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Permitted list with conditionsBinding ruleGBOriginal is EnglishOfficial-source import checked

Chlorphenesin

The consolidated GB Cosmetics Regulation lists this record in Annex V.

All Great Britain recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Permitted list with conditions
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex V.
Conditions and restrictions
0,3%

Substance identity

Official source name
Chlorphenesin
CAS
104-29-0
EC
203-192-6
Identity mapping
cas_number
Linked ingredient
CHLORPHENESIN
Search this identity across the siteCAS 104-29-0EC 203-192-6

Linked CosIng identity data

Names and aliases

CHLORPHENESINchlorophenesin

CosIng description: 1,2-Propanediol, 3-(4-chlorophenoxy)-

EU inventory restriction note: V/50

Recorded cosmetic function: ANTIMICROBIAL, PRESERVATIVE

Function pages:ANTIMICROBIAL, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Current record
Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 104-29-0
CAS 104-29-0PubChem CID 7697

Verified chemistry for CAS 104-29-0

Chlorphenesin

IUPAC name
3-(4-chlorophenoxy)propane-1,2-diol
Molecular formula
C9H11ClO3
Molecular weight
202.63 g/mol
Exact mass
202.0396719 Da
Monoisotopic mass
202.0396719 Da
XLogP3
1.2
Topological polar surface area
49.7 Ų
Molecular complexity
135.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

3-(4-Chlorophenoxy)-1,2-propanediolChlorphenesinumChlorphenesineClorfenesina1,2-Propanediol, 3-(4-chlorophenoxy)-3-(p-Chlorophenoxy)-1,2-propanediolGlycerol alpha-p-chlorophenyl etherp-Chlorophenyl-alpha-glyceryl ether
16 more reported names
3-(p-Chlorophenoxy)propane-1,2-diolI670DAL4SZCHEBI:3642RefChem:57031203-192-6ChlorophenesinGecophenDemykonp-Chlorophenyl glyceryl etherC9H11ClO3Clorfenesina [INN-Spanish]Chlorphenesine [INN-French]Chlorphenesinum [INN-Latin]NSC 6401Maybridge1_0001701,2-PROPANEDIOL, 3-(p-CHLOROPHENOXY)-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
1
3D hydrophobes
0
3D acceptor features
3
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
4.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1OCC(CO)O)Cl
InChI
InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2
InChIKey
MXOAEAUPQDYUQM-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3642

chlorphenesin

Glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.

Formula
C9H11ClO3
Average mass
202.637 g/mol
Monoisotopic mass
202.03967 Da
Formal charge
0
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
Additional curated names
3-(4-chlorophenoxy)propane-1,2-diol3-(4-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)propane-1,2-diolchlorphenesinChlorphenesinp-chlorophenyl-alpha-glyceryl etherglycerol alpha-p-chlorophenyl ether
Cross-references from this source
  • CAS: 104-29-0 — ChemIDplus
  • CAS: 104-29-0 — KEGG COMPOUND
  • REGISTRY_NUMBER: 2210845 — Reaxys
  • MANUAL_X_REF: C07928 — KEGG COMPOUND
  • MANUAL_X_REF: Chlorphenesin — Wikipedia
  • MANUAL_X_REF: DB00856 — DrugBank
  • MANUAL_X_REF: GB628497 — Patent
  • MANUAL_X_REF: US2468423 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-07-09. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7697

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (30.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (84.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (13.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (69.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (10.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (35.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 353 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex V, entry 50
Source record ID
V-50
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
245
records marked Permitted list with conditions
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Chlorphenesin” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This identity appears on a market positive list for the list function represented by the source record. Confirm that the intended function and product use fall within the list scope and every stated condition.

Positive-list presence is purpose-specific and is not blanket approval for every cosmetic use. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex V, entry 50, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Chlorphenesin. GB Cosmetics Regulation, Annex V, entry 50. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6642/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This identity appears on a market positive list for the list function represented by the source record.

Confirm that the intended function and product use fall within the list scope and every stated condition.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Permitted list with conditions
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source