Japan

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: MHLW Notification No. 331 provisional translation, retrieved 2026-08-30

What it does not prove

The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source